Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 38 for “"Cellular Migration"”.
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Three-Dimensional Biomimetic Patterning to Guide Cellular Migration and Organization
… spatial and biochemical control of engineered cellular architectures, such as the microvasculature. Intricate tools that allow for the three dimensional (3D) manipulation of biomaterial microenvironments will be critical for organizing cellular behavior, directing tissue formation, and …
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A computational and experimental study of HER2-signaling effects on cellular migration and proliferation
… of [approx.] 1014 cells that interpret extracellular information and respond with such behavior as migration, proliferation, apoptosis, or differentiation. Thirty years of research in the related fields of biochemistry, molecular biology, and genetics have demonstrated that, in most cases, …
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Chemical Tagging of Surface Composition Gradients With Polystyrene Nanospheres and the Extracellular Matrix Protein Fibronectin for the Study of Cellular Migration
… show great promise as tools in understanding cellular adhesion and motility. Gradients in surface electrochemical potential were prepared by poising two ends of a thin Au film at different potentials relative to a common solution Ag/AgCl reference couple, resulting in a linear surface …
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The Effects of Gain of Function Mutant p53 and p63 on EPS8 and CXCL5 Expression in Head and Neck Squamous Cell Carcinoma
… decreased EPS8 expression, CXCL5 expression, and cellular migration associated with the loss of GOF mutant p53. This indicates an enhancing role of GOF mutant p53 in cellular migration and expression of these target genes. The loss of GOF mutant p53 was also associated with decreased EPS8 and …
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Caged phosphopeptides and phosphoproteins : probes to dissect the role of phosphorylation in complex signaling pathways
… mechanism in signal transduction pathways and cellular migration. Current genetic strategies for the study of phosphorylation, including gene knockout and point mutation, are limited in providing temporal information. As a complement to these techniques, the synthesis and semisynthesis of …
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Cip4 and Src In Promoting The Migration and Invasion of Breast Cancers
Cellular invasion represents a critical early step in the metastatic cascade, and many proteins have been identified as part of an “invasive signature.” The non-receptor tyrosine kinase Src is commonly upregulated in breast cancers, often in conjunction with overexpression of EGFR. Signaling from …
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The Biophysical Role of the Cellular Glycocalyx: Engineering Glycoproteins to Control Cell-Surface Properties
… as a biomaterial is lacking. Coating the cellular surface, the glycocalyx is uniquely positioned to impact many different cell-surface properties including regulation of cell-cell and cell-extracellular matrix interactions, cell-surface features, and cellular migration. Throughout this …
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BUBR1 in Cardiac Biology: From Cardiogenesis to Adult Heart Function and Aging
… in cardiac morphogenesis, cardiac aging, intercellular communication, and wound healing, uncovering novel regulatory pathways that contribute to both developmental and degenerative cardiac conditions. Our findings demonstrate that BubR1 is indispensable for embryonic cardiac development. …
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Effect of Diabetes Mellitus on Ocular Surface Tight Junctions and Glycocalyx
… performed to quantify barrier functions and cell migration. Gene and protein expression of tight junction proteins: claudin-1, claudin-2, claudin-3, ZO-1, ZO-2, ZO-3, and occludin was quantified using real time PCR and western blotting. Type I diabetes was induced in mice by streptozotocin …
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Investigations of tetraspanin functions using large extracellular loops
… of a specific tetraspanin domain: the large extracellular loop (LEL). Tetraspanins are involved in cellular migration, adhesion, and metastasis, sperm-egg fusion, and viral infectivity. The large extracellular loop domain is the major extracellular domain of tetraspanins and the binding of a …
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FROM MICRONUCLEI TO EMT: MOLECULAR MECHANISMS OF GENOMIC INSTABILITY AND CELLULAR PLASTICITY
Chromosomal instability and its cellular consequences represent critical aspects of cancer progression and genomic instability. The research presented in this thesis encompasses two complementary projects, focusing on distinct yet interconnected molecular pathways. The first project investigates …
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Collagen scaffolds for treatment of penetrating brain injury in a rat model
… one week after injury resulted in a modest cellular infiltrate four weeks later consisting of macrophages, astrocytes, and endothelial cells. The scaffold was able to fill the cavity and provide a substrate for cellular migration into the defect. Incorporation of a Nogo receptor molecule …
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Tissue-Specific Matrix Control of Cell Cohesion and Migration Signaling Complexes
<p>The extracellular matrix (ECM) is a complex, interconnected network of three major constituents: collagens, glycoproteins, and proteoglycans, along with their enzyme modifiers. Within this network and beyond the structural role, each ECM molecule contributes a context-specific signal that …
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Nanoparticle effects on cell migration
… has shown that gold nanoparticles can affect cellular migration, even if outside cells. However, the fundamental of interaction between Au NPs and cells has remained unclear. The most accepted mechanism currently is that by sequestering biomolecules from the environment nanoparticles can …
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Characterizing the role of p21-Activated Kinase 3 (PAK3) in AP-1-induced transformation
… and the role of PAK3 in cJun/AP-1-associated cellular transformation. Our results showed elevated PAK3 expression at both the mRNA and protein level in cJun-over-expressing Rat1a fibroblasts, as well as in transformed human fibroblasts. Elevated PAK3 protein levels were also seen in cervical, …
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Processive Acceleration of Actin Barbed End Assembly by N-WASP
… of the actin cytoskeleton triggers a plethora of cellular processes including cellular migration. Neural Wiskott Aldrich syndrome protein (N-WASP) is involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. N-WASP activated actin polymerization drives …
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Identification of Novel CCR4 Antagonists Through Inhibition of CCL22-Induced Cell Migration
… CCR4 antagonists using an in vitro transmigration assay, focusing on the inhibition of CCL22-mediated migration. RAW 264.7 cell lines, as well as CCR4-transfected HEK293T cells, were used in our studies. Our findings demonstrated increased migration of CCR4+ HEK293T cells towards CCL22, …
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Low-power switched-capacitor amplifier and Sigma-Delta modulator design for integrated biosensor applications
… are believed to play a role in the process of cellular migration during development. Today there is no practical way to measure gradients of neurotransmitters across pieces of tissue in both the spatial and temporal domains. Single electrode systems can be used to determine neurotransmitter …
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The Neurogenic Capacity of Müller Glia and Synaptic Remodeling in the Mammalian Retina: Implications for Regenerative Therapies
… and bipolar cells) showed dendrite retraction, cellular migration, and a loss of post-synaptic elements that increased with disease progression. Surprisingly, the inner retina remained relatively intact even at advanced stages of degeneration. Furthermore, survival of small numbers of cone …
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Enzyme engineering by directed evolution and applications in cellular imaging and proteomic mapping
… individual protein components within the native cellular context. A wide panoply of enzyme-mediated labeling methodologies have been developed that couple the power of enzyme specificity with the functional diversity of small molecules to specifically tag proteins within the crowded heterogeneous …
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