Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 63 for “"Cellular Membrane"”.
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Mechanism Governing the Cellular Susceptibility to Secretory Phospholipase A2
… attack by sPLA2. Recent studies have focused on membrane properties necessary to induce susceptibility in both artificial and biological membranes. Hydrolysis of phospholipids by sPLA2 requires at least two preliminary steps: first, adsorption of the enzyme to the cellular membrane, and second, …
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Proteomic analysis of Pseudomonas putida F1 during growth on toluene-phenol mixtures
… changes in the phospholipid fatty acids of the cellular membrane. The phospholipid fatty acid composition was found to dramatically change depending on the growth substrate(s). These membrane compositional changes during the biodegradation of the toluene-phenol mixture were used to form the …
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Cofactors in Coronavirus Entry
… important barriers the virus has to cross is the cellular membrane. Enveloped viruses accomplish this task by viral glycoprotein-mediated binding to host cells and fusion of virus and host cell membranes. For the coronaviruses, viral spike (S) proteins execute these cell entry functions. In my …
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BIOCHEMICAL CHARACTERIZATION OF ETHANOL MODIFIED PHOSPHOLIPIDS IN SACCHAROMYCES CEREVISIAE
… (PETH) IS REGARDED AS AN ABNORMAL LIPID IN CELLULAR MEMBRANE, UNIQUELY FORMED FROM PHOSPHATIDYLCHOLINE VIA PHOSPHOLIPASE D-CATALYZED TRANSPHOSPHATIDYLATION IN THE PRESENCE OF ETHANOL. IT HAS A DISTINCTLY DIFFERENT CHEMICAL STRUCTURE COMPARED WITH OTHER PHOSPHOLIPIDS AND MAY PERTURB THE …
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Aquaporin 3 Water Channel Protein Gene Expression in Squalis Acanthias Dogfish Shark
Aquaporins are a family of membrane proteins that provide channels for the rapid movement of water molecules and some small solutes across the cellular membrane. Since the discovery of the first water channel protein, hundreds of homologous proteins have been found in all forms of life and much has …
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Tetraspanin CD9: Contributions to Cancer Cell and Vascular Cell Phenotypes from the Sixth Man
… are cell surface proteins that organize the cell membrane. Cellular membrane organization is a prerequisite for cellular signaling to occur. Deregulation of cellular signaling often precedes the formation of cancer or vascular disease phenotypes. This insinuates the necessity to understand how …
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The missing dimension of cell membrane organization. Study on cubic membrane structure and function
Membranes are of fundamental importance for biological systems. They provide for cellular compartmentalization and control of the internal cell environment. The biophysical properties of the membrane lipids and proteins play a key role in determining the membrane morphology and geometry. Far from …
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One-Step Synthesis of Kanamycin Functionalized Gold Nanoparticles With Potent Antibacterial Activity Against Resistant Bacterial Strains
… their bactericidal action through disrupting the cellular membrane resulting in leakage of cytoplasmic content and death of bacterial cells. Results of this study provide a novel method in the development of antibiotic capped GNPs as potent next-generation antibacterial agents.</p>
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Role of Bcl-2 proteins in neutrophil activation and delayed apoptosis in crystal-induced arthritis
… by the binding of the crystals to the neutrophil cellular membrane, which leads to respiratory burst activity, engulfment of the crystals and release of proteolytic enzymes. Furthermore, we have found that crystals delay the normal “cell death program” or apoptosis, thus allowing for the …
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Membrane fragmentation by a 20-29 fragment of human islet amyloid polypeptide and rat amyloid polypeptide
… aggregates that kill β-cells by disrupting the cellular membrane. In this study we report membrane fragmentation by hIAPP20-29 and the rat version, rIAPP20-29, using solid-state NMR experiments on nanotube arrays of anodic aluminum oxide containing aligned phospholipid membranes.</p> <p>31P NMR …
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Biomolecular interactions and cellular effects of steroidal and metallosupramolecular metallodrugs
… and the ability to reach their possible intracellular targets of certain steroidal metallodrugs and metallosupramolecular cylinders. Chapter 1 surveys the background to the project, surveying different DNA-binding modes, explaining their importance in the anticancer properties of metallodrugs …
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Antimicrobial Nanoparticles: A Green and Novel Approach for Enhancing Bactericidal Efficacy of Commercial Antibiotics
… P. aeruginosa and E. durans by disrupting the cellular membrane resulting in leakage of cytoplasmic content and death of bacterial cell. Our investigation and results provides an additional step in the development of antibiotic capped GNP as potent next generation antibacterial agents.</p>
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Self-assembly of aurfactant-like amphiphilic peptides made of natural amino acids
… One such important problem is the study of membrane proteins, most of which are not amenable to biochemical or structural studies due to their inherent insolubility and instability outside of the natural cellular membrane. Here we describe the development and behavior of a new class of …
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Applying secondary ion mass spectrometry to cellular and model membranes to image component distribution and quantify composition
… (SIMS) returns chemically specific data on membrane component distribution and composition. Of particular interest is a membrane protein’s lipid environment, which may play a role in the protein’s function. Herein, this thesis describes the synthesis of fluorine-functionalized colloidal gold …
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Detection and enrichment of cytochrome P450s using bespoke affinity chromatography and proteomic techniques. Development of chemical immobilisation and novel affinity chromatography methods, with subsequent proteomic analysis, for the characterisation of cytochrome P450s important in cancer research.
Introduction: Cellular membrane proteins, such as the cytochrome P450 enzyme superfamily (P450), have important roles in the physiology of the cell. P450s are important in metabolising endogenous molecules, as well as metabolising xenobiotic substances for detoxification and excretion. P450s are …
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COMPARISON OF E. COLI AND Y. PESTIS LPS TLR4 TIME COURSE ON P388D1 MACROPHAGES USING FLUORESCENT CONJUGATED ANTIBODIES
The innate immune system enables cellular response to infectious agents, and protein interactions are essential for this response. However, the protein interactions involved in cellular response to pathogens are not completely understood. Clarifying the manner in which proteins bind and respond to …
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Cationic Polymers and Polymeric Micelles as Plasmid DNA and CRISPR-Cas9 Ribonucleoprotein Delivery Vehicles
… polymers with liver-targeting ability and cellular membrane-penetration property have been developed and studied for their gene delivery efficiency and cytotoxicity.
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Antiviral activity of 3D8 single chain Fv against RNA virus infection
… activity by electrostatic interaction with cellular membrane and it localizes in cytosol resulting in cell death by cellular rRNA degradation. These result mean that 3D8 scFv would also have potential activity as an intracellular antiviral antibody. Since 3D8 scFv has RNase activity, 3D8 …
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Biochemical changes associated with embryonic and larval development in the American lobster Homarus americanus Milne Edwards
… and sterols were primarily associated with cellular membranes. During tissue catabolism (starvation), P. ethanolamine was catabolized but sterol was conserved. On average, P. ethanolamine fatty acids were the most unsaturated, followed by the fatty acids of P. choline and then …
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Development of an inhalable nanomedicine for lung cancer
… to form nanoparticle (NP) and penetrate cellular membrane for intracellular action. The NPs can also be formulated into inhalable powder using a spray drying method for pulmonary delivery. However, the main challenge is maintaining the stability and functionality of NPs. Herein, RALA …
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