Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 16 of 16 for “"Cellular analysis"”.
-
Luminescent Quantum dots for Cellular Analysis
… associated with use of organic fluorophores in cellular studies. Quantum dots show high photostability, high emission quantum yield, narrow and symmetric emission peaks and size-dependent wavelength tunability. The objective of my PhD studies was to develop CdSe/ZnS quantum dot-based probes and …
-
Microfluidic technology for cellular analysis and molecular biotechnology
… to offer an ideal platform for biological analysis of a low number of cells. The technological advances in microfluidics have allowed both forming of valves, mixers and pumps and integrating of optic and electronic components into microfluidic devices to construct complete and functional …
-
Genetic and cellular analysis of modulated behaviors in Caenorhabditis elegans
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1996.
-
Cytoplasmic incompatibility in Drosophila: Biochemical and cellular analysis of factors influencing its expression
Wolbachia, an endocellular bacterium closely associated with cytoplasmic incompatibility in insects (CI), was purified from infected eggs and microinjected into two strains of D. melanogaster, a highly inbred laboratory strain (Oregon R), and a recently caught wild-type strain from Arizona. …
-
Applications of aspiration lung biopsy with special reference to the pathogenesis of the resolution of acute and chronic lobar pneumonia
… across a paper on this subject. The title was: "Cellular analysis of the aspiration lung biopsy from normal and some pathological conditions by Z. Godlowski" (1949). The very term "lung biopsy" conjures up the picture of a needle being introduced into an air filled, very vascular structure where …
-
EVALUATION OF THE HEPATIC MICROENVIRONMENT BEFORE AND AFTER ANTIVIRAL THERAPY FOR CHRONIC HEPATITIS C
… reducing complications such as hepatocellular carcinoma and mortality. However, challenges persist, including the absence of a vaccine and increasing infection rates associated with intravenous drug use. This study investigated gene and protein expression changes in the hepatic …
-
N-linked glycosylation is fundamentally linked to the surface expression of neuroligins
… of each NLGN isoform. Biochemical and cellular analysis revealed the NLGN4-R101Q variant to be immaturely glycosylated and mistrafficked, retained in the ER similarly to N-glycan site mutants. In neurons, the mistrafficked R101Q variant failed to reproduce the excitatory synaptogenic …
-
Nanoparticle probes for the study of biomolecular interactions
… dyes, increasing their potential in multiplexed analysis. Biomolecular SERRS detection was also extended towards cellular analysis using antibody functionalised gold nanoparticles for targeting cell surface receptors. Conjugation was achieved using a novel linker incorporating a chromophore …
-
Machine Learning Methods for Brain Image Analysis
… (EM) images and stacks, and integrative analysis of the gene expression and synaptic connectivity in the brain. I propose to use deep learning algorithms for the 2D segmentation of EM images. I designed an automated pipeline with novel insights that was able to achieve state-of-the-art …
-
Multi-scale imaging and informatics pipeline for in situ pluripotent stem cell analysis
… in situ quantitative single-cell image analysis. This dissertation offers a tool for analyzing the spatial population context of hPS cells that integrates automated fluorescent microscopy with an analysis pipeline. It enables high-throughput detection of colonies at low resolution, with …
-
An in vivo study of GTF2IRD1 function and its contribution to the physical features of Williams Beuren Syndrome
… phenotypes using direct physiological and cellular analysis methods. A detailed analysis of Gtf2ird1 expression in the inner ear and the skin was conducted. A comprehensive analysis of hearing capacity in Gtf2ird1 knockout mice was carried out by examining the auditory brainstem response …
-
Therapeutic Approaches to Insulin Resistance and Type 2 Diabetes
… of its predicted mode of action. Through cellular analysis this study has established the mechanism by which this is achieved. RTC-1 was found to inhibit complex I of the mitochondrial respiratory chain (NADH:ubiquinone oxidoreductase), leading to a likely increase in the AMP to ATP ratio …
-
The role of Lynx1, an endogenous modulator of cholinergic transmission, in NMJ development, maintenance, and repair
… the activity of nAChRs at NMJs. Molecular and cellular analysis revealed that Lynx1 levels increase in skeletal muscles, specifically at NMJs, during development. Its expression pattern also closely mirrors changes in cholinergic transmission in vivo and in vitro. As expected, I found by …
-
Connexin43 as a novel therapeutic target in age-related macular degeneration
… protein in mammals playing a role in intercellular communication. Increased Cx43 expression in the vasculature and astrocytes has been reported for many human central nervous system injuries. However, the association between Cx43 and AMD remains unclear. Intense light exposed albino rats …
-
How the Heart Grows: From Multi-scale Data to a Multi-scale Model
… have been carried out at different levels of subcellular, cell, tissue, and organ. However, looping is a very complex process and, despite a great deal of experimental data and research, the underlying mechanisms controlling the looping phase are unclear. In this thesis, a novel workflow is …
-
A Novel Interleukin-15 Receptor Antagonist for the Treatment of Rheumatoid Arthritis
… as TNF-α, IL-6, and IFN-γ. Immunofluorescence analysis further confirmed reduced infiltration of CD3+ T cells and CD19+ B cells into joint tissues, highlighting the compound’s immunomodulatory effects. In Aim 2, we investigate the plasma stability of IFRA3Q1 and further evaluate the …