Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"Cellular activation"”.
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Mechanical Deformation of the Extracellular Matrix Mediates Cellular Activation and Mechanotransduction
… is constantly applied to the cardiac extracellular matrix (ECM) at the cellular level (i.e. myocyte contraction and/or fibroblast focal adhesions) or globally through hemodynamic pressures. While mechanical load can be an important factor in maintaining tissue homeostasis, little is known …
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Neuroanatomical specificity of prolactin-induced hyperphagia and expression of fos-like immunoreactivity following central administration of prolactin
… A second experiment investigated the pattern of cellular activation, as revealed by Fos-like immunoreactivity (Fos-lir), in the PVN, VMH, and MPOA of female rats following treatments of varying lengths of icv administration of PRL. Ad libitum fed virgin female rats were given 1, 7 or 15 icv …
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Combinatorial Regulation of Signal-Induced CD45 Exon Repression by hnRNP L and PSF
… hnRNP L. ESS1 is also sufficient to confer the activation-induced increase in exon repression, and this document describes two mechanisms responsible for mediating this effect. First, hnRNP L silencing function is slightly increased in activated cells as compared to resting cells. Additionally, …
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Studies on immunity in the male genital tract
… immune cells from the male genital tract. Cellular activation and inflammation in the genital tract have important implications for both transmission and acquisition of HIV, since they provide target cells for viral replication. Thus, the second and third aim of this study was to …
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Impact of immune activation and inflammation on the susceptibility to HIV infection and disease progression in HIV serodiscordant and seroconcordant couples
… HIV infection or progression. The role of immune activation and chronic inflammation in the modulation of HIV acquisition risk and/or rate of HIV disease progression has been proposed as one of the most important mechanisms determining risk and pathogenesis but is not fully understood. A state of …
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Investigations of Insulin-Like Growth Factor I Cell Surface Binding: Regulation by Insulin-Like Growth Factor Binding Protein-3 and Heparan Sulfate Proteoglycan
… aim of this text is to gain insight on how cellular activation by a insulin-like growth factor (IGF-I), in the presence of insulin-like growth factor binding protein-3 (IGFBP-3), is influenced by heparan sulfate proteoglycans (HSPG). Initial research will be presented, assumptions and …
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The effects of the noradrenaline reuptake inhibitor atomoxetine on circadian rhythms in mice.
… whether treatment with these drugs alters cellular activation in brain areas implicated in the circadian timekeeping system. The effects of atomoxetine on locomotor circadian rhythms in mice were examined under free-running conditions (to look at the endogenous circadian clock without …
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Computational Systems Biology Analysis of Cell Reprogramming and Activation Dynamics
… science that systematically measures cellular dynamics on different levels of genome, transcriptome and proteome. Along with this transition emerges the interdisciplinary field of systems biology, which aims to unravel complex interactions in biological systems through integrating …
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The role of mechanical loading in chondrocyte signaling pathways
… of mechanical loading trigger differential intracellular signaling pathways at sub-cellular levels, which consequently lead to selective matrix synthesis and degradation. Furthermore, it is not known whether the loading-magnitude dependent responses are linked to degenerative diseases such as …
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Cellular and Genetic Bases of Cold Nociception and Nociceptive Sensitization In Drosophila Larvae
… neurons are multimodal, and the level of cellular activation determines the behavioral output to different stimuli.</p> <p>To study cold nociceptive sensitization, we used a "sunburn assay" which exposes the dorsal side of the larva to UV-damage, and found larvae display a dramatic shift …
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Investigation of The Functional Impact of Anti-Pd-1 On Tumor-Infiltrating Lymphocytes (Til) and Mapping of Tumor Genomic Features Relevant For Response to Til Therapy
<p>With the growing use of both cellular and antibody-based immunotherapies, it has become more important to uncover biomarkers to predict patient response to therapy and ideally aid in patient selection for specific therapeutics, thereby enhancing treatment outcome. At MD Anderson, we have a 43% …
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Cerebrovascular and Neuronal Cellular Consequences of Amyloid-β Induced Nuclear Factor-κB Activation
… characterized by brains that have developed extracellular plaques and intracellular tangles. The extracellular plaques are composed of aggregated amyloid-β protein (Aβ), which is widely believed to be the underlying cause of the disease. Mounting evidence suggests the small, soluble aggregates of …
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ROLES OF MAST CELL G PROTEIN-COUPLED RECEPTOR KINASE 2 (GRK2) IN ALLERGY AND INFLAMMATION
… stimulation, GPCRs couple to G proteins to cause cellular activation but most receptors are also phosphorylated by GPCR Kinases (GRKs) to promote their desensitization. MCs express GRK2 but its role on the regulation of MRGPRX2/B2 and FcRI function has not been studied in detail. For the present …
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The Role of Apolipoprotein A-I in the Modulation of Cholesterol and Immune Homeostasis
… DKO LN T cells had increased expression of activation markers and proliferation of CD4+CD44high T cells was increased. Plasma autoantibodies were also increased. We concluded that, in the absence of apoA-I, diet-fed DKO mice develop an autoimmune phenotype. These data suggest that apoA-I can …
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Defining How Polymorphisms at the Slam Family Locus Affect NK and T Cell Function
… in regulating several immune functions such as cellular activation, cytokine secretion, cytotoxicity, and apoptosis. Thus, it is not surprising that dysregulation of this family of receptors is associated with disease states such as systemic lupus erythematosus (SLE) and X-linked …
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Characterization of Chronic Glucocorticoid Exposure on Natural Killer Cell Function: A Model for Stress Induced Alterations on the Epigenetic Landscape
… were primed for increased transcription upon cellular activation demonstrating increased H4K8Ac, increased accessibility of the chromatin structure, and concomitant loss of HDAC1 and HDAC3 at regulatory loci. These results demonstrate chronic GC exposure to impact NK effector function through …
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The RNA-Binding protein PTBP1 plays a role in the activation of mouse CD8 T cells
… a pivotal role in immune responses against intracellular pathogens, including viruses and bacteria, and in tumour surveillance. After encountering an antigen, CD8 T cells undergo cell growth, clonal expansion, and acquisition of effector functions. These steps are a result of controlled gene …
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Antibody-Effector Functions in Antiviral Response
… function and bridges the humoral with the cellular components of immunity. While the Fc domain of immunoglobulin G (IgG) has historically been considered to be relatively constant, recent studies have demonstrated that in conjunction with IgG subclasses, the single conserved N-linked glycan …
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Integration Sites in the Persistence of Latent HIV-1
… host immunity and virus-induced cell death. Cellular and molecular characterization of the latent reservoir is challenging because latently infected cells are exceedingly rare and express no known surface marker. Moreover, the infected cell pool is dominated by cells containing defective …
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Exploring glucagon-like peptide 1-secreting L-cells as signal transducers in the microbiota-gut-brain signalling pathways
… of L-cells. Through calcium imaging, I explored cellular activation of NCI-H716 cells in response to B. breve NCFB 2258 secretions, and ELISA was used to determine the effects of B. breve NCFB 2258 products on the secretion of GLP-1 from NCI-H716 cells. Results: Although exposure to …
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