Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 66 for “"Cellular Physiology"”.
-
Daily organisation of cellular physiology by mTOR kinase
… all levels of biological scale and organise physiology to accommodate the different environmental and energetic demands of day and night. In mammalian cells, the mechanistic target of rapamycin complex (mTORC) activity exhibits daily rhythms both in vivo and in cultured cells. Circadian …
-
Integrated characterization of cellular physiology underlying hepatic metabolism
The macroscopic metabolic phenotype of a cellular system, such as insulin resistance, is the result of the integration of many hundreds or thousands of preceding cellular events, which culminates in the cell's final response to a perturbation in the environment. The data provided by DNA microarrays …
-
Nonstationary metabolic flux analysis (NMFA) for the elucidation of cellular physiology
… determining these flux distribution through a cellular reaction network. However, MFA has experimental limitations (most notably, a requirement for isotopic steady state) that restrict the scope of biological contexts in which it can be applied. Nonstationary metabolic flux analysis (NMFA) has …
-
Zinc ion homeostasis in cellular physiology and experimental models of traumatic brain injury
… (TBI) is the understanding of the secondary cellular injury that contributes to cell death. Whether zinc ions are toxic or protective in TBI is controversial. As an essential human micronutrient, zinc is needed for the structure and function of at least 3,000 proteins, and thus affects almost …
-
Building integrated cell-based microsystems : fabrication methodologies, metrology tools and impact on cellular physiology
… of electric-field effects on cell physiology in microsystems. Materials for biological microsystems have been dominated by the elastomer polydimethylsiloxane (PDMS) and the photopolymer SU-8 which form the core of soft lithography based fabrication. The design of highly integrated …
-
Beyond MICS: Determining the Role of Porin Production and β-Lactamase Expression in Resistance and Cellular Physiology of Klebsiella pneumoniae
… known about how β-lactamase expression affects cellular physiology and whether these fitness costs may relate to other resistance or virulence mechanisms. The purpose of this dissertation was two-fold. First, to determine the extent to which β-lactamases and outer membrane porins affected …
-
Massively multiplexed imaging probes for comprehensive single-cell analysis
… microscopy techniques are widely used to study cellular physiology in their native tissue environments. In particular, the use of fluorescent probes to tag different cell populations, subcellular compartments, specific proteins and nucleotide sequences has enabled examination of cellular …
-
Insights into the consequences of chromosome gains and losses in S. cerevisiae
… and developmental defects, while at a cellular level, aneuploidy causes proliferative defects and is detrimental to cell fitness. However, aneuploidy is also associated with cancer, a disease of uncontrolled proliferation. Understanding the effects of aneuploidy on cellular physiology …
-
Macromolecular Organization and Cell Function: A Multi-System Analysis
… macromolecules. A fundamental understanding of cellular physiology will depend not only upon a reductionist analysis of the chemistry, structure, and function of individual components and subsystems, but also on a sagacious exegesis of the dynamic and emergent properties that characterize the …
-
"Effects of nonthermal plasma on prokaryotic and eukaryotic cells"
… plasma was found to have significant effects on cellular physiology. Plasma-mediated germicide in prokaryotic cells and stimulatory and proliferative effects in eukaryotic cells were determined to be dose-dependent phenomena.
-
Investigating the effects of impermeant anions on the electrical and computational properties on neurons
… the influence of impermeant anions on neuronal cellular physiology, passive cable properties, and synaptic integration. Spatial differences in the average charge of impermeant anions result in a nonisopotential dendrite with ionic microdomains. At steady state local discrepancies in membrane …
-
Regulation of DnaA as a transcription factor by modulation of cooperative binding, and by arrA, an antisense RNA
… to disrupt replication initiation but affected cellular physiology and expression of DnaA targets. In particular, arrA was required for proper sporulation. I also asked whether two of the previously described mechanisms regulating DnaA as the replication initiator in B. subtilis affect its …
-
Biochemically realistic MD and kinetic models of the Rhodobacter sphaeroides bc1 complex
… function, and medically important roles in cellular physiology, cardiovascular disease, apoptosis, and diseases associated with aging.
-
High resolution metabolic flux determination using stable isotopes and mass spectrometry
Cellular physiology is a combination of many different functions that have to be accurately probed individually and then precisely correlated to each other, in order to reveal the language used by the cell to communicate changes from the environment to gene expression and vice versa. Genes are …
-
Pathological features of mitochondrial respiratory chain dysfunction
… Given the role of mitochondria in maintaining cellular physiology, mitochondrial dysfunction often leads to disease. One major class of mitochondrial pathologies is caused by defects in the mitochondrial respiratory chain (RC). Yet while the genetic etiologies of these RC disorders are …
-
Investigations into the Role of Paf1 Complex Proteins in Drosophila Ovaries
… entirely different transcriptomes and therefore cellular behaviors has piqued the curiosity of many researchers creating the whole field of Chromatin Biology. The difference in behavior of otherwise identical cells comes from an array of covalent modifications to protein spools wrapped by DNA in …
-
Distributional Fingerprinting of Cell Population Phenotypes and Drug Activities
… measurements as an information source of cellular physiology and network dynamics. While gene expression from a signaling network in a single cell is stochastic and unpredictable, the distribution of the gene expression in a sufficiently large cell population is uniquely determined by the …
-
Aneuploidy causes proteotoxic stress in Saccharomyces cerevisiae
… to date. How aneuploidy affects organismal and cellular physiology is only beginning to be understood. Aneuploidy also has a profound impact on human health; it is the leading cause of mental retardation and spontaneous abortions and a key characteristic of cancer, as more than 90% of all solid …
-
Ray Tracing Confirms the Optical Properties of the Bovine Lens Are Actively Maintained by the Microcirculation System
… tissue level of the underlying state of the cellular physiology of the lens. To investigate this hypothesis, I have developed a novel laser ray tracing (LRT) system that allows the optical properties of isolated bovine lenses maintained in organ culture to be measured. A fully automated LRT …
Page 1 of 4