Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 74 for “"Cellular interactions"”.
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Cellular interactions with hydrogels
… new chemical techniques that may predict cellular behaviour. The keratoprosthesis is a typical example of the need to be able to manipulate cell adhesion of materials since both adhesive and non adhesive sections are needed for proper integration and optical function. Calcein AM/ethidium …
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Cellular Interactions During Motor Nerve Regeneration
… with their original synaptic targets. The interactions between injured nerves with cells in their environment, as well as the functional significance of these interactions, have not been determined in vivo and in real time. Here we provide the first minute-by-minute account of cellular …
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Cellular interactions of the cytolethal distending toxins
… existing pathways as a mean to access intracellular targets and modulate host cellular functions. Among known targets in the human host, nucleus has been an infrequent, covert, and a coveted target, and very few external factors have been known to reach nucleus. Cytolethal Distending Toxin …
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Oncogene-induced reprogramming of heterotypic cellular interactions
… signalling hub that orchestrates fundamental cellular decisions such as cell survival, proliferation and differentiation. Activating mutations in KRAS are among the most frequently occurring oncogenic mutations driving cancers that are particularly refractory to therapy (e.g., colorectal, …
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Recording Cellular Interactions in Germinal Centers and Beyond
<p>In multicellular organisms, each cell has a distinct identity characterized by unique transcriptional and chromatin accessibility profiles. However, to truly understand the organization and function of such systems, it is not enough to merely characterize individual components; we must also …
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Evaluation of cellular interactions with functionalized scaffolds for cardiovascular tissue engineering
Introduction: Cardiovascular disease is a leading cause of death worldwide, with heart valve disease in particular becoming a rising problem in developing countries. Tissue engineering offers the next step in heart valve tissue replacement surgery. Synthetic scaffolds used in tissue engineering …
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Examining Cellular Interactions and Response to Chemotherapy in The Glioblastoma Perivascular Niche
… features were significantly reduced and EC cellular proliferation decreased up to 69% with Avastin® treatment. Significant increases in percentages of colocalized and GFAP+/vWF+ cells were also observed when treated with 8 µg/mL Avastin®. This suggests that chemotactic signaling may have …
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Fabrication, Characterization and Cellular Interactions of Keratin Nanomaterial Coatings for Implantable Percutaneous Prosthetics
… acid motif is the primary site responsible for cellular attachment. In the present work, keratins extracted from human hair fibers and recombinant keratin nanomaterials (KN) were used to create biomimetic coatings on silanized Ti surfaces. These coatings were characterized and investigated for …
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Lineage specification of ovarian theca cells requires multi-cellular interactions via oocyte and granulosa cells
… origins of theca cells and reveal a novel multicellular interaction via GDF9 and Hedgehog signaling critical for ovarian folliculogenesis and formation of a functional theca.
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Novel approaches to assess cellular interactions and their role in the pathology and treatment of lymphoproliferative disorders
… tissues, where they engage in the complex cellular and molecular interactions that underlie their survival, proliferation, and drug resistance. Further emphasising this importance, has been the observation that highly effective small molecule inhibitors that target key components of the BCR …
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Understanding adipokine secretion and adipocyte-macrophage cellular interactions, in search for the molecular basis of insulin sensitivity and resistance
… and adiponectin secretion involve distinct intracellular compartments and pathways. Insulin resistance is associated with macrophage infiltration into adipose tissue and elevated levels of IL-6, TNF-alpha and IL-1beta Therefore, the second part of my dissertation tested the hypothesis that the …
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Destabilization of IL-8 mRNA by Anthrax Lethal Toxin: Demonstration of the Requirement for TTP and Examination of its Cellular Interactions
… to AU-binding proteins (AUBPs) that can recruit cellular decay enzymes. The stability of ARE-containing mRNAs can be regulated by extracellular stimuli, which allows for cells to adapt to the changing environment. AREs are found in many transcripts that encode for inflammatory genes, including …
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Co-Culture of Amphibian Adrenal Cells: A Model of Medullary Control of Corticosteroidogenesis
Chromaffin-adrenocortical cellular interactions have become recognized as an important component of adrenocortical regulation, however, the mechanisms by which chromaffin cells modulate adrenocortical function are not well understood. To study chromaffin-adrenocortical cellular interactions …
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A single-cell perspective on infection
… is ultimately determined by a series of cellular interactions between invading pathogens and host immune cells. It has long been understood that these interactions, even when they occur in tissue culture models, give rise to a wide variety of different outcomes, some beneficial to the …
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THE INFLUENCE OF THE MICROENVIRONMENT OF HEALTHY AND TUMORAL CELLS
Cells use the extracellular matrix (ECM), a part of their microenvironment, as a scaffold for their anchorage, and interact with it in a reciprocal way. The ECM is mainly composed of a three-dimensional network of collagen and crosslinked proteins, such as fibronectin and laminin; ECMs from various …
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Developing a biomaterial model of the glioblastoma perivascular niche to investigate the effects of angiocrine signals on disease progression
… platforms that recapitulate the architecture and cellular interactions found in the in-vivo PVN are lacking and limit the exploration and discovery of angiocrine cues. Thus, this dissertation focuses on the development of biomaterial platforms to recapitulate the tumor-vascular cellular …
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Combinatorial Polymer Synthesis and High-Throughput Screening Technology to Identify Optimal Approaches for Mineralized Tissue Engineering
… all affected the degradation, mechanics, and cellular interactions of the materials. Using set design criteria with respect to degradation and cellular interactions, the library was screened to identify an osteoconductive material for use in bone tissue engineering. The identified macromer, …
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Using heterogeneous Graph Neural Networks(hGNN) to predict cell-cell communication
… diverse computational methodologies for modeling cellular interactions using single-cell RNA sequencing (scRNA-seq) data. We evaluate the performance of Graph Neural Networks (GNNs) both with and without gene-gene edges, Contrastive Learning, and Variational Autoencoders (VAEs) across multiple …
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