Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"Cellular Microenvironment"”.
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Nanoscale and microscale approaches for engineering the in vitro cellular microenvironment
… microfabrication approaches to manipulate cell microenvironment in culture. To control cell migration and to restrict cell or colony size, cells and proteins were patterned by using molding or printing methods. Poly(ethylene glycol)-based molecules and polysaccharides were used to control …
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Biophysical and biochemical factors in the cellular microenvironment; effects on cell migration and invasion
<p>Cellular migration is a vital process central to many physiological events including development, immune surveillance and wound healing. However, migration and invasion are not unique to normal physiology, they are also key determinants in the progression of disease states such as cancer. Given …
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Investigating the Interplay between Inflammation and Matrix Stiffness: Evaluation of Cell Phenotype and Cytoplasmic Stiffness In Vitro
The cellular microenvironment in vivo consists of both mechanical and chemical signals, which drive cell function and fate. These signals include the composition, architecture, and mechanical properties of the extracellular matrix (ECM), signaling molecules secreted by cells into their …
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COMBINATORIAL DEVELOPMENT OF NANOSTRUCTURED MATERIAL LIBRARIES FOR THE STUDY OF CELL SUBSTRATE INTERACTION
An in vivo cellular microenvironment in which cells are immobilized contribute an essential role in diverse cellular behavior, consisting of cellular morphology, dynamics and eventually cellular fate. Micro and nanofabrication tools widely used to mimic the in vivo surrounding to manipulate …
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Molecular Mechanism of Parvovirus Infection
… our findings promote a novel concept that the cellular microenvironment determines the exclusive tropism of B19V to erythroid progenitor cells, in addition to B19V receptor and co-receptors. Our work provides insights into virus-host interaction during both early and late stages of parvovirus …
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Controlled Intracellular delivery of molecules using Nanoparticle-mediated Photoporation
Intracellular drug delivery has been of interest in recent years after the development of drugs targeting intracellular components. Delivery of exogenous material into cytosol has a variety of applications including cellular studies, therapies and diagnostics. Nanoparticle-mediated photoporation is …
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Engineering three-dimensional lymphatic vasculature on-chip through biochemical and mechanical stimulus
… endothelial cells under a highly controlled microenvironment and isolate the effects of biochemical and biophysical inputs. Under this precise control over local extracellular factors, we studied the angiogenic response of lymphatic endothelial cells to different soluble pro-angiogenic …
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Characterization of molecular dynamic changes in tissue model systems using Fourier transform infrared spectroscopic imaging
… monitor tumor-associated changes in stroma and cellular responses and transformations upon the stimulation from growth factors and mechanical stress in cellular microenvironment. Finally, these issue models are applied to development of new quantitative method to study the dynamic diffusion of …
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Novel Micropatterned Substrate for Investigation of Ovarian Cancer Aggregate Formation and Response to Epigenetic Drug Therapy
… elucidation of processes, one of which is the cellular microenvironment. The current consensus in cancer research is that 3D microenvironments are needed to better mimic in vivo response of tumors to drugs. This study will evaluate the feasibility of using a novel micropatterned substrate that …
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MICROFABRICATION OF TITANIUM DIBORIDE PATTERNED ON SILICON SUBSTRATES FOR MONO- AND CO-CULTURE OF ENDOTHELIAL AND MESENCHYMAL STEM CELLS
… wettability. This BioMEMS device mimics native cellular microenvironment, in terms of topology that provides mechanical support and is expected to regulate the cellular activities such as adhesion, adhesion and viability. Our experiments demonstrated TiB2 as a probable material showing …
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High-throughput microfluidic living cell arrays for spatiotemporal gene expression profiling
The cellular microenvironment is remarkably complex. In the small space near each cell, growth factors are liberated from extracellular matrix, cytokines are secreted from neighboring cells, and hormones arrive from distant organs. These spatially and temporally diverse cues are integrated by …
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Mechanical influence of pressure, topography, and diffusion on cell physiology and function
… of pressure, topography, and diffusion on cellular function and physiology. Pressure is one form of mechanical stimuli that occurs naturally within a cellular microenvironment yet is largely overlooked in day to day cell culture. Here we present two different pressurized incubation chambers …
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Mechanistic Study of DNA Delivery from Self-Assembled Nanolayered Films
… DNA, must overcome both systemic and local cellular barriers. Surfacemediated gene delivery bypasses systemic trafficking obstacles by localizing DNA release within the cellular microenvironment. Local delivery has several advantages including increased efficacy at the target site and …
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Engineered 3D microenvironments to understand and direct liver progenitor and cancer cell fate
The cellular microenvironment encompasses every chemical and physical factor surrounding a cell, including all other cells, cell-cell and cell-extracellular matrix (ECM) signaling interactions and any detectible change in conditions. As the interplay between every component of the microenvironment …
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Predictive Reporter System for Investigating Dose Dependency in Oncogene-Induced Senescence
… conversely have a pro-tumorigenic impact on the cellular microenvironment. Yet, aberrant oncogene activation alone is insufficient for triggering OIS, as studies both in vitro and in vivo have demonstrated that low-dose oncogene cells continue proliferating, in some cases proceeding to full …
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Quantitative Dwi As An Early Imaging Biomarker of The Response to Chemoradiation In Esophageal Cancer
… Quantitative DWI provides a measure of the cellular microenvironment which is impacted by cellularity, extra-cellular volume fraction, structure of the extracellular matrix, and cellular membranes. This work sought to investigate if changes in quantitative DWI may be used as an early imaging …
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Extracellular microenvironment for the regulation of endothelial angiogenic responses
… vessels) along with altered biomechanical and cellular microenvironment. Vascular tissue engineering approaches have been realized as a beneficial means of facilitating the treatments for these diabetic conditions. However, these vascular tissue engineering approaches have had limited success …
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Cell Migration on Opposing Rigidity Protein Gradients: Single Cell and Co-culture Studies
… or chemical. Our goal was to investigate cellular migratory behavior when cells are presented with a choice and have to choose between increasing substrate rigidity or higher protein concentration. We chose to focus on this unique environment since it recapitulates several interfacial …
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Understanding the Cancer Resistance Mechanisms of the Naked Mole-Rat
… processes such as the immune system and cellular microenvironment as key players behind NMR’s cancer resistance. Exploring these new avenues could have profound effect on our understanding of tumour biology.
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DYRK1A-Related Trabecular Defects in Male Ts65Dn Mice Emerge During a Critical Developmental Window
… P30 and P42, suggesting a closer look into cellular mechanisms at P42. Assessment of proliferation of BMSCs, differentiation and activity of osteoblasts showed no significant differences between Ts65Dn and euploid cellular activity, suggesting that the cellular microenvironment has a greater …
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