Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 187 for “"Cellular Proliferation"”.
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Biochemical investigations on cellular proliferation
The investigations described here were begun at the suggestion of Professor G. F. Marrian and. Professor J. R. Learmonth to examine the relationship between ribonucleic acids (and their derivatives) and the processes of tissue growth (including wound healing).
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Evidence That Relaxin Promotes Cellular Proliferation in the Lower Reproductive Tract of the Pregnant Rat
… is brought about, in part, by promoting the cellular proliferation of cervical epithelial and stromal cells.
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Altered DNA Repair, Antioxidant and Cellular Proliferation Status as Determinants of Susceptibility to Methylmercury Toxicity in Vitro
… kidney (HEK) cells; reciprocal in vitro cellular models with deficient and enhanced ability to repair oxidatively damaged DNA respectively. When spontaneously-immortalized wild-type and Ogg1-/- MEFs were exposed to environmentally relevant, low micromolar concentrations of MeHg, both …
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The Role of Hormones and Ions in the Physiological Control of Cellular Proliferation in Rat Erythropoietic and Lymphopoietic Tissues
… adenosine 3’, 5’ — monophosphate in the intracellular mediation of mitogenic stimulants. Proliferative activity in the thymus following erythropoietic stimuli has a number of parallels with that in bone marrow. The functional Significance of this observation is not clear. Thus the hormones of …
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Deciphering the Functional Collaboration of Mid and bric-a-brac 2 as Potential Regulators of Cellular Proliferation Within Adult <i>Drosophila</i> Ovaries
… evidence suggests that Tbx20 regulates cell proliferation within the embryonic chamber of the mouse myocardium; <em>Tbx20</em><sup>-/-</sup> null mice exhibit increased expression of <em>Tbx2</em> with a concomitant decrease in <em>N-myc-1 </em>expression, a proto-oncogene. These disturbed …
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A two-pronged approach towards the development of novel therapeutics for advanced endometrial cancer
… is a receptor tyrosine kinase that influences cellular proliferation, migration and apoptosis. MUC1 increases EGFR gene expression, mRNA levels, protein levels and signaling in endometrial cancer cell lines. Consequently, MUC1 expression is associated with increased EGF-dependent cellular …
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Identification and functional characterisation of novel APC/C interacting proteins
… E3 ubiquitin ligase complex that regulates cellular proliferation through its ability to target essential cell cycle regulators such as cyclin A, cyclin B, securin and S-phase kinase-associated protein 2 (SKP2) for proteasomal-dependent degradation. APC/C substrates and coactivators are …
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The Time-Course of the Effects of Growth Hormone During Zebrafish (<i>DANIO RERIO</i>) Auditory Hair Cell Regeneration
… of GH in hair cell regeneration and the possible cellular mechanisms of this regeneration, groups of zebrafish were divided into baseline (no sound exposure, no injection), buffer-injected and GH-injected groups. Buffer- and GH-injected fish were exposed to a 150 Hz tone at a source level of 179 …
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Effects of Leptin on the Rat Cervix
… dry weight. Leptin also is capable of increasing cellular proliferation and collagen accumulation in the cervix. However, the studies conducted indicate that leptin may not modulate the extra-cellular matrix through matrix metalloproteinases, but leptin appears to play a role in the …
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The Roles of Midzone and Peripheral Mitochondrial Fission in Pulmonary Arterial Hypertension
… for maintaining mitochondrial health, regulating cellular processes like proliferation and apoptosis. Disrupted fission is associated with development of cardiovascular diseases, including pulmonary arterial hypertension (PAH), ischemia-reperfusion injury, cardiac hypertrophy, and heart failure. …
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Low-Density Lipoprotein Receptors in Signaling Modulation and Development
… the regulation of signaling pathways at the intracellular, extracellular and transcriptional level. These regulations confer viability, control the cellular proliferation at several molecular steps, and allow for proper organ formation by moderating and integrating cellular signaling pathways. / …
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Isolation of Therapeutic Antibodies Against Microseminoprotien to Potentially Overcome Resistance to Anti-Angiogenic Therapy
… Specifically, it could result in a reduction in cellular proliferation and tumor endothelial cell migration in hypoxic environments. . Specifically, it could result in a reduction in cellular proliferation and tumor endothelial cell migration in hypoxic environments. If validated in animal …
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Selective targeting of MYC by antisense oligonucleotides
… hallmark expression programs responsible for cellular proliferation, growth, metabolism, and evasion from apoptosis. MYC dysregulation occurs genetically, epigenetically, and post-transcriptionally through a wide variety of mechanisms. Despite its well-characterized properties as a …
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The growth-arrest-specific protein gas7 potentiates neuronal differentiation
… This effect was exerted independently of cellular proliferation, as gas7 did not affect cell cycle progression. Endogenous gas7 expression was induced during neuronal differentiation of NT2 cells with retinoic acid, suggesting a role for gas7 in neuronal development. Finally, gas7 …
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IDENTIFICATION OF HCMV UL97 IN GBM CELL LINES AND A POSSIBLE ROLE FOR GANCICLOVIR
… demonstrate that it significantly decreases cellular proliferation in UL97 expressing cells. This project identifies a new role for HCMV in GBM and suggests a possible future treatment option.</p>
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The Role of ERp57 in Hras Intracellular Trafficking and Function.
… player in signal transduction that mediates cellular proliferation and differentiation. Recent evidence has shown that lipid and non-lipid modified domains participate in Ras traffic and that plasma membrane association is mediated by vectorial vesicular transport from the endomembrane …
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Calcium Influx via the T-Type Calcium Channel Plays a Permissive Role in Proliferation of Mouse Embryonic Hl-1 Cells
… through the T-type calcium channel inhibits cellular proliferation. Drug dosage studies demonstrate that the T-type calcium channel responsible for this effect is Cav 3.1. Furthermore, blocking the calcium influx through the T-type calcium channel arrests cells in the G2/M phase of the cell …
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Therapeutic Effects of Ormeloxifene in Cervical Cancer Carcinogenesis
… that ormeloxifene significantly decreased the cellular proliferation and clonogenic potential of cervical cancer cells. Ormeloxifene also reduced the cellular motility and induced the apoptosis via targeting PI3K-Akt signaling in these cells. Furthermore, ormeloxifene modulated the HPV induced …
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Development of a human plasmacytoma cell line with inducible expression of activated B-cell factor-1
… (ABF-l), is a transcription factor involved in cellular proliferation and differentiation. ABF-1 shows patterns of expression that are stimulated in activated B cells, which may suggest ABF-1 is involved in the regulation of B-cell differentiation. To investigate the functional role of ABF-1, we …
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The role of eukaryotic initiation factor 5A and its cellular localization in developing Zea mays plant tissue.
… that has been implicated in a wide variety of cellular activities, but its primary role, especially its role in translation, has been a mystery. Investigation of its localization in developing maize endosperm and root and leaf tissue have reinforced the idea that eIF5A has at least a secondary …
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