Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 99 for “"Cellular membranes"”.
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Secondary ion mass spectrometry as a tool to evaluate chemical composition within model and cellular membranes
… of lipid components within the eukaryotic cellular membrane is critical to understanding their role in many cell processes. Secondary ion mass spectrometry (SIMS) is a technique that offers both chemical and spatial specificity, and has become popularized over the last decade for analyzing …
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Physiological Changes Occurring in the Cellular Membranes of Clostridium Acetobutylicum ATCC 824 and a Butanol-Tolerant Mutant During the Acetone-Butanol-Ethanol Fermentation
The acetone-butanol-ethanol fermentation by Clostridium acetobutylicum is not able to compete economically with the petroleum methods, due to the premature termination of this fermentation from the butanol produced by the cell. It is known that alcohols disrupt the membrane structure and function, …
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HIV entry : a biophysical and mutational analysis of gp41-mediated membrane fusion and its inhibition
… changes to mediate fusion of viral and cellular membranes. First, a short hydrophobic stretch of residues at the gp4 1 N-terminus insert into the target membrane, anchoring the protein in both viral and cellular membranes. This 'prehairpin' intermediate structure exposes an N-terminal …
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An obligate intracellular bacterial pathogen forms extensive and stable interkingdom contacts with the endoplasmic reticulum
Intracellular pathogens employ various mechanisms to manipulate host membranes, a critical strategy for subverting host pathways and advancing their life cycle. To this end, Rickettsia parkeri directly engages the host plasma membrane to infiltrate target cells and spread to neighboring ones. …
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Regulation and Functionality of Stress-Induced Cytochrome P450 Monooxygenases: A Functional Genomics Approach
… proteins directly from partially fractionated cellular membranes into soluble nanostructures that contain a native-like membrane environment. The resulting system is conducible to many of the biochemical methodologies previously restricted to soluble proteins and adds another tool to aid in the …
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Effect of Lipid Modification on Transformation - Associated Properties and Viral Membrane Assembly
… phospholipid and fatty acid composition of the cellular membranes in chicken embryo fibroblasts. We have used this technique to study the effect of lipid modification on various parameters associated with transformation in tissue culture. Lipid supplementation had a variety of effects on …
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BIOCHEMICAL CHARACTERIZATION OF ETHANOL MODIFIED PHOSPHOLIPIDS IN SACCHAROMYCES CEREVISIAE
… (PETH) IS REGARDED AS AN ABNORMAL LIPID IN CELLULAR MEMBRANE, UNIQUELY FORMED FROM PHOSPHATIDYLCHOLINE VIA PHOSPHOLIPASE D-CATALYZED TRANSPHOSPHATIDYLATION IN THE PRESENCE OF ETHANOL. IT HAS A DISTINCTLY DIFFERENT CHEMICAL STRUCTURE COMPARED WITH OTHER PHOSPHOLIPIDS AND MAY PERTURB THE …
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A comparative look at structure-function roles in light-harvesting dynamics of purple bacteria
… are able to carry out this efficient transfer in cellular membranes despite the complex environment found in these membranes. Particularly, light-harvesting in photosynthetic purple bacteria uses a diverse set of tools from species to species to efficiently transfer energy through this protein …
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Interaction of amphiphilic gold nanoparticles with lipid membranes and their application to cancer radiotherapy
… and potent evolution of gold nanoparticle intracellular delivery vectors. Here we propose the combination of striped gold nanoparticles with lipid vesicles of diameter < 200 nm in order to concentrate their delivery and couple their delivery to the delivery of pharmaceuticals. Mechanisms of …
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Conformational Dynamics of the Glutamate Receptors via single Molecule Förster Resonance Energy Transfer
… system, mediating synaptic transmission through cellular membranes. These proteins have developed a quick response to agonist presence and, when activated, undergo a conformational shift that allows calcium ion transport across the membrane. In a number of neurological diseases, genetic variants …
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Examining the effect of anti-tumor lipid drugs on pH homeostasis and membrane structure in Saccharomyces cerevisiae
… anti-tumor lipid drug that is known to target cellular membranes. The underlying mechanisms leading to cell death remain largely controversial, although previous results obtained using yeast, have indicated that edelfosine associates with lipid rafts at the plasma membrane (PM), resulting in …
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Vps1, a Novel Recycling Factor For the Traffic of Early Endosome to Late Golgi
Recycling of cellular membranes and their constituents plays a role for cell survival and growth. In the budding yeast, there are recycling traffics from early and late endosomal compartments to the late Golgi. Here, I examined a possible role for Vps1, a large GTPase, in the recycling traffic of …
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Adaptive immune responses in atherosclerosis - or how to prolong the use of your yellow socks
… cholesterol, which is an essential component of cellular membranes, and inflammatory cells at the injury site. Since cholesterol particles are not normally accumulating extra-cellularly, they are affected by the inflammatory environment, which modifies the particle structure. Since this can be …
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Influence of protein and lipid domains on the structure, fluidity and phase behavior of lipid bilayer membranes
… environment. Protein and lipid domains in cell membranes can facilitate receptor localization, stabilize membranes, and influence membrane fluidity. In this thesis, we study how ordered protein and lipid domains influence the physical properties of lipid bilayers to better understand the roles …
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Conformational ensembles and dynamics of amphipathic aggregates and proteins examined by synergy of NMR experiments and MD simulation
… systems, such as disordered proteins, cellular membranes and other amphiphilic aggregates, are beyond the scope of these methodologies. This thesis demonstrates how these disordered biomolecular systems can be characterized using a combination of Nuclear Magnetic Resonance (NMR) and …
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Migration of Nucleocapsids in Vesicular Stomatitis Virus-Infected Cells is Dependent on Microtubules and Actin Filaments
… to their affinities to the cytoskeleton and cellular membranes. This cargo is carried along the cytoskeleton and membranes using a variety of cytoskeletal motors and adapter proteins. Viruses hijack these pathways to distribute their proteins and genetic material. Vesicular stomatitis virus …
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Atomic-level characterization of protein-lipid interactions using molecular dynamics simulations
… proteins that are involved in fundamental cellular processes. Their activity of these proteins is frequently modulated through their interaction with cellular membranes, and as a result techniques to study the interfacial interaction between peripheral proteins and the membrane are in high …
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Development of methodology for the use of multi-bed sorbent traps with gas chromatography time of flight mass spectrometry
… lipid peroxidation of unsaturated fatty acids in cellular membranes leads to the formation of alkanes, aldehydes, alkanals, alk-2-enals, and hydroxyl alkenals. The free radicals formed during the process of lipid peroxidation can react with and damage cellular components. Lipid peroxidation is …
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Ion current modulation in bio-mimetic channel systems
… facilitating electrical signals across and along cellular membranes. Applying the same principles to man-made systems requires synthetic ion channels that can alter their conductance in response to various external manipulations. And the modulation of ionic current is a signal for nanopore …
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Folding, dynamics and interaction studies of the Neuropeptide Y family.
… such as folding and the interaction with cellular membranes may greatly advance the treatment of human disease. The Neuropeptide Y family of peptides are highly conserved peptides found in nature, consist of 36 amino acids, and are widely distributed in the central nervous system of …
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