Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 21 for “"Cellular organization"”.
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On the theory of Brownian aggregation in colloidal dispersions
… also important in biological systems and affect cellular organization, enzyme catalysis, protein aggregation, and macromolecular binding. The primary focus of the thesis is on the fundamental study of this problem.
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The Effects of Toluene on the Ontogenetic Development of the Fish, Oryzias latipes, the Japanese Medaka
… deformities was influenced by: (1) the degree of cellular organization at the time the embryo was initially introduced to the toluene, and (2) the concentration of toluene to which the embryo was treated. Deformities were restricted to those embryos treated with toluene before stage 28 (74 hrs). …
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Molecular targets of chromatin marks H3K4ME3, H3K9ME3 and H3K27ME3 in an adult germinal niche
… in a delicate balance between maintaining cellular identity through self-renewal and differentiating into myriad neural cell types. Understanding exactly how epigenetic mechanisms regulate this balance and the subsequent differentiation process in adult mammalian brain is an ongoing effort. …
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Predicting Genetic Interactions Using Functional Interaction Networks
… genetic interactions is central to understanding cellular systems and identifying therapeutic vulnerabilities, particularly in the context of cancer. Among these interactions, synthetic lethality, where simultaneous loss of two genes is lethal but loss of either alone is tolerated, offers a …
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Transcriptomic and proteomic analysis of lycopene-overproducing Escherichia coli strains
… biological information from various levels of cellular organization. Such an approach is illustrated from a library of both rationally-directed and combinatorial gene knockout strains of E. coli recombinantly producing the small molecule lycopene. Global genomic and proteomic expression changes …
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MRI for gray matter: statistical modelling for in-vivo application and histological validation of dMRI
… the contribution of underlying cytoarchitecture (cellular organization) to dMRI measures in gray matter provides validation of dMRI measures of average and regional heterogeneity in MSD & Trace as markers of cytoarchitecture as measured by regional average and heterogeneity in cell area density. …
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Integration of Spatial Transcriptomics with Chromatin Images Using Graph-Based Autoencoder Identifies Joint Biomarkers for Alzheimer’s Disease
Tissue development and disease lead to changes in cellular organization, nuclear morphology, as well as gene expression. Spatial transcriptomic technologies, such as STARmap and 10x Visium, allow the joint measurement of these different modalities in whole tissue sections.1,2 However, methods for …
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Insights from biomolecular condensates into disease and drug development
… biology, ranging from a better understanding of cellular organization, to the exploration of novel mesoscale functions resulting from the emergent properties of these liquid-like compartments. A consideration of the role of condensates in disease and drug development could facilitate similar …
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Advanced in Vitro Models for Studying Bone Physiology
… structure. The presence of complex multi-cellular organization within opaque mineralized matrix makes it challenging to use conventional methods to study in vivo bone physiology even using model animals. To address this challenge, numerous in vitro models have been developed to study bone …
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Calcitonin Gene-Related Peptide Promotes Wound Healing of Cornea
… normal, healthy corneal tissue with respect to cellular organization, granulation tissue, and overall size of corneal epithelium when compared to saline treated wounds. Results from my study suggest that topical CGRP administration to a corneal wound promotes wound closure and morphological …
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The Role of Biomechanics in Liver Tissue Engineering
… tissue engineering is to use the process of decellularization to create acellular liver scaffolds that retain the native tissue's extracellular matrix and architecture. These scaffolds can then be repopulated with a variety of hepatic and non-hepatic cell-types depending on the application, or …
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Evolutionary and Developmental Survey of Genes Involved in Chordate Pigmentation
… to understand the establishment of eukaryotic cellular organization and for its implication in many human pathologies. For the first time, I reconstructed the evolutionary scenario of Rab family in eleven species of metazoans, spanning from cnidarians to human. Phylogeny, intron code and …
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Biomolecular Condensates Through a Computational Microscope Design, Mechanisms and Implications
… ubiquitous in biology, are crucial in organizing cellular functions and regulating various biochemical processes. In this thesis, I explore the emergent behaviours of these biomolecular systems via computational simulations and biophysical insights. I quantify and describe the key role of …
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Engineering Liver and Cardiac Models for Drug Development and Regenerative Medicine
… there are material challenges associated with cellular organization, tissue integration, vascularization, and structural properties. Liver tissue engineering approaches often do not integrate hepatic and biliary components, leading to incomplete understanding of fundamental cell-cell …
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Biocompatibility Investigations of Surgical Implant Alloys.
… responses (inhibited growth rates and altered cellular morphologies) at concentrations as low as 3.0 ppm (representing in ppm 2.0 Fe, 0.6 Cr, and 0.42 Ni). Cell cultures exposed to Co-Cr-Mo solutions demonstrated toxic responses at 1.5 ppm (representing in ppm 1.0 Co, 0.45 Cr, and 0.09 Mo). …
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Identifying genes related to symbiotic nitrogen fixation in Medicago truncatula Tnt1 insertion mutants using a forward genetics approach
… or Fix-. The Fix- mutant nodules displayed some cellular organization but distinct developmental zones could not be identified. Infection threads were observed in Fix- nodules that appeared to contain bacteria that had not been released; however, further microscopy analysis must be conducted to …
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Characterisation of a conserved motif found within the Dlx cis-regulatory element URE2 and its effect on mouse URE2-lacZ activity in transgenic mice
… to the genetic program involved in the cellular organization of the developing forebrain in vertebrates.
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OrganixInsights: High throughput imaging and high content screening of organoids
… to study complex biological systems at cellular and subcellular resolution. In particular, three-dimensional (3D) organoid models have emerged as powerful experimental systems for investigating tissue development, disease progression, and therapeutic response. Organoids replicate key …
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Exploiting network-based approaches for understanding gene regulation and function
… rather work in the context of other proteins and cellular entities during their life time. This has lead to the notion that cellular components can be visualized as wiring diagrams composed of different molecules like proteins, DNA, RNA and metabolites. These systems-approaches for quantitatively …
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Propagation of engineered cellular properties to colony scales in bacterial populations
… in nature. This process is an example of self-organization, whereby a global pattern of cells is generated by the propagation of local intercellular interactions to larger scales. Understanding this process is one of the fundamental challenges in biology and presents an opportunity to engineer …
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