Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Cerebral Cavernous Malformations"”.
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Investigation of the Molecular Mechanism for Cerebral Cavernous Malformations
<p>Cerebral cavernous malformations (CCM) are vascular anomalies of the central nervous system comprised of grossly-dilated blood-filled capillaries. CCM leisons may occur sporadically or by inheritance of a mutation in one of three genes, <italic>CCM1</italic>, <italic>CCM2</italic>, or …
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KLF4 IS A KEY DETERMINANT IN THE DEVELOPMENT AND PROGRESSION OF CEREBRAL CAVERNOUS MALFORMATIONS
Cerebral cavernous malformations (CCMs) are capillary-venous malformations located in the central nervous system that often lead to neurological deficits and cerebral hemorrhage. Pharmacological treatment limiting disease progression is dearly needed, as available therapy is limited to surgical …
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Structure-function Analysis of the STRIPAK Complex
… of three proteins mutated in familial cases of cerebral cavernous malformations (CCMs), was also found to reside within the STRIPAK complex. My project focused on the structural and functional characterization of STRIPAK. I mapped direct interactions and interacting regions on these proteins and …
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STK25 and TAO Regulate Muscle-Specific Transcription and Muscle Function in the Parasitic Flatworm Schistosoma Mansoni
… (TAO), serine threonine kinase 25 (STK25), or cerebral cavernous malformations 3 (CCM3) by RNAi in these worms produces a rapid and consistent deterioration consisting of detachment from the culture dish, drastic length reduction, selective paralysis in the worm body, and a distinctive …