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Showing 1 to 20 of 21 for “"Cerebral Small Vessel Disease"”.
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Genetics of Cerebral Small Vessel Disease
Cerebral small vessel disease (SVD) is a leading cause of stroke and vascular dementia. The majority of cases are sporadic, occurring in the elderly hypertensive population. However, there also exist patients with familial disease. The most common form is Cerebral Autosomal Dominant Arteriopathy …
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hiPSC-Derived Cerebral Small Vessel Disease Models
Cerebral small vessel disease (cSVD) is an umbrella term of disorders that affect the small perforating arteries of the brain and is a major cause of stroke and dementia worldwide, but its pathology is yet to be known. We hypothesise that the integrity of the blood brain barrier (BBB) is disrupted …
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On the origin of cerebral small vessel disease
Contains fulltext : 219047.pdf (Publisher’s version ) (Open Access)
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Sporadic cerebral small vessel disease and cognitive abilities
Cerebral small vessel disease (SVD) is a leading cause of vascular cognitive impairment, contributing to multiple neurological disorders ranging from stroke, to mild cognitive impairment and dementia. However, despite a huge number of studies on the subject, we have a limited understanding of how …
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Unravelling the Genetics of Cerebral Small Vessel Disease
Cerebral small vessel disease (CSVD) is a major cause of stroke and vascular dementia. While CSVD is mostly sporadic (caused by a complex mix of environmental and genetic risk factors), its rare monogenic forms have been increasingly identified. The most common of these, cerebral autosomal dominant …
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The role of cerebral small vessel disease in dementia
Introduction: Cerebral small vessel disease (SVD) is increasingly recognised as a key factor in dementia and cognitive impairment, although its role in the pathogenesis of Alzheimer’s disease (AD) remains poorly understood. Through the investigation of how SVD relates and interacts with (1) …
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Disease mechanisms and markers of progression in cerebral small vessel disease
Introduction <br>Cerebral small vessel disease (SVD) is a common disease process accounting for a quarter of all ischaemic strokes, around 80% of haemorrhagic strokes, and is the major contributor to vascular cognitive impairment and dementia. Despite it being a major public health burden, …
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Blood-Brain Barrier Permeability and Inflammation in Cerebral Small Vessel Disease
Introduction: Cerebral small vessel disease (SVD) is responsible for a third of strokes and is the most common cause of vascular dementia. It is characterised by white matter lesions and more diffuse damage outside of the lesions. Despite its importance, the mechanisms causing white matter damage …
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Mechanisms of vascular cognitive impairment in cerebral small vessel disease and stroke
Introduction: Cerebral small vessel disease (CSVD) affects small vessels in the brain and is a major contributor to stroke and vascular cognitive impairment (VCI). Although VCI poses a significant public health burden, the underlying biological processes and mechanisms remain poorly understood. The …
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On the neurobiology of apathy and depression in cerebral small vessel disease
Cerebral small vessel disease (SVD) is a cerebrovascular pathology that affects the small vessels of the brain, resulting in heterogeneous brain tissue changes. These can lead to neuropsychiatric symptoms such as apathy, a loss of motivation, and depression, which is characterised by low mood and a …
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Applications of Machine Learning to Neuroimage Analysis in Cerebral Small Vessel Disease
Introduction Cerebral small vessel disease (CSVD) causes around 25% of ischaemic strokes and contributes to nearly half of dementia cases worldwide. Neuroimaging, particularly magnetic resonance imaging (MRI), is fundamental to the assessment, prognosis, and pathophysiological study of CSVD. …
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Fatigue in Cerebral Small Vessel Disease and its Relationship to Cognitive Behavioural Symptoms
Introduction <br>Cerebral Small Vessel Disease (SVD) is a disease affecting the small blood vessels in the brain. SVD is a leading cause of both stroke and vascular dementia, whilst cognitive behavioural symptoms such as fatigue are also frequent. Fatigue has a major impact on quality of life, yet …
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Multi-modality imaging assessment of cerebral small vessel disease biomarkers after stroke due to spontaneous intracerebral haemorrhage
In most cases, spontaneous intracerebral haemorrhage (ICH) is thought to result from cerebral small vessel diseases (SVDs). Cerebral amyloid angiopathy (CAA) and arteriolosclerosis (non-CAA SVD) are the two main types of SVD associated with ICH. The risk of recurrent ICH and post-stroke dementia …
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Evaluating Magnetic Resonance Imaging and Serum Markers As Surrogate Endpoints for Clinical Trials in Cerebral Small Vessel Disease
Cerebral small vessel disease (SVD) causes a quarter of all strokes and is the most common pathology underlying vascular cognitive impairment and dementia. White matter hyperintensities, lacunar infarcts, cerebral microbleeds and brain atrophy are characteristic features on conventional magnetic …
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Automated Brain Mapping to Evaluate the Relationship between Neurodegeneration, Cerebral Small Vessel Disease and Structural Covariance Network Disruption in Alzheimer's Disease
… number of persons suffering from Alzheimerâ s disease (AD) is expected to double to over a million within a generation in Canada. The pathological underpinnings of AD remain unclear but are thought to target large-scale brain systems. It is posited that disease of the brainâ s small blood …
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Pericyte deficiencies in a foxf2 loss of function mutant
… are critical players in vascular development and disease but are not widely studied in the context of cerebral small vessel disease, a vascular condition related to stroke that progressively weakens brain microvessels. Foxf2, a pericyte-expressed gene, is involved in vascular stability and reduced …
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White matter hyperintensities and lower extremity physical function before and after an aerobic exercise intervention in healthy older adults
… and a representative measure of age-related cerebral small vessel disease, white matter hyperintensity (WMH) volume in the brain, before and after an aerobic exercise intervention in a sample of relatively young and healthy older adults. Analyses also examined the role of WMH volume, physical …
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Sleep, Perivascular Spaces, and Cognition in Alzheimer's Disease and Parkinson's Disease
… conditions, such as Alzheimer’s disease and Parkinson’s disease. Two factors that are likely related to and may contribute to these cognitive deficits are sleep changes and enlarged perivascular spaces, which are an indicator of cerebral small vessel disease. In addition to being …
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Establishment of a Novel Patient hiPSC-derived in vitro Blood-Brain Barrier Model of Collagen IV Small Vessel Disease
Cerebral small vessel disease (SVD) is a prevalent cause of stroke (25-30%) and dementia (45%). Despite its frequency, little is known about the cause and disease progression of SVD. Matrisome alteration leading to blood-brain barrier (BBB) dysfunction is thought to play a role. Sporadic cases are …
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Blood pressure variability and the characteristics and outcomes of patients with intracerebral haemorrhage
… modifiable risk factor for spontaneous intracerebral haemorrhage (ICH). International guidelines about the management of high BP for primary prevention of cardiovascular disease and secondary prevention after stroke refer to mean or 'usual' BP targets for office BP monitoring (long-term …
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