Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 31 for “"Cellular dynamics"”.
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Quantitative characterization of cellular dynamics in wound healing using multimodal microscopy
In this thesis, cellular dynamics in skin under various pathological conditions were characterized utilizing multimodal multiphoton and optical coherence microscopy (MPM OCM). Through these studies, additional insights were gained regarding the complex relationships among different skin …
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Light in Living Systems: Ultra-Weak Photon Emission and Fluorescence Lifetime Imaging of Cellular Dynamics
… biological perspectives to advance the study of cellular light. Part I provides a critical review of UPE, charting its discovery, mechanistic links to reactive oxygen species (ROS), and the evolution of detection technologies. Part II provides comparative analysis of photomultiplier tube (PMT), …
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Cellular Dynamics and Disease Outcome of Type 3 Streptococcus pneumoniae Clinical Isolates Differ Between Strains
… 3 pneumococcal isolates and observed the immune cellular dynamics as well as capsule production, and saw that even with the same serotype immune responses can differ.
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Cellular patterns during leaf development
… the reproducibility of form also happens at the cellular level and cellular patterns are evident in the temporal as well as the spatial scales. Understanding the principles underlying these cellular patterns will contribute to linking the individual cell dynamics to the collective phenomenon of …
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MITO: ROBUST INFERENCE OF MITOCHONDRIAL PHYLOGENIES AND CLONES
… emerged as a powerful approach to study these cellular dynamics, especially in primary tissues. In this scenario, mtDNA variants (MT-SNVs) have gained special attention recently, due to their low-profiling costs and compatibility with other informative cell-state modalities. This thesis …
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Collective cellular behavior on curved surface
… While most of existing research of collective cellular behavior are on flat two dimensional (2D) space, most native biological systems however are intrinsically curved, including mature respiratory bronchioles, alveoli, and embryonic tissues. There are fundamental reasons to suspect that such …
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Alveolar stem cell dynamics and regulatory mechanisms in homeostasis and early oncogenesis
… of cancer-related mortality worldwide, yet the cellular dynamics and molecular mechanisms governing tumour initiation and progression remain elusive. Although alveolar type II (AT2) cells, which act as stem cells in the alveolar epithelium, have been identified as key cells of origin of LUAD, …
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Interpreting Raman spectra using machine learning: towards a non-invasive method of characterizing single cells
… fibroblasts (MEFs) undergoing a dynamic cellular reprogramming process. Using a multi-modal, supervised learning approach, we provide evidence that Raman spectra can accurately resolve microbial cell types. This thesis also presents a robust computational pipeline to preprocess Raman …
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Cellular and Molecular Mechanisms of Cardiac Chamber Maturation in Zebrafish
… with life. An improved understanding of the cellular and molecular processes that build the heart is essential to elucidate the causes of congenital defects and to design appropriate therapies. Relatively little is known about how the cardiac chambers adopt distinct forms to follow their …
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High Resolution Phase Imaging using Transport of Intensity Equation
… QPI provides objective measurement of the cellular dynamics and enables imaging the specimen with high contrast. Transport of Intensity Equation(TIE) is a powerful computational tool for QPI because of its experimental and computational simplicity. Using TIE, the phase can be quantitatively …
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Cell Migration and Morphogenesis during Formation and Repair of Zebrafish Skeletal Muscle
… In vivo cell tracking revealed that cellular dynamics during somite morphogenesis constitute a potential force, capable of driving somite shape changes. Tracked anterior border cells (abc) were observed migrating to the lateral somite surface were they are though to form the …
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Investigation of cell movement and the associated cytoskeleton during chick gastrulation and somitogenesis
… in cell migration. This thesis concentrates on cellular dynamics and organisation (and the associated cytoskeleton) during chick gastrulation and somitogenesis. The aims of this project were to a) further characterise the cytoskeleton in cells that ingress into the avian primitive streak. b) …
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Advances in Telecentric Digital Holographic Microscopy: From Theoretical Foundations to Biomedical Applications
… These advancements are pivotal in observing fast cellular dynamics, particularly in tracking individual bacterial cells within biofilms, thus offering new insights into microbial processes. In summary, the enhancements in TDHM articulated in this thesis not only provide a deeper understanding of …
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Computational Systems Biology Analysis of Cell Reprogramming and Activation Dynamics
… science that systematically measures cellular dynamics on different levels of genome, transcriptome and proteome. Along with this transition emerges the interdisciplinary field of systems biology, which aims to unravel complex interactions in biological systems through integrating …
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Effects of Keratin Biomaterial Therapeutics on Cellular and Inflammatory Mechanisms in Injury and Disease Models
… the influence of keratin biomaterials on cellular and inflammatory mechanisms in two models of injury and disease. Rodent models of blast induced neurotrauma (BINT) and severe osteoporosis were used to inform the development of 2D and 3D in-vitro models of macrophage/endothelial cell …
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Biochemical analysis of proteins in the telomere maintenance pathway
… to operate correctly and to help achieve cellular homeostasis. Distinct protein assemblies are nucleated at telomeric DNA to both guard the ends from damage and lengthen the DNA after replication. In yeast, Cdc13 recruits either Stn1-Ten1 to form a protective cap or the telomerase …
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EFFECTS OF AT1R ANTAGONIST L-158,809 ON NORMAL BRAIN TISSUE INJURY FOLLOWING WHOLE-BRAIN IRRADIATION
… by injury to irradiated normal brain tissue. The cellular and molecular mechanisms underlying radiation-induced normal brain tissue injury have not been fully elucidated. Neuroinflammation, in the form of microglial activation, and decreased hippocampal neurogenesis frequently occur in animal …
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Characterizing Modified Nucleosides in RNA by LC/UV/MS
… of modified nucleosides as a function of varying cellular conditions and can be used to explore the dynamics of RNA modification. These methods were optimized and characterized, then used to compare the global modification status of tRNA and rRNA under normal and heat shock conditions.</p><p>It …
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Microfluidic-based 3D cell culture for studies of biophysical and biochemical regulation of endothelial function
… with the optical resolution to monitor the dynamics of individual cells or small populations is lacking. In this thesis, we developed a novel multiparameter microfluidic-based cell culture platform. The system permits 2D or 3D culture of cells on/in biologically-derived or synthetic hydrogel …
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Visualizing the dynamics of HIV-specific cytotoxic T-cells in extracellular matrix
… been defined in the absence of physiological dynamics and migration. Furthermore, longterm dynamics of single cells have been inaccessible in vivo, where brief imaging durations have been achieved (-30-60 min). Presently, several key aspects of CTL dynamics and function remain unknown: whether …
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