Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 255 for “"Cellular response"”.
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The Molecular and Cellular Response to Pulmonary Contusion
… the mechanisms responsible for the inflammatory response to pulmonary contusion. This is due to several factors, including an inadequate characterization of the pathobiology at the molecular and cellular level, and a deficiency of valid small animal models in which to study this injury. In this …
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Understanding the Host Cellular Response to Astrovirus Infection
… of replication organelles and dysregulation of cellular processes. It is known that autophagy can play a key role in the viral lifecycle, from entry to egress, and can be either pro-virus or pro-host depending on the virus. RNA viruses often exploit autophagy machinery to create double membrane …
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A Common Cellular Response to Broad Splicing Perturbations
… are remarkably robust, and possess organized cellular response pathways to adapt to stress. Cellular stress responses to disruptions in many steps of the central dogma - from DNA synthesis to post-translational protein processing - are well classified. However, we have yet to establish a …
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Role of diacylglycerol in the cellular response to lysophosphatidylcholine analogues
… and investigated alteration in distribution in response to conditions where DAG levels were known to be altered. Two main pools were monitored over time using DAG sensors. One stable pool was associated with vacuolar membranes and a second temporal pool was localized to sites of polarized …
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Growth-factor-induced mitogenesis: Trafficking determinants of the cellular response
… and its receptor. However, the dynamics of the cellular trafficking of growth factors and their receptors can be an important determinant of the cellular response to growth factor stimulation. We have explored this hypothesis using the epidermal growth factor (EGF) receptor regulation of …
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Anc1 : a new player in the cellular response to DNA damage
… a role for ANC1 in the global transcriptional response to MMS treatment: expression changes in transcripts regulated in response to environmental stress are significantly abrogated in ANC1 cells.
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Characterizing the Cellular Response to Astrovirus Infection in the Central Nervous System
… neurological diseases. This study explores the cellular and molecular mechanisms by which AstV, specifically non-classical VA1 and classical HAstV1 genotypes, induce CNS pathology in human neurons and astrocytes. Utilizing primary human neurons and astrocytes from various brain regions, this …
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The Role of Prolactin in the Cellular Response to DNA Damaging Agents
… between the prolactin pathway and the DNA damage response is important in the mechanism. We previously identified that one isoform of heat shock protein-90 (HSP90), Hsp90alpha, is a prolactin-Janus kinase-2 (Jak2)-signal transducer and activator of transcription-5 (Stat5) regulated gene in breast …
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Computational analysis of cis-regulatory mechanisms underlying cellular response to drug perturbations
… factors such as SNPs and genes inform the response to medical interventions designed to ameliorate disease states, processes, and phenotypes; ontologically, it resides at the intersection of genomics and pharmacology. Regulatory genomics, however, directs its attention fully to the …
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Novel Roles of Replication Protein A Phosphorylation in Cellular Response to DNA Damage
… project presents 2 novel roles of RPA in the cellular response to DNA damage. The first elucidates the regulation of RPA and p53 interaction by DNA-dependent protein kinase (DNA-PK), ataxia telangiectasia mutated (ATM) and ATM- and Rad3-related (ATR) in homologous recombination (HR). HR and …
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The role of the chromatin remodeller ISWI in the cellular response to hypoxia
… Factor (HIF) is a master regulator of the cellular response to hypoxia. Its levels and activity are controlled by dioxygenases called Prolyl-Hydroxylases and Factor Inhibiting HIF (FIH). In order to activate genes, HIF has to access sequences in DNA that are integrated in chromatin. It is …
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Mechanical and Cellular Response to Biomineralization of Ovalbumin Scaffolds for Bone Tissue Engineering
… the OVA scaffolds without compromising in vitro cellular performance, Ca-P crystals were grown on unmodified OVA and phosphonated OVA (p-OVA) samples via biomineralization processes using 5x-concentrated simulated body fluid (5x SBF). Electron microscopy (ESEM/EDS) data confirm the formation of …
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Stab Wounds to Rat Brains : Demyelination, Remyelination and the Cellular Response, Particularly of Oligodendrocytes
<p>The present body of knowledge concerning the results of central nervous system injury is incomplete and controversial. The role of oligodendrocytes, the cells involved in phagocytosis, the stages of demyelination, and the evidence for remyelination are of interest. Following stab wounds to rat …
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The effects of the modification of energy metabolism on cellular response to ionizing radiation
… associated with energy metabolism on radiation response. It was proposed that ATP levels might be raised after irradiation in some systems and that this rise in ATP might be due to compensatory mechanisms related to repair. Experiments were conducted using B16 melanoma cells in vitro and using …
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Cisplatin-induced nucleosome and RNA polymerase II modification mediate cellular response to the drug
(cont.) with recombinant material. The in vitro system established in this study will facilitate the investigation of platinum-DNA damage by DNA repair processes and help elucidate the role of specific post-translational modification in NER of platinum-DNA adducts at the physiologically relevant …
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Analysis of trafficking dynamics and cellular response in the interleukin-2 ligand/receptor system
… cell-based immunity. The effects of IL-2 on its cellular targets are mediated solely through interaction with one or more forms of the IL-2 receptor (IL- 2R). The overall goal of this thesis is to quantitatively characterize IL-2/IL-2R interactions toward the scientific end of advancing the …
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P53-dependent apoptosis modulates the cellular response to oncogenes and the cytotoxicity of anticancer agents
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1994.
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Development of a Toolkit to Investigate Endocardial Endothelial Cellular Response in Left Ventricular Outflow Tract Pathologies
… membrane below the aortic valve. The underlying cellular mechanisms of this disease are currently unknown. I have created a toolkit to investigate the contributing factors of DSS membrane formation by isolating and characterizing endocardial endothelial cells (EECs) that line the left ventricular …
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