Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Central Nervous System Development"”.
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GENETIC CONTROL OF EYE AND CENTRAL NERVOUS SYSTEM DEVELOPMENT
… the role of these Pax genes in neural development, by generating an allelic series of knock-in models at the Pax6 locus. We showed that Pax6(5a) and Pax2 could not replace Pax6 for its auto-regulation in lens induction or for neural differentiation in retina. In brain development, …
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Serum Response Factor Regulates Multiple Aspects of Central Nervous System Development
… whether SRF participates in earlier aspects of central nervous system development such as neuronal projection establishment, cell-fate specifications, and neural stem cell homeostasis and survival. We report that SRF is critical for development of major axonal tracts in the forebrain. …
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Microfluidics for Low Input Epigenomic Analysis and Its Application to Brain Neuroscience
… cell identity during both disease and normal development. The inherent plasticity of the epigenome paves new avenues for developing diagnostic and therapeutic tools for human diseases. Microfluidic technology has improved the sensitivity and resolution of epigenomic analysis due to its …
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Mechanisms of Translational Control
… aid in defining the role of selenoproteins in central nervous system development and maintenance.
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Mechanism of Lmx1b-regulated Limb Dorsalization
… factor is necessary for limb, kidney, eye, and central nervous system development. Lmx1b knockout (KO) mice display; abnormal limb dorsalization with distal ventral-ventral limbs, nephropathy, ocular malformations, loss of dopaminergic/serotonergic neurons, and reduced cerebellum and tectum …
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The cellular and molecular investigation of Wnt/FZD signalling during spinal cord neurogenesis
Spinal cord development has been studied extensively and is a model for embryonic patterning and cell differentiation. These processes are governed by extracellular and intracellular signaling and require gene transcription. Wnt signaling has been shown to be involved in dorsal-ventral patterning …
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The role of Ena/VASP and associated proteins in regulation of neuronal morphology and filopodia architecture
During central nervous system development cortical neurons extend a primary axon and multiple collateral branches to connect to numerous synaptic targets. While many guidance cues and their receptors have well-characterized roles in cortical axon guidance, the pathways that link these signals to …
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Three Hundred Year Record of Part Per Trillion (PPT)-level Perchlorate Measured with Ion Chromatography with Tandem Mass Spectrometry (IC - MS/MS)
… intake needed by the thyroid gland for proper central nervous system development in infants and for regulating metabolism in adults. The perchlorate in the environment today likely comes from both natural and anthropogenic sources. To reduce the threat posed by environmental perchlorate, it is …
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Identification of pluripotent stem cells and characterization of glia in the planarian Schmidtea mediterranea
… Schmidtea mediterranea has emerged as a model system for the study of stem cell biology, tissue specification, and axis formation. Many aspects of the regenerative machinery have yet to be characterized. Although it is known that neoblasts, the population of all proliferative cells in the adult …
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EXPRESSION OF SUBSTANCE P IN BRAINSTEMS OF VICTIMS OF SUDDEN UNEXPLAINED PERINATAL DEATH
… of the SP during the first phases of human nervous system development; to evaluate whether there are altered manifestations of this neuromodulator in victims of sudden death; to verify the correlation with maternal cigarette smoking and to see the evolutionary aspects of SP gene (TAC1) …
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Fattori prognostici nel melanoma cutaneo e nel tumore mammario associati a caratteristiche molecolari simil-staminali
… (a neuronal stem cell/progenitor cell marker of central nervous system development), vimentin (which is ubiquitously expressed in mesenchymal cells), and the glucocorticoid receptor (GR, which is involved in the immune response, cell proliferation, and apoptosis) have been shown to interact in …
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Investigating the functional and evolutionary significance of Group B Sox genes in arthropods
Group B Sox genes play a critical developmental role in both vertebrates and insects. Within the model species Drosophila melanogaster, two SoxB genes, Dichaete and SoxNeuro, have been shown to act as ‘master regulators’ in the early development of the central nervous system. SoxB genes have only …
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New roles for Hox and Wnt in Cell Migration
Neuron migration is a critical process during central nervous system development. In the dissertation below I report new roles for established genes such as Wnt and Hox, and describe roles for several new genes in neuron migration. To study migrating neurons I use the model organism nematode worm …