Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"Cellular studies"”.
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Cellular Studies of Gluconeogenesis in the Ruminant
Made available in DSpace on 2014-12-14T15:29:38Z (GMT). No. of bitstreams: 1 7524401.pdf: 3931235 bytes, checksum: 3cc3c11eb5c2e21d2ad71b9cbbbe6ecb (MD5) Previous issue date: 1975
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Quantitative biological studies at cellular and sub-cellular level
… tweezers for quantitative measurements at cellular and sub-cellular level. In the cellular studies, multiple membrane tethers were extracted simultaneously under constant force transduced to eukaryotic cells through magnetic beads attached to their membranes. The tethers were characterized …
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Controlled Intracellular delivery of molecules using Nanoparticle-mediated Photoporation
Intracellular drug delivery has been of interest in recent years after the development of drugs targeting intracellular components. Delivery of exogenous material into cytosol has a variety of applications including cellular studies, therapies and diagnostics. Nanoparticle-mediated photoporation is …
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Miniaturized Fluorescence Biosensor for Studying Neuronal Events
… to realize the incredible variability in the cellular content and the response to stimulation between cells and within a single cell. Conventional analysis techniques yield an average result to describe the content and function of cells. This approach often misses important information since …
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Design, synthesis, and characterization of porphyrin derivatives for biological applications
… characterization, conformational analysis and cellular studies of novel mono conjugated regioisomers of chlorin e<sub>6</sub> derivatives that are promising photosensitizers for photodynamic therapy. All three regioisomers were synthesized from pheophytin a, which was extracted from the alga …
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Calcitonin Gene-Related Peptide Promotes Peripheral and Central Trigeminal Sensitization
… of primary trigeminal sensory neurons. For my studies, I used adult male Sprague Dawley rats that were injected with CGRP alone or co-injected with inhibitors and determined changes in nocifensive behavior and inflammatory proteins. Intrathecal injection of CGRP increased nocifensive responses …
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Defining the genetic and molecular pathways underlying motor neuron degenerative diseases
… in this thesis entails clinical, genomic and cellular studies which advance scientific knowledge of the genetic and molecular processes important for motor neuron health and survival. Chapter three describes the discovery of biallelic variants in the phospholipid synthesis (Kennedy) pathway …
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Advanced applications of Raman spectroscopy and super-resolution imaging of biological and plant materials
… understanding of processes at the molecular and cellular level. Raman spectroscopy has many advantages as an analytical method to help fill this knowledge gap: it can differentiate chemical structures with high sensitivity, it is non-destructive, it requires minimal sample preparation compared to …
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The Formation and Characterisation of Protein Bigels
… elastic moduli of their parent gels. Preliminary cellular studies showed a positive growth response towards the bigels when compared with collagen scaffolds and untreated wells, which in combination with their biocompatibility, biodegradability and mechanical strength highlights the huge potential …
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Syntheseses [sic] and evaluation of porphyrin derivatives for applications in medicine and in material science
… boron delivery agents for BNCT (prelimary cellular studies using some of these compounds have been performed). In Chapter 3 a new efficient route to synthesize a series of novel carboranylporphyrins is successfully developed, using Suzuki couplings on either the β or meso positions of …
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SELECTIVE GLYCOMIMETIC LIGANDS OF C-TYPE LECTIN RECEPTORS
… The determination of their antiviral activity in cellular studies is currently ongoing in the group of Dr. Delgado (Hospital Universitario 12 de Octubre, Madrid).
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High Resolution Distributed Sensing Using Exposed-Core Fibres
… imaging, which brings insights towards in vivo cellular studies in the future.
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Defining the molecular basis for the β-catenin and CDC73 interaction
… to developmental or environmental cues. Previous studies reported that β-catenin binds to the central region of CDC73, a subunit of the Polymerase Associated Factor 1 complex (PAF). PAF associates with Pol II during transcription elongation to stimulate processive elongation and co-transcriptional …
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Structural and Dynamic Proximal Proteomic Analysis of TRPV2 Ion Channel Activation
… regulated pathway which mediates every vital cellular function through the propagation of localized calcium flux. Transient receptor potential vanilloid type 2 (TRPV2) ion channels are calcium-permeable, tetrameric ion channels with implications in several cellular processes such as immune …
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Biophysical and Therapeutic Approaches to Neurodegenerative Disease: Insights From Lysosomal and RNA-Binding Protein Systems
… diseases arise from progressive failures in the cellular systems that maintain protein and RNA homeostasis, yet how distinct molecular defects contribute to the disease pathogenesis is incompletely understood. This dissertation investigates two complementary arms of this network: lysosomal …
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Host-Pathogen Interactions at the Intestinal Epithelial Barrier
… the intestinal epithelial barrier and the intracellular apicomplexan Eimeria spp., both in vivo and in vitro. Initially, conventional in vivo studies using genetically modified animals were used to investigate the contribution of innate lymphoid cells (ILCs) to immune protection of the …
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Luminescent Quantum dots for Cellular Analysis
… associated with use of organic fluorophores in cellular studies. Quantum dots show high photostability, high emission quantum yield, narrow and symmetric emission peaks and size-dependent wavelength tunability. The objective of my PhD studies was to develop CdSe/ZnS quantum dot-based probes and …
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The Role of Cytochrome P450 2E1 in Hepatic Ischemia Reperfusion Injury and Reactive Oxygen Species Formation
… of reactive oxygen species (ROS). Recent studies suggest that P450 enzymes may contribute to ROS generation, which may occur through their uncoupling and/or release of heme and iron after their degradation. Among P450 enzymes, CYP2E1 is unique because it is considered a leaky enzyme, …
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Exploring the Effects of Adjuvant Selection on a Novel Polyvalent Staphylococcus aureus Vaccine
… S. aureus clearance, and consequently, further cellular studies were undertaken with a novel TLR2 agonist to identify the protective host response. The splenocyte supernatant of mice immunised with the polySSL-TLR2 combination had increased production of the cytokines IFN-γ, TNF, and IL-6 …
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