Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"Cellular Thermal Shift Assay (CETSA)"”.
-
Development of peptide inhibitors as molecular therapeutics against tandem-repeat proteins
… attempted to expand the range of biophysical assays to assess ligand binding to TNKS ARCs. We then designed and tested a set of linear and chemically constrained peptides for their ability to bind to the ARCs. The APC/C is an E3 ubiquitin ligase that has broad substrate-specificity via its two …
-
Regulating the stabilities of NOD1 and NOD2, two innate immune receptors, with sugars and chaperones
… by the enzyme O-GlcNAc transferase (OGT). A cellular thermal shift assay (CETSA) typically used to detect protein-ligand binding was adapted in order to monitor the stability changes caused by O-GlcNAcylation, and it was found that wild type NOD1 and NOD2 were stabilized when modified by OGT. …
-
Investigating the effect of a small molecule, Inhibitor of Nuclear Import (INI-43) as a pan-cancer treatment
… the nucleus and plays an important role in other cellular processes such as mitosis and mitotic spindle assembly, DNA replication and cell cycle progression. Previous studies in our laboratory have reported that KPNβ1 is overexpressed in cervical and oesophageal cancer and is important for cancer …
-
Small molecule inhibitors of lactate dehydrogenase A as an anticancer strategy
Embargo set by: Seth Robbins for item 73141 Lift date: 2017-01-21T19:56:18Z Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD system