Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 122 for “"Cellular growth"”.
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mTOR Signaling in Cellular Growth and Skeletal Muscle Maturation
A Serine/Threonine kinase, mTOR, is a cellular target of rapamycin and plays a role in cellular growth and proliferation by regulating translation through the phosphorylation of 4E-BP1 and S6K. Here, I investigated the function of mTOR for the activation of newly found S6K1 homologue, S6K2, and for …
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Regulation of cellular growth and identification of stromal gene signatures in breast cancer
… are disrupted, resulting in uncontrolled cell growth. Regulation of RNA stability and turnover is important to maintain cellular homeostasis and can be controlled by various mechanisms. During stress, the cell can form cytoplasmic complexes of proteins and RNAs, called stress granules, to …
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The role of cellular growth factor receptors in mediating gene transfer by adeno-associated virus 2 vectors
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Characterization of ABF-1 in C. elegans and regulation of cellular growth and ID3 by human ABF-1
… ABF-1 mediated regulation of both ld3 and cellular growth. Using a human ABF-1 stably transfected cell line, ID3 protein levels and transcript levels were shown to increase in response to overexpression of ABF-1 via western and northern blot, respectively. Flow cytometry analysis and …
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Measuring compositional and growth properties of single cells
… how individual cells grow and coordinate their growth with the cell cycle is of fundamental interest to understanding cell development, but various approaches for describing cellular growth patterns have often reached irreconcilable conclusions. In this thesis, a highly sensitive microfabricated …
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The inhibition of mammary epithelial cell growth by the long isoform of Angiomotin
Mammary ductal epithelial cell growth is controlled by microenvironmental signals in serum under both normal physiological settings and during breast cancer progression. Importantly, the effects of several of these microenvironmental signals are mediated by the activities of the tumor suppressor …
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Possible mechanisms controlling the intracellular level of inorganic polyphosphate during synchronous growth of chlorella pyrenoidosa
The endogenous respiration rate and the intracellular ATP/ADP ratio were determined during synchronous growth of a high temperature strain of Chlorella pyrenoidosa in order to correlate their activities with a proposed mechanism for the control of intracellular levels of inorganic acid-insoluble …
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Role of Ribavirin, an Anti-Viral Agent, In Eukaryotic Initiation Factor 4e (Eif4e) Subcellular Localization and Function
… factor 4E (eIF4E) is necessary for active cellular growth and catalysis of the rate-limiting step in cap-dependent protein synthesis3-5. Studies in the past decade have shown that eIF4E contributes to malignancy by selectively facilitating the translation of a specific set of mRNAs, those …
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The Role of Protein Phosphatases in Regulation of Drosophila S6 Kinase by Nutrient Signaling Pathways
The regulation of cellular growth is a highly complex, but fundamental, process and the inability of cells to initiate or repress cell growth in the presence of appropriate signals underlies many disease states including cancer and diabetes. Many studies have investigated the mechanisms by which …
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Modeling of gene regulatory networks controlling cell-fate decisions in Bacillus subtilis
… has distinct effects on Spo0A at different growth stages: under fast growth, KinC acts as a phosphate source and activates Spo0A; whereas under slow growth, KinC becomes a phosphate sink and contributes to decreasing Spo0A activity. Moreover, we showed that considering the single-cell level …
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The role of the tumor suppressor gene, NF2, in the development of malignant mesothelioma
… inactivation of NF2 plays a critical role in cellular growth dysregulation through altering normal regulation of MDM2 and thus p53 levels. To test this hypothesis, the role of the NF2 gene in regulating p53 function and cellular growth in "normal" mesothelial cells and in a mesothelioma cell …
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The role of the tumor suppressor gene, NF2, in the development of malignant mesothelioma
… inactivation of NF2 plays a critical role in cellular growth dysregulation through altering normal regulation of MDM2 and thus p53 levels. To test this hypothesis, the role of the NF2 gene in regulating p53 function and cellular growth in "normal" mesothelial cells and in a mesothelioma cell …
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Potential involvement of gap junctions in pathology of addiction
… addicted individuals. Gap junctions (GJs) allow cellular communication, indeed they are fundamental to regulate cellular synchronization, cellular growth and metabolic coordination in tissues. We analyzed the role of GJs proteins in the cocaine s mechanism of action and furthermore we verified …
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The regulation of RNA polymerase III transcription by protein kinase CK2
… III transcription plays a fundamental role in cellular growth and proliferation. Regulation of pol III output is mediated via a number of different mechanisms that can alter the activities of the transcription factors which are responsible for directing pol III transcription. Work presented in …
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Type II Estrogen Binding-Site Agonist: The Synthesis and Biological Evaluation of the Enantiomers of Methyl-Para-Hydroxyphenyllactate (MeHPLA)
… with MeHPLA, have been observed to suppress the cellular proliferation of estrogen sensitive MCF-7 breast cancer cells in vitro. Additionally, MeHPLA has been observed to suppress the growth of rat uteri in vivo. The high affinity of MeHPLA for the type II EBS suggests that this interaction is …
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Metabolic Control Analysis of Carbon Pathways
… not fluxes of carbon through UDP-glucose during cellular growth but also calculates the control and elasticity coefficients of the variables embedded in the metabolic web under study. The practical application of this model consists in its ability to identify enzymes with a higher regulatory …
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Biocompatible silicon nitride thin films for self-rolled-up microtube technologies: guiding neurons
… Extending this platform beyond sensing to cellular growth guidance, we find properties unique to this material system and superior to existing platforms. The SiNx s-RUM platform can be used for applications from sensing to culturing, from disposable electronics to implants, and from …
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Computational analysis of genomic data provides insight into cell sensitivity to BCNU-Induced DNA damage
… response to DNA damage plays a critical role in cellular responses to exogenous stress, and is a key component of resistance to therapeutics in cancer cells. Understanding the underlying mechanisms, as well as the differences in DNA damage responses, between cell lines can have implications for …
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Computational analysis of genomic data provides insight into cell sensitivity to BCNU-Induced DNA damage
… response to DNA damage plays a critical role in cellular responses to exogenous stress, and is a key component of resistance to therapeutics in cancer cells. Understanding the underlying mechanisms, as well as the differences in DNA damage responses, between cell lines can have implications for …
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Potassium and Sodium Movements Related to Growth State and Malignant Transformation in Cultured Chicken Embryo Cells
… binding were shown to be dependent on the cellular growth state but unaffected by malignant transformation; potassium influx and ouabain binding values in growing normal and transformed chicken embryo fibroblasts were 1.5 to 1.8-fold greater than in density-inhibited cells. Growing normal …
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