Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Centrosomin"”.
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Centrosomin Self-Assembly and Centrosomal Protein Recruitment
… nuclear envelope prior to entry into mitosis. Centrosomin (Cnn) is a major centrosomal protein that is important for nucleation and organization of bipolar spindle microtubules at mitosis. Cnn protein localizes to the pericentriolar matrix and from there other centrosomal proteins 'load' onto …
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Characterising the function of CDK5RAP2 in the vertebrate centrosome
… mean. Orthologues of CDK5RAP2 in the fruit fly (Centrosomin/Cnn) and in fission yeast (Mod20p) have been well characterised and are known to have important roles in maintaining centrosome structure and in regulating microtubule nucleation. CDK5RAP2 shares two evolutionarily conserved domains with …
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Role of the Rcd4:Ana3 sub-complex in Drosophila centriole duplication
… proteins has remained unknown. Reduction in Centrosomin dots 4 (Rcd4) and Anastral spindle 3 (Ana3) are two such poorly characterised centriolar proteins. Thus, the aim of my thesis was to investigate the molecular functions of these two proteins in Drosophila centriole biogenesis. My …
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Regulation of γ-Tubulin Ring Complex Recruitment in Drosophila
… isoforms of the γ-TuRC tethering protein Centrosomin (Cnn) represent a means of regulating γ-TuRC recruitment and activity in a tissue-specific manner, and that this mechanism may be conserved in humans. I demonstrate that the extended N-terminus of centrosomal isoforms of Cnn is …
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Regulation of γ-Tubulin Ring Complex Recruitment in Drosophila
… isoforms of the γ-TuRC tethering protein Centrosomin (Cnn) represent a means of regulating γ-TuRC recruitment and activity in a tissue-specific manner, and that this mechanism may be conserved in humans. I demonstrate that the extended N-terminus of centrosomal isoforms of Cnn is …