Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"Cellular signal transduction."”.
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URSOLIC ACID INHIBITED PROLIFERATION AND INVASION OF MDA-MB-231 HUMAN BREAST CANCER CELLS VIA REGULATING CELLULAR SIGNAL TRANSDUCTION PATHWAYS
… human breast cancer cells via regulating cellular signal transduction pathways. Specific objectives are designed as: a) to investigate anti-proliferation and anti-invasion effects of UA in MDA-MB-231 human breast cancer cells; b) To determine specific molecular targets of UA on cellular …
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NEW METHODS FOR DETECTING BIOMARKERS OF OXIDATIVE STRESS AND REDOX SIGNALING ON PROTEIN CYSTEINE RESIDUES
… or oxygen species), participate in a variety of cellular redox processes and have become well recognized as messengers in cellular signal transduction. One important mechanism by which cellular redox-based signaling occurs is reversible oxidation of cysteine residues in the presence of low …
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The dynamics of enzymatic switch cascades
… a highly conserved architecture utilised in cellular signal transduction. In treating the equations of motion, we replace the usual deterministic differential equation formalism with stochastic equations to accurately model the 'effective collisions' picture of the biochemical reactions that …
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Characterization of Gf a Drosophila trimeric G protein alpha subunit
… and interpretation of the multitude of extracellular stimuli to which they are exposed. Plasma membrane receptors play a key role in the transmission of such signals. G-protein coupled receptors (GPCRs) are the largest class of cell surface receptors that respond to an enormous diversity of …
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Computational modeling of the IL-4 pathway to understand principles of systemic redox regulation in cell signaling
… that ROS such as hydrogen peroxide can act as signaling molecules and are required for physiological functioning of a number of signaling pathways. Therefore, a mechanistic basis of ROS-mediated regulation of cell signaling must be established to enable rational design of antioxidant-based …
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Chemically Based Interrogation of Smoothened, a Proto-Oncogenic Component of the Hedgehog Signal Transduction Pathway
Aberrant activation of the Hedgehog (Hh) signal transduction pathway is crucial for the initiation and maintenance of many cancer types. Underlying this deviant signaling process in most cases of cancer is genetic mutations that give rise to misactivation of the seven transmembrane oncoprotein, …
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Design principles of mammalian signaling networks : emergent properties at modular and global scales
… chemistry to investigate several aspects of cellular signal transduction at both the modular and global levels. Design principles of biological networks and cell signaling processes pertinent to disease progression emerge from these studies. It is my hope that knowledge of these principles …
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Computational analysis of cell-cell communication in the tumor microenvironment
… approach to include inferences of single-cell signaling pathway and transcription factor activity. We then identified protein-protein interaction networks that connect extra-cellular receptor-ligand interactions to intra-cellular signal transduction pathways. Using this approach, we compared …
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PhoQ: Structural and Mechanistic Investigations into an Important Bacterial Sensor Kinase
… systems represent the dominant mechanism for cellular signal transduction in prokaryotes. One particular system, PhoQ, has been the focus of our interest because it is the switch that controls virulence in Salmonella and other pathogenic gram negative bacteria. Certain domains of PhoQ and …
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Computational Ligand-Based CNS Therapeutic Design: The Search for Novel-Scaffold Norepinephrine Transporter Inhibitors
… (MAT) proteins are responsible for regulating cellular signal transduction through control of neurotransmitter reuptake in the synapse, and are therefore relevant to diseases including addiction, psychosis, anxiety and depression. MATs, specifically the serotonin transporter (SERT or 5-HTT), …
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Protein phosphorylation regulation in Arabidopsis
… are fundamental mechanisms involved in many cell-signaling events. Coordinated actions of protein kinases and protein phosphatases help maintain the signaling through reversible protein phosphorylation and dephosphorylation. In Arabidopsis, both protein kinases and protein phosphatases exist as …
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Physiological and cellular characterization of a plant natriuretic peptide
… capacity to survive. Plants can use multiple signaling pathways and signals to mediate their response; for example, at least four different signal pathways have been identified for water-deficit stress (Shinozaki and Yamaguchi-Shinozaki, 1997; Xiong et al., 2002). Different forms of stress may …
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Analysis Of The Structure And Function Of A Timp-1/cd63 Complex And Its Relationship To An Mt1-Mmp/cd63 Complex
<p>The relationship of the extra-cellular matrix (ECM) and secreted proteins to intra-cellular functions has an important impact on disease progression. The tissue inhibitors of metalloproteinases (TIMPs), of which there are four, are known for their broad metalloprotease inhibitory abilities. …
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The quorum-sensing regulation of Vibrio fischeri : novel components of the autoinducer/LuxR regulatory circuit
In the marine bacterium Vibrio fischeri two intercellular homoserine-Iactone signal molecules (luxI-dependent 30C6-HSL and the ainS-dependent C8-HSL) and the transcriptional activator LuxR regulate the luminescence system in a cell-density dependent manner by a process termed quorum sensing. In …
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Common Signaling Elements in Response Pathways Activated by the Endothelial Survival Factors VEGF and Insulin
… a common occurrence in diabetes mellitus. At the cellular level, dysfunction of vascular endothelial cells is often associated with diabetic conditions. Multiple agents maintain the endothelium, including vascular endothelial growth factor (VEGF), an endothelial cell mitogen/survival factor, and …
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In silico systems analysis of biopathways
… pathway alignment; recommends a nomenclature of cellular signal transduction; and attempts to standardize the representation of biological pathways. Hybrid Petri net methodology is exploited to model metabolic networks. Kinetic modeling strategy and Petri net modeling algorithm are applied to …
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Development of microelectrode arrays for real-time monitoring of alkaline phosphatase release from cells in clinical analysis
… facilitating the yield of recordings, signal shape, and signal-to-noise ratio. For the purposes of the research, electrochemical impedance devices had 40 electrodes distributed in 8 wells that facilitated continuous visualization of cell adhesion, spreading, proliferation, and …
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Carbachol- and ACPD-Induced Phosphoinositide Responses in the Developing Rat Neocortex
Signal transduction via the phosphoinositide (PI) second messenger system has key roles in the development and plasticity of the neocortex. The present study localized PI responses to individual cortical layers in slices of developing rat somatosensory cortex. The acetylcholine agonist carbachol …
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Signal transduction events in human NK cells: role of PKC and calcium uptake in activated and inactivated NK cells
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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