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Showing 1 to 5 of 5 for “"Ceramide synthase"”.
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Ceramidsynthese in Saccharomyces cerevisiae
… is not due to lacking phosphoinositolation of ceramide, since the catalytic activity of the corresponding enzyme was proven in vivo.(v) The synthesis block in lag1Ddgt1D cells leads to an accumulation of sphingoid bases. In this connection it was shown, that Lag1p and Dgt1p are essential for …
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ROLE OF HEPATIC APOLIPOPROTEIN M AND ATP-BINDING CASSETTE TRANSPORTER A1 (ABCA1) IN LIPID METABOLISM
… synthesis and S1P secretion. Inhibition of ceramide synthase significantly increased cellular but not media S1P in apoM Tg hepatocytes, suggesting that apoM is rate limiting for S1P secretion. Overexpression of apoM<super>Q22A</super>, a mutant form of apoM with a cleavable signal peptide, …
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Influence of the Vitamin D3 Analog EB 1089 on Senescence and Cell Death Pathways in the Response of Breast Tumor Cells to Ionizing Radiation
… 1089 does cause an increase in radiation-induced ceramide generation in the cell, while the ceramide synthase inhibitor, fumonisin B1, inhibits apoptosis and increases cell viability following treatment with EB 1089 plus radiation. Signaling pathways that promote ceramide generation and autophagic …
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Pathogenesis of Fumonisin Toxicosis in Swine
… the pathogenesis of disease. Fumonisins inhibit ceramide synthase in the sphingolipid biosynthetic pathway, but the subsequent elevation of tissue sphingoid bases is not always associated with disease. The goal of these studies was to elucidate the pathogenesis of fumonisin toxicoses in swine. To …
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Characterization of ceramide synthases (Cers) in mammalian cells
This thesis describes the characterization of ceramide (Cer) biosynthesis by mammalian cells. The possibility that Cer undergo developmental changes was explored using mouse embryonic stem cells versus embryoid bodies by analysis of the Cer subspecies by liquid chromatography, electrospray …