Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Cellular shape"”.
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Dynamics and Structures of Phospholipid Assemblies
… hollow and polydisperse characteristics. (2) Shape transformation of lipid membrane. Seeking a general understanding of shape deformations associated with biological functions and cell proliferation, morphologies of giant lipid vesicles are studied to reveal their interactions with …
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Design of Biomembrane-Mimicking Substrates of Tunable Viscosity to Regulate Cellular Mechanoresponse
… impact cell adhesion, morphology and multiple cellular processes from migration to differentiation. While previous studies on polymeric gels have revealed the influence of substrate elasticity on cellular shape and function, a lack of suitable substrates (i.e. with mobile cell-substrate …
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The Function of Phosphatidylinositol 4-Kinase III-Beta in Trypanosoma Brucei
… in inhibition of cell growth and a distorted cellular morphology. Immunofluorescence studies revealed a distorted Golgi apparatus and mislocalization of lysosomal and flagellar pocket proteins. Ultrastructural analysis reveals internal accumulation of a heterogeneous population of vesicles, …
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Uniaxial Mechanical Assays on Adherent Living Single Cells : Animal Embryonic Fibroblasts and Human Pancreas Cancer Cells
… applied force, cell deformation and cellular shape are determined with highest accuracy. Uniaxial deformation is applied to a single cell which adheres between two parallel glass plates. Such mechanical assays accomplished at constant displacement or constant force allow for …
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Fluidization and Segregation in Confluent Models for Biological Tissues
… predict the non-linear behaviour responsible for cellular motion in tissues. Shifting from fluidization to segregation, I next focus on two-dimensional (2D) binary mixtures. I show that a difference in cellular shape or size is insuffcient to induce an emergent interfacial tension, and this leads …
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A study of the mechanism of action of novel inhibitors of tumour cell invasion
… It was found that both dhMotC and STP-26 affect cellular shape. dhMotC induced thick central actin stress fibres and large focal adhesions and caused cells to contract. STP-26 also induced adhesion formation but it reduced stress fibres and caused increased cell spreading. Both inhibitors …
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NMR AS A TOOL TO QUANTITATIVELY CHARACTERIZE MOLECULAR MECHANISMS GOVERNING ACTIN DYNAMICS AND RICE LATERAL ROOT DEVELOPMENT
… determined. This interaction is important for cellular shape, cell motility and stress fiber repair. This study presented a model for a mechanism of action where phosphorylation can act as a stoichiometric switch and can explain the importance of the phosphorylation cycle in the localization of …
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Influence of osmotic forces and transbilayer membrane area imbalances on the stability and morphology of model membrane vesicles
… including membrane fusion, maintenance of cellular shape and membrane trafficking. The osmotic stability of these large unilamellar vesicles (LUVs) in the present of plasma has also been investigated. This is of practical interest as these vesicles are currently being used as in vivo drug …
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Contrastive representation learning for bioimage quantification
… method for learning representations of cellular shape and texture from volume electron microscopy (EM) data. The method is applied to an EM volume of Platynereis dumerilii, and enables a visually consistent grouping of cells in the learned MorphoFeatures embedding space. Further, when …
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Function of Spectrin cytoskeleton in regulating epithelial architecture.
… a primary role for α-Spec in controlling cellular shape, perhaps by modulating actomyosin, and the proper localization of cellular junction. Thus, it is possible that proper cell-cell interactions, adequate force balance and precise spindle orientation are the keys in the maintenance of a …