Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Central Amygdala"”.
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Organisation of Glutamatergic Inputs to Central amygdala
… that makes its clinical management challenging. Central amygdala (CeA) is a key neural substrate that contributes in the control of the pain response and modulates the affective-motivational component of pain. It is known that PKCδ (+) neurons in latero-capsular region of CeA (CeLC) is a dominant …
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Neurotransmitter Modulation of Alcohol-Induced GABAergic Signaling in the Central Amygdala
… negative affective states during withdrawal. The central amygdala (CeA), a predominantly GABAergic structure that integrates stress and reward signals, plays a critical role in the emotional and motivational processes that sustain alcohol dependence. Although pharmacotherapies targeting …
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CELL TYPE-SPECIFIC EFFECTS OF OPIOID DEPENDENCE ON CENTRAL AMYGDALA NEURONS
… how the neural substrates for pain, such as the central nucleus of the amygdala (CeA), are impacted by opioid dependence. Growing evidence reveals that the CeA comprises multiple functional cell-types. While decades of research implicate the CeA in opioid withdrawal, the cell type-identity of the …
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Characterizing Effects of Sphingosine-1-Phosphate Receptor 1 Activation in Subtypes of Central Amygdala Neurons and Effects of Prenatal Methadone Exposure on Motor Cortex Neurons in Mice
… signaling affects neuronal excitability in the central amygdala (CeA), a supraspinal node of the descending pain pathway. The CeA is made up of a heterogenous population of neurons which form complex local and long-range circuits. The central lateral amygdala (CeL) consists of two major …
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The role of amygdala group I mGluRs in synaptic plasticity and conditioned place preference in rodents
… of cocaine-induced CPP. Furthermore, the amygdala is known to be involved in the learned associations between cocaine and the cocaine-taking environment; changes in these associations are reflected in an in vitro model of plasticity, long-term potentiation, in amygdala pathways. Chronic …
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Lateral Parabrachial Choline Acetyltransferase Neurons and the Decision to Eat
… synaptophysin, the highest output being the central amygdala. Calcium dynamics were measured at the amygdala using the genetically encoded calcium indicator GCaMP. The dynamics around the decision to consume food were seen to be different between fasted and sated satiety states. Activation of …
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The Addicted Phenotype: Protein Phosphorylation Status and Dopamine Receptor Responsiveness
… receptor subunit at serine 845 in striatal and amygdala subregions, and the NMDA NR1 receptor subunit at serine 897 in the CA1 subregion of hippocampus. Tolerance also developed to cAMP-independent GluR1S831 phosphorylation in the prefrontal cortex. In contrast, sensitization to cocaine-induced …
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Role of the IKKβ/NF-κB pathway in alcoholism
… cortex (PFC), nucleus accumbens (NAc), amygdala (AMY), and ventral tegmental area (VTA)]. Subsequently, the effects of inhibiting/knocking down IKKβ were investigated both systemically and centrally to determine the effects on voluntary ethanol drinking. It was observed that both …
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Structural and Molecular Correlates of Individual Differences in Anxiety Behavior and the Stress Response
… and executive function; the hippocampus, amygdala and medial prefrontal cortex (mPFC). In the following experiments, we measured basal anxiety levels and compared anxiety behavior before and after stress. Individuals were grouped based on basal anxiety profiles (either "Calm" or "Anxious") …
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Infusion of oxytocin into the basolateral amygdala facilitates, whereas infusion into the central nucleus impairs extinction of context conditioned fear responses in rats
Increasing oxytocin (OT) in the central amygdala (CeA) via infusion of a selective OT agonist (Viviani et al., 2011) or optogenetic stimulation of hypothalamic neurons (Knobloch et al., 2012) reduced conditioned freezing responses. In contrast, intracerebroventricular (i.c.v.) administration of OT …
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Identification of central circuitry components mediating anorexigenic properties of oxytocin
… the OTr present in the basolateral (BLA) and central amygdala (CNA), sites implicated in emotional/pleasure processing of food intake, is involved in appetite control by OT. I injected OT in the BLA or CNA and assessed intake of chow induced by energy deprivation and intake of sweet solutions …
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A neural and behavioural investigation of aberrant feeding in animal models of autism spectrum disorder
… with satiety and reward. Specifically in the central amygdala (CEA), dorsomedial hypothalamus (DMH), ventromedial hypothalamus (VMH) and the nucleus accumbens (Acb). Excessive consumption palatable sucrose sucrose was was ameliorated in mutants by intraperitoneal administration of oxytocin …