Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Cerebral Vasculature"”.
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Comprehensive geometric modeling of human cerebral vasculature for quantitative vascular analysis
… and structured geometric model of human cerebral vasculature for quantitative anatomical analysis. We first proposed a general and structured geometric representation of the interconnected vascular network as a framework. We then described an image processing pipeline for the segmentation …
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Characterisation of a Novel GABA Signalling System in the Human Cerebral Vasculature
… in the rodent brain and in the human peripheral vasculature, but the receptor systems and cellular machinery underlying this regulation have not been characterised. And as yet, there have been no attempts to confirm the existence of this putative vascular GABA signalling system in the human …
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Role of Cerebral Vasculature and Effect of Circulating Exosomes in Propagation of Systemic Inflammatory Responses into the Central Nervous System
… signaling. Gene expression profiling on the cerebral vessels isolated from the brains of the mice treated with peripheral lipopolysaccharide (LPS) revealed that the cerebral vasculature responds within minutes to acute systemic inflammation by upregulating the expression of immediate early …
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The Baroreflex And Neurogenic Control Of Cerebral Autoregulation In Cerebral Blood Flow
Introduction The neurogenic component of cerebral autoregulation (CA) refers to those mechanisms controlling cerebral blood flow under the influence of the nervous system, and which rely on the innervation of the cerebral blood vessels. The neurogenic control of CA is incompletely understood. …
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A pseudo-Bayesian model-based approach for noninvasive intracranial pressure estimation
… A first-order subject-specific model of the cerebral vasculature relates arterial blood pressure with cerebral blood flow velocity. The model is solved for a range of physiologically plausible ICP values, and the resulting residual errors are transformed into likelihoods for each candidate …
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Exploring The Translational Clinical Value of Cerebrovascular Reactivity Assessments by Diffuse Correlation Spectroscopy
… reactivity (CVR), i.e., the ability of cerebral vasculature to dilate or constrict in response to vasoactive stimuli, is a biomarker of vascular health and CVR quantification is considered an unmet clinical need. However, the value of addressing this unmet need is not clear. This thesis …
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Fibrin Formation and Dissolution in the Progression of Amyloid-Beta Pathology in Alzheimer's Disease
… patients suffer from brain hypoperfusion, the cerebral vasculature is damaged, and abnormal hemostasis is present. Circulatory deficiencies could therefore play an important role in the pathogenesis of this disease. We found an increase in blood brain barrier (BBB) permeability and …
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Magnetic Soft Continuum Robots for Telerobotic Stroke Intervention
… access to hard-to-reach areas in the complex cerebral vasculature. Our system also allows an operator to work remotely from the radiation source to minimize x-ray exposure during the intervention. Furthermore, it may open the possibility of remote procedural services for telerobotic stroke …
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The Role of Age and Model Severity on Cortical Vascular Response Following Traumatic Brain Injury
… biochemical events, including disruption of the cerebral vasculature and breakdown of the blood brain barrier (BBB) that exacerbate secondary injuries. A better of understanding of the mechanism(s) underlying cerebral vascular regulation will aid in establishing more effective treatment …
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3D reconstruction of cerebral blood flow and vessel morphology from x-ray rotational angiography
… routinely used to determine the geometry of the cerebral vasculature. To this end, contrast agent is injected into one of the supplying arteries and the x-ray system rotates around the head of the patient while it acquires a sequence of x-ray images. Besides information on the 3D geometry, this …
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Effects of Elevated Intracranial Pressure on a Cerebral Vein Model
… remains challenging [2]. The effects of occluded cerebral venous flow on intracranial pressure (ICP) have not been considered in a model for HBI as opposed to the context of stroke and neonatal hypoxic-ischemic encephalopathy. In this project, the effects of elevated ICP on the hemodynamics and …
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SEX DIFFERENCES IN GENE EXPRESSION AND PAIN-RELATED BEHAVIORS IN A PRECLINICAL MODEL OF MIGRAINE
… those in the trigeminal ganglion that innervate cerebral vasculature. Previous work has shown that CGRP levels are increased in animal models of inflammatory pain and in the external jugular vein of humans during migraine attacks. The CGRP receptor is comprised of three proteins: a G-protein …
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Computational modelling of global haemodynamics and its interaction with cerebrospinal fluid and brain dynamics with application to essential hypertension
… and compliances; myogenic mechanism of cerebral blood regulation; baroreflex control of arterial pressure. Concerning the first medical topic, we couple the circulation to a refined description of the cerebrospinal fluid (CSF) dynamics in the craniospinal cavity. Two versions of the CSF …