Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Cellular Energy Metabolism"”.
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A Role for the HSV Tegument Protein pUL16 in Modulating Cellular Energy Metabolism during HSV-2 Infection
… the influence of pUL16 on host cell energy metabolism by quantifying parameters of mitochondrial morphology, oxidative phosphorylation, glycolysis and ATP metabolism, in mock, HSV-2 WT and HSV-2 pUL16 null mutant (Δ16), infected human keratinocytes (HaCaT). Mitochondria in WT infected …
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Chronic low-level Pb exposure during development alters proteins involved in energy metabolism in auditory neurons of the brainstem
… even though hearing remains normal. Pb disrupts cellular energy metabolism and efficient energy production is crucial for auditory neurons to maintain their high rates of synaptic activity. The voltage dependent ion channel (VDAC) is an ion channel involved in the regulation of mitochondrial …
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Chronic low-level Pb exposure during development alters proteins involved in energy metabolism in auditory neurons of the brainstem
… even though hearing remains normal. Pb disrupts cellular energy metabolism and efficient energy production is crucial for auditory neurons to maintain their high rates of synaptic activity. The voltage dependent ion channel (VDAC) is an ion channel involved in the regulation of mitochondrial …
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Oscillations in microvascular flow : their relationship to tissue oxygenation, cellular metabolic function and their diagnostic potential for detecting skin melanoma - clinical, experimental and theoretical investigations
… of cancer, intermittent hypoxia and altered cellular energy metabolism. The former is explored through the analysis of blood flow and oxygenation data recorded during dry static apnoea, whilst the latter is modelled using coupled phase oscillators.
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Investigating the effects of Wnt/β-catenin Signalling on Melanoma Cell Metabolism and Mitochondrial Dynamics
… that results in the stabilisation of an intracellular signalling molecule called β-catenin. In melanoma cells, Wnt/β-catenin signalling has been implicated as a key regulator of cellular invasion and metastasis. Using both transient and stable enhancement of Wnt/β-catenin signalling, I have …
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The assembly of mitochondrial Complex I. A product of nuclear-mitochondrial synergy.
Contains fulltext : 30935_asseofmic.pdf (Publisher’s version ) (Open Access)
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Identification of Substrates and Pathways Regulated by PAS Kinase
… screen for putative PASK substrates from cellular extracts uncovered five polypeptides phosphorylated in a PASK-dependent manner. Two of the substrates identified are known translation factors and a third is an RNA-binding protein that was also found to be a high copy suppressor of the …
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PHYTOCHEMICAL AND SYNTHETIC INVESTIGATIONAL COMPOUNDS AS MODULATORS OF CYTOMETABOLIC AND CYTOSKELETAL DYNAMICS FOR PRE-CLINICAL TARGETING OF PROSTATE CANCER
… and epigenetic factors involving multiple cellular signaling networks are implicated in the initiation, progression, and metastasis of this disease. Therapeutic drug resistance and hormone-sensitive and/or refractory metastases present a major stumbling block in disease management. However, …
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The relationship between glucose metabolism byproduct, D-lactate, and vascular endothelial cell dysfunction and possible role in diabetes
… (20 mM) and MG (5 µM) combined cause changes in cellular energy metabolism, creatine (Cr) and high-energy phosphate substrates (CrP, ATP, ADP, AMP) were quantified using HPLC and no changes were observed. We further measured ROS production in HUV-EC-C treated with 0.06-2 mM DLA alone or 0.2 mM …
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From Protein Structure to Clinical Strategy: An In silico Investigation of Mitochondrial DNA Mutations in Type 2 Diabetes and Degenerative Disc Disease for Targeted Nutritional Interventions
… non-coding RNAs, plays a central role in cellular bioenergetics, however, the structural consequences of pathogenic mitochondrial single nucleotide variants (SNVs) remain incompletely characterized, especially in South African populations that are substantially underrepresented in global …
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Mechanism of Action of Nicotinamide Phosphoribosyltransferase Mediated Signaling in Oxidative Stress
… (Nampt) is an enzyme critical for cellular energy metabolism, and it also functions as a proinflammatory cytokine and growth factor with neuroprotective properties and in these contexts is referred to as Pre-B-Cell Colony Enhancing Factor (PBEF) and Visfatin, respectively. …
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Anoxia tolerant hepatocytes : a model system for the study of metabolic and channel arrest
… making a comprehensive understanding of the intracellular anoxic defense mechanisms difficult to obtain. A cell level system that responses to anoxia in a fashion similar to that of the anoxia-tolerant animal from which it was obtained would be invaluable. Described here is a method for the …
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Lipoic acid metabolism in Leishmania major
… hosts, and therefore must be able to adapt their energy metabolism to the available carbon and nitrogen sources. Lipoic acid (LA) is a multifaceted molecule, and plays an important role as a water- and fat-soluble antioxidant. LA is also an essential cofactor of the alpha-ketoacid dehydrogenase …
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Conception et réalisation d'un photobioréacteur adapté à l'étude de la production d'hydrogène chez les micro-algues. Application à l'étude de l'influence d'une NAD(P)H déshydrogénase-plastoquinone-réductase chloroplastique de type II sur le potentiel de photoproduction d'hydrogène chez Chlamydomonas reinhardtii.
… on the set of biochemical reactions that define cellular energy metabolism. In Chlamydomonas, H2 photobioproduction is ensured by two enzymes (Hyda1 and Hyda2). These two enzymes are located in the chloroplast stroma, they catalyze the reaction of hydrogen production (Fig. 1). The electrons …