Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"Ceramides"”.
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Ceramides as Therapeutic Targets in Bronchopulmonary Dysplasia
… clear. Recent works suggest the up regulation of ceramides in the injured lung as a potentially key factor. Ceramides regulate tissue growth pathways, by increasing autophagy and apoptosis. Ceramides are increased in tracheal aspirates of preterm infants receiving MV. Moreover, attenuation of …
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The role of ceramides in cigarette smoke-induced alveolar cell death
… apoptosis is not known. We hypothesized that ceramides are induced by CS via specific enzymatic pathways that can be manipulated to reduce lung cell apoptosis. CS increased ceramides in the whole lung and in cultured primary structural lung cells. Exposure to CS activated within minutes the …
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Elucidating the Role of Two Inotropic Agents in Cardiac Hypertrophy: the Ceramides and Apelins
… progression of CVD. The inotropic agents, the ceramides and apelins, represent two potential druggable targets that influence cardiovascular function. In this dissertation, we examined the impact of silencing the ceramide synthases (CERS) responsible for the production of the putative …
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Lipid signalling dynamics of palmitate-induced endoplasmic reticulum stress in skeletal muscle
… signal. In this thesis, long-chain ceramides (40:1 and 42:1) were identified as signals transmitting the induction of ER stress between myotubes via exosome-mediated transport. Long-chain ceramide concentrations were increased in skeletal muscle and blood plasma from in vivo models …
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Role of Ceramidase in Regulating Hepatic Lipid Metabolism and Whole Body Insulin Sensitivity
… syndrome. Specifically, the accumulation of ceramides in liver was shown to be associated with both hepatic insulin resistance and NAFLD. We recently demonstrated that the adipose-derived secretory factor adiponectin promotes an increase in ceramide catabolism, which is dependent on …
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Cytosolic sphingolipids and lysosome reactivation in neurodegenerative diseases
… approach has found several proteins that bind ceramides and glycolipids. Chapter 4 sought to confirm the interactions between ceramides/glycolipids and their binding proteins using molecular modelling and gene expression analysis.
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Regulation of Galactosylceramide Biosynthesis
… sphingolipid metabolism occurs at the step where ceramides are glycosylated to glucosylceramide (GlcCer) versus galactosylceramide (GalCer), which are precursors of all mammalian glycosphingolipids. Relatively few studies have focused on this branchpoint because these monohexosylceramides are …
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Role of Ceramide Accumulation in the Ventromedial Hypothalamus in Driving Systemic Metabolic Impairments During Obesity
… lipotoxic lipids is ceramide, a sphingolipid. Ceramides have been demonstrated to blunt insulin sensitivity and contribute to numerous obesity-related impairments of tissue function, as seen in vascular endothelium, pancreatic islets, heart failure, and muscle, liver, and adipose insulin …
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Regulation and functional significance of ATP binding cassette transporters in human placenta
… to abrogate the apoptotic effects of TNF- and ceramides was studied in primary trophoblast and BeWo cells using pharmacological and molecular (siRNA) approaches. The results suggest that BCRP/ABCG2 contributes to the resistance of trophoblast cells to cytokine-induced (extrinsic) apoptosis, …
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Hepatic and Extra-hepatic Metabolism in NAFLD and the Role of Hepatocyte Oxygen Sensing
… as well as cardiac steatosis and accumulation of ceramides. Hepatic *Epas1* deletion did not protect against this, but was instead associated with cardiac dysfunction independent of diet, as well as accumulation of diacylglycerols, ceramides, and again, SM 41:1 and 42:2. Hepatic *Epas1* deletion …
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The role of sphingosine kinases in pulmonary fibrosis
… regulate the balance between the proapototic ceramides and prosurvival sphingosine 1-phosphate. Sphingosine kinase 1 has a profibrotic role whilst the role of sphingosine kinase 2 is not defined. The objective of this project was to establish the effect of a range of previously reported as …
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Is there an association between S1P signaling and the transcription factor Nrf2?
… or sphingosine kinase inhibitors or short-chain ceramides to affect Nrf2. Although the work presented here does not support a relationship between Nrf2 and S1P, a direct connection between these two factors cannot yet be discounted. Based on their roles in cancer development, clarification of the …
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PNPLA3 P.I148M VARIANT INCREASES LIPID DROPLETS NUMBER AND SIZE IN PATIENT-DERIVED LIVER ORGANOIDS
… in sphyngomyelins, lysophosphatidylcholines and ceramides in PNPLA3 M/M Hep-HLO, which was exacerbated by FAs administration. These lipid species are associated with cellular damage, inflammation, Insulin resistance, oxidative stress and MASH development. The opposite trend was observed for …
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iPLA2β, ALTERNATIVE SPLICING AND APOPTOSIS OF PANCREATIC ISLETS
<p>Ceramides are bioactive lipids that can promote splicing of apoptosis-related genes, including caspase 9 and BCL-x. A recent study demonstrated that expression of neutral sphingomyelinase (NSMase), an enzyme that hydrolyzes sphingomyelins to generate ceramide, is regulated by Group VIA …
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Molecular characterization of the lipidome by mass spectrometry
… molecular sphingolipid species including ceramides, glycosphingolipids and inositol-containing sphingolipids, and sterol lipids including cholesterol. The performance of the methodology was validated by comparing its dynamic quantification range to that of established methodology based on …
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Protein-lipid interactions in raft-exhibiting membranes probed by combined AFM and FCS
… research to mimic the effect of long-chain ceramides, we investigated the effect of chain-length on ceramide-induced membrane reorganization. We could show that only long-chain ceramides (C18 and C16) form highly ordered domains. Interestingly, FCS measurements indicated that the physical …
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Synthesis of Biologically Relevant Sphingolipid Analogues
… we aimed at the synthesis of a new class of homoceramides, named N-homoceramides, which contain an extra methylene-spacer between the N-acyl chain and C2 of the sphingoid backbone. To this aim, we evaluated the introduction of branching by use of a cyano group, both in a sugar approach as in …
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Characterization of ceramide synthases (Cers) in mammalian cells
… is primarily acylated to 1-deoxydihydroceramides. These are an underappreciated category of bioactive sphingoid bases and "ceramides" that might play important roles in cell regulation and disease. In summary, cells contain a wide variety of Cer subspecies that are determined by changes …
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Natural variation in the human plasma lipidome signature using mass spectrometry: relevance to healthy ageing
… highest heritability among triglycerides and ceramides (h2 up to 0.59). These results confirm and extend previous findings, suggestive of age and sex as important factors which influence the human lipidome, especially in the oldest old. The association of APOE2 with increased …
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Structure-Activity Studies of Glycosphingolipids as Antigens of Natural Killer T Cells
… system. Critical to the recognition of glycosylceramides by NKT cells are antigen presenting cells (APC), such as dendritic cells, which are responsible for binding, processing, and delivery of ligands to these lymphocytes. This event is mediated by CD1d, a major histocompatibility complex-like …
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