Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"Cellular immune response"”.
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Cellular Immune Response And Gene Expression Profiling In Crohn's Dise
… the presence of map dna, the state of the cellular immune response and microarray gene expression profiling in peripheral blood and surgical tissue from cd, uc and healthy control subjects. Nested pcr detected map dna in tissue from 10/12(83%) cd patients compared to 1/6(17%) non-ibd …
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Modeling the Effects of Drugs of Abuse on HIV Infections with Two Viral Species
… viruses that can escape recognition of the hosts immune response. Experimental results have shown that the presence of morphine can decrease the viral mutation rate and cellular immune responses. This thesis presents a mathematical model to determine if the decrease in mutation and cellular immune …
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Age and Dose Dependent Susceptibility to Mycobacterium avium subspecies paratuberculosis Infection in Dairy Calves
… in dairy calves. Additionally, the course of immune responses as well as fecal shedding was assessed. Furthermore, gross lesions, histology and MAP-culture from tissues were used to confirm infection status of each calf, and to investigate age-dependent susceptibility. Fifty calves were …
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Local immunopotentiation of the bladder in response to BCG immunotherapy
… we noted that BCG induces a mixed cytokine response, with a predominance of TH1 cytokines. Immune cells, bladder cancer cells and normal urothelium all produce cytokines and adhesion molecules, constitutively and on stimulation with BCG, both in vitro and in vivo. Booster instillations …
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Hepatitis B core (HBc) virus like particle (VLP) as a platform for innovation of chimeric adjuvant-free VLP vaccines targeting oncoviruses
… HCV core-HBc VLP induced strong epitope-specific immune response in mice compared with other reported vaccine candidates of EBV and HCV. The achieved immune responses of adjuvant-free EBNA1-HBc VLP and HCV core-HBc VLP groups were comparable to the groups with aluminium adjuvant. No side effect …
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The Efficacy of DNA Vaccine Using a Sindbis Virus-based Vector Against Nucleocapsid Protein of Hantaan Virus
… to be critical against viral infections, the cellular immune responses to HTNV are also assumed to be important for viral clearance. This study has examined the cellular and humoral immune responses against the HTNV nucleocapsid protein (NP) elicited by virus infection or DNA vaccination to …
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Metal binding to transferrin and immune reactions in Parkinson's disease
… to controls suggesting the activation of a cellular immune response. Furthermore, plasma neopterin was lower in treated compared to untreated PD patients, although the difference was not significant. There was no evidence for the activation of the humoral immune response in untreated or …
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Development and Utilization of Novel Immunologic Reagents for Infectious Disease Studies in the Guinea Pig
… in order to stimulate a robust humoral and cellular immune response. The most widely used animal model for the study of genital herpes is the mouse, however studies in this animal are limited to acute infection only. The guinea pig, a more robust model that closely mimics human disease, can …
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Biomarkers in sepsis and other severe infections
… actions by the microbiological agent and of the immune response mounted by the host. There is often a rapid onset, which may constitute a diagnostic and therapeutic challenge, whereas in other cases an extensive investigation over a long time period can fail to identify a causal microbial agent. …
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Investigating the role of B and T lymphocytes in the course of murine Leishmania Major infection
… that T-helper 1(Th1) and T-helper 2 (Th2) responses lead to resistance and susceptiblity to L. major respectively. Recent studies have now shown that B-cells are capable to producing key T-cell differentiating cytokines such as IL-4 and IFN-γ. More specifically, two new B-cell populations …
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Isolation And Characterisation Of Immunoglobulin Gene Superfamily Molecules From Lower Vertebrates (Fish)
… in vertebrates is a major mechanism of the immune system, which enables the vertebrates to discriminate self and non-self The most important feature of acquired immunity is the major histocompatibility complex (MHC) restricted-cellular immune response. This involves several important …
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Immunisierung gegen das Tumorantigen CEA: Vergleichende Untersuchung an Wildtyp- und CEA transgenen Mäusen
… models it is hard to decide whether part of the immune response is directed only to the foreign antigen (anti-allo). We established an animal model on H2d background using CEA transfected tumor cells and CEA transgenic mice. Transplanting CEA transfected cells s.c. in wild type mice clearly …
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The effect of nfa1 accination against Naeglearia fowleri infection
… protein within the target cells. To evaluate immune responses of nfa1-vaccinated mice, BALB/c mice were intranasally vaccinated with viral particles of each retroviral or lentiviral vector expressing nfa1 gene. DNA vaccination using viral vectors expressing nfa1 significantly stimulated the …
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Evolution-dependent SARS-CoV-2 vaccination success determined by neutralizing antibodies and reliability of point-of-care testing
… high avidity IgGs. We analyzed the humoral and cellular immune response after infection and vaccination and compared various vaccination schemes concerning IgG concentrations and neutralization titers. mRNA-based and heterologous vaccination schedules were superior as compared to homologous …
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Characterization of Host Immune Responses to Eimeria adenoeides Infection in Turkey Poults
… were aimed at investigating the biological and cellular immune response to <em>E. adenoeides</em> in turkey poults under different conditions of exposure. In experiment 1 (Chapter II), 20 day old poults were infected with 12.5 × 10<sup>3</sup> oocysts and shown to develop immunity when …
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Development of an oral DNA anti-cancer vaccine targeting an angiogenic peptide, proadrenomedullin N-terminal 20 peptide (PAMP)
… In the lung metastasis model, a humoral and cellular immune response was evidenced by the presence of significantly higher amounts of anti-PAMP IgGs and spleen CD8+ T cells in the PcPAMP-vaccinated mice. Although the number and size of lung metastases were similar between both experimental …
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Biochemical and Structural Characterization of Divergent Members of the Protein Kinase Family
… upon translocation into the host cell and uses cellular ATP and glutamic acid to inactivate another bacterial effector family, the SidE all-in-one ubiquitin ligases. By determining cryo-EM structures of the SidJ-SidE reaction intermediates, I show that SidJ uses its kinase-like active site to …
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T-cell responses to human papillomavirus in men with anal high-grade squamous intraepithelial lesions
… per year. To further understand the role of the cellular immune response in anal HSIL spontaneous regression, two assays were developed to measure systemic HPV16-specific T-cell responses and applied to a cross-sectional substudy of the Study of the Prevention of ANal Cancer (SPANC), a …
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Kinetik von NK-Zellen und gamma-delta-T-Zellen nach Infektion von Rhesusaffen mit Immundefizienzviren
… positive T cells as both belong to the cellular immune response early post HIV/SIV-infection. In addition both populations can activate the adaptive immune response by cytokine secretion. To obtain NK cells and gamma-delta-TCR positive T cells, peripheral blood mononuclear cells (PBMC) …
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Vaccination and immunological memory
… (Thmem) are pivotal in controlling humoral and cellular responses, therefore their longevity and response to vaccination are critical for maintenance of protective immunity. To probe the dynamics of the Thmem response to antigenic challenge, we investigated subjects following a booster injection …
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