Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"Cellular Injury"”.
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Physical mechanisms of cellular injury in electrical trauma
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering, 1989.
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Mechanisms Underlying Alcohol-Mediated Cellular Injury In Esophageal Keratinocytes
… and in vivo models to study alcohol-mediated cellular injury and cytoprotective mechanisms in esophageal keratinocytes. Here we utilize RNA-Seq to identify dramatic decrease in genes and pathways associated with DNA repair and Mitochondria in alcohol exposed human esophageal keratinocytes. …
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Noxious Cellular Injury Triggers an Oxidative Stress Gene Response
… can induce oxidative stress by elevating intracellular reactive oxygen species (ROS) levels. In this study, we used RNA-seq and qPCR to examine the molecular signature of Human Embryonic Kidney cells (HEK-293T) stimulated with <em>Crotalus atrox </em>(CA) venom. NGS data was assembled and …
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The role of oxygen free radicals in the endotoxic shock induced myocardial dysfunction and cellular injury
… function and contractility and produce tissue injury. We hypothesized that decreases in cardiac function and contractility, and cellular injury during endotoxemia are due to increased levels of OFRs because of increased production and/or decreased destruction and that the agents which prevent …
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The Influence of Dietary Cholesterol on 26-Hydroxycholesterol and the Effect of 26-Hydroxycholesterol on the Intracellular Free Calcium Level
… perturbance, inhibit enzyme activity and cause cellular injury. However, the role of 26-hydroxycholesterol in calcium permeability is still unknown.
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Zinc ion homeostasis in cellular physiology and experimental models of traumatic brain injury
… yet unsolved quest in treating traumatic brain injury (TBI) is the understanding of the secondary cellular injury that contributes to cell death. Whether zinc ions are toxic or protective in TBI is controversial. As an essential human micronutrient, zinc is needed for the structure and function …
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In Vitro Equine Flexor Tendonitis: New Model Development and Therapeutic Investigation
… serum (ACS) in humans for treatment of muscle injury has been shown to speed tissue regeneration. ACS produced from human blood has been shown to contain significantly increased levels of III growth factors that may improve tendon fibril formation and strength. We propose to investigate the …
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The interplay between pro-death and pro-survival signaling pathways converging at mitochondria in myocardial Ischemia/Reperfusion : Apoptosis meets Autophagy
… during myocardial ischemia/reperfusion (I/R) injury, however, whether autophagy functions as a protective or lethal response is unclear. Thus, the main objective of this thesis was to investigate the nature of the relationship between I/R-activated mitochondrial (apoptotic) death pathways and …
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The Effects Of Oxidative Stress On P75ntr Signaling In Dopaminergic Neurons
… (p75NTR) is responsible for implementing cellular death during embryonic development and in response to cellular injury. The receptor has been recognized as a contributor of neurodegeneration in numerous pathological conditions. Cleavage of p75NTR by Tumor Necrosis Factor converting enzyme …
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Effect of Acute Administration of Angiopoietin-1 In Experimental Traumatic Spinal Cord Injury: Magnetic Resonance Imaging and Neurobehavioral Studies
Spinal cord injury (SCI) is a devastating condition that affects people in the prime of their lives. A myriad of vascular events occur after SCI, each of which contributes to the evolving pathology. The primary trauma causes mechanical damage to blood vessels, resulting in hemorrhage. The …
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NLRP3 in Renal Injury and Inflammation
Renal cell injury, death and inflammation are hallmarks of chronic kidney disease (CKD). Unresolved inflammation can chronically damage renal tissue resulting in fibrosis and kidney failure. The Nlrp3 inflammasome has been implicated in the innate immune response to cellular injury and represents a …
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Dry deposition of sulfate and nitrate to soybeans and corn
… such as reduction of cuticular integrity, cellular injury and death, enhanced leaching of primary and secondary metabolites, and changes in pathogen infection efficiency.
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Divergent Roles of PI3K and Akt in Rapamycin-induced Cardioprotection against Ischemia-Reperfusion Injury
… new drugs to protect the heart against cellular damage caused by ischemia-reperfusion injury (I-R injury). Rapamycin is one such drug that has been shown to protect the heart against ischemia-induced cellular injury. Rapamycin(sirolimus) inhibits protein synthesis through inhibition of …
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A Novel Role for and Potential Therapeutic Targeting of Heme Oxygenase-1 in HIV Neuropathogenesis
… for limiting oxidative stress, inflammation, and cellular injury within the central nervous system (CNS) and other tissues. Our analysis of HO-1 expression in the brain prefrontal cortex from HIV-infected individuals demonstrated a significant HO-1 protein deficiency, even in HIV-infected subjects …
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The Rational Design and Use of Novel Small-Molecule Ice Recrystallization Inhibitors for the Cryopreservation of Hematopoietic Stem Cells and Red Blood Cells
… has been an increase in the development of new cellular therapies used for the treatment of various conditions. Thus, the rapid development of therapies requiring transfusion and transplantation of cells has resulted in a need to preserve these cellular therapy products. Cryopreservation is the …
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The Physiological and Morphological Responses of the Bladder Urothelium to Differential Injury
… showcases a rapid ability to regenerate after injury.</p><p>Knowledge of the contribution of bladder injury to nociception: pain) is currently lacking. To increase our understanding of how various injuries, which target different layers of the bladder, affect pain response in mice we used a UTI …
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Membrane Stabilizing Copolymer Poloxamer 188 in Preclinical Models of Acute Myocardial Infarction Reperfusion
… shock and cardiac arrest remain very high. Cellular injury after acute myocardial infarction occurs in two stages- ischemic injury, which occurs when there is a myocardial oxygen supply-demand mismatch, and reperfusion injury, which occurs with the sudden unrestrained return of blood to the …
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Effects of connexin modulators in animal models of retinal degeneration: delivery and treatment efficacy
… docked together forming gap junctions for intercellular communication. However, there is undocking of hemichannels and abnormal opening during inflammation and oxidative stress leading to a series of events that result in vascular leakage, further inflammation and cell death. Connexin43 mimetic …
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Investigation of the proteins SPARC and HMGB1 in chronic airways disease
The matricellular protein, secreted protein acidic and rich in cysteine (SPARC), mediates the interaction between cells and their surrounding extracellular matrix (ECM) but does not contribute structurally to the matrix. It regulates basic cellular functions such as cell adhesion and proliferation, …
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Cardiomyocyte-Specific Deficiency of Ketone Body Metabolism Promotes Accelerated Pathological Remodeling
… significant hepatic steatosis, inflammation, and cellular injury. These preliminary studies thus necessitated the development of improved ketogenic diets that promote increased ketone body circulation in the absence of extraneous pathologies, which I found to be possible through the repletion of …
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