Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 94 for “"Cellular Differentiation"”.
-
Epigenetic determinants of cellular differentiation, transcriptional reprogramming, and human disease
Much of the diversity we observe in cellular and organismal phenotypes can be attributed to epigenetic and genetic variation. DNA provides the instructions for life, while epigenetic modifications regulate which parts of the genetic information contained in DNA can be read out in a given cell and …
-
Inflammation-associated gene regulation in primary astrocytes, glial tumors and cellular differentiation
… mechanisms of this process in an in vitro differentiation model. We turn our attention to the NFI family of transcription factors since they have recently emerged as novel regulators of the development of vertebral neocortex. We developed a stem cell-neural progenitor-astrocyte …
-
Assessing the transition state model for cellular differentiation in vivo: a case study of zebrafish neuromesodermal progenitors
During the process of cellular differentiation, stem or progenitor cells undergo a sequence of cell state changes before acquiring the characteristics of their destination fate. The transition state model proposes that a transient window of increased gene expression stochasticity and diversity …
-
Contributions to Statistical Problems Related to Microarray Data
… expressed genes. Second, we study the cellular differentiation process and proposed a statistical test for detecting early differentiation genes. Third, we further proposed a model-based method for the cellular differentiation problem.
-
Morphogenesis and Growth Driven by Selection of Dynamical Properties
… to the problem, abstracting the organism as a cellular automaton. Such systems are discrete digital models of real-world environments, making them more accessible and easier to study then their physical world counterparts. In such simplified synthetic models, we find that the structure of the …
-
The Neurotrophic Influence on Craniofacial Development Subsequent to in Utero Unilateral Transection of the Trigeminal(V) Nerve
… of the trigeminal(V) nerve in the regulation of cellular differentiation, tissue morphogenesis, subsequent development and growth, and maintenance of the craniofacial complex. This research is believed to be the first time that such a procedure has been attempted on a mammalian fetus. Each animal …
-
Regulation of Endothelial Nitric Oxide Synthase in Pulmonary Myofibroblasts
… implicated in the fibroproliferation and extra cellular matrix deposition commonly seen in IPF. The nitric oxide (NO) signaling pathway is implicated in protomyofibroblast to myofibroblast transition and regulation. Previous work has shown that in pulmonary myofibroblasts, endothelial nitric …
-
Machine Aided Biological Discovery and Design
… and apply computational approaches for modeling cellular differentiation trajectories, identifying non-specific antibodies, and designing diverse libraries of biological sequences that reflect desired objectives. First, we introduce a generative machine learning model for inferring cellular …
-
Genetic Control of Eye Development, a Case Study Focused on the Murine Mutation Belly Spot and Tail (BST)
… that regulate the timing and location of cellular differentiation. One approach to understanding this network of genes and their interaction is to focus on mutations, spontaneous or induced, that predictably disrupt the proper function of such networks, and by examining the effect of such …
-
Comparative Histology and Histochemistry of the Male Genital Accessory Glands of <em>Dermacentor variabilis</em> (Say and <em>Argas radiatus</em> (Railliet)
… spongy and/or granular lobes. The glands lack cellular differentiation in immatures, but have four distinct cell types present in adults. Both species also possess apocrine, holocrine, and merocrine secretory mechanisms. Secretions contain acid polysaccharides, mucin, glycogen, basic protein, …
-
Mathematical modelling of autophagy pathway.
… plays an important role in physiological cellular processes, is a survival mechanism under external stress and is also connected with cancer and neurodegenerative diseases [Cuervo, 2004; Kondo et al., 2005; Levine, 2007; Pan et al., 2008]. Autophagy is the pathway for degradation of …
-
Co-targeting among microRNAs is widespread and enriched in the brain
… roles in diverse developmental processes and cellular differentiation. Distinct miRNAs have hundreds to thousands of conserved binding sites in mRNAs, but typically exert only modest repression on a single site. Co-targeting of individual mRNAs by multiple different miRNAs could be commonly …
-
INTEGRATIVE GENOMICS UNVEILS TRANSCRIPTION FACTOR ROLES IN CELLULAR FATEAND SPATIALLY RESOLVED TRIPLE-NEGATIVE BREAST CANCER IMMUNITY CAPACITY
… investigates transcription factors (TFs) in cellular differentiation, addressing the inefficiency in current cellular conversion strategies due to the complex TF regulatory landscape. We developed a comprehensive screening of 130 developmental TFs, comparing their dosages in a single …
-
Patterning the Drosophila Embryonic Central Nervous System: Establishing Neuroblast-Specific Gene Expression and Identity
… diversity. Studying the mechanisms of neuroblast differentiation will help to understand cellular differentiation at a broad level. In this thesis, I present new information on how neuroectoderm position translates into neuroblast-specific gene expression. Along the antero-posterior axis, a group …
-
Function of a C-rich region in the transcriptional regulation of the glycogen phosphorylase-2 gene in Dictyostelium discoideum
The cellular slime mold Dictyostelium discoideum is a simple eukaryote that has been used as a model organism for the investigation of eukaryotic cell signaling, regulation of gene expression, and development. Transcription of the gp-2 gene is induced during development and is regulated by …
-
Evidence that ARNT plays a role in the regulation of the immunoglobulin heavy chain enhancer and identification of a putative ARNT ligand
… a multitude of developmental processes including cellular differentiation, cellular proliferation and xenobiotic metabolism. Among the members of the bHLH protein family are the products of the Pan gene Pan-1, Pan-2 and ITF -1. Pan proteins have been demonstrated to be required for proper B cell …
-
On the average generation of a population
… of cells is helpful in understanding complex cellular differentiation processes, identifying carcinogenic cellular activities, and quantifying the ageing of the immune system. Different techniques based on both direct observations and indirect inference have been proposed, with benefits and …
-
Understanding tumor cell plasticity in spatial transcriptomics with graph attention networks and walk-based pseudotime analysis
… biologically relevant neighborhoods and maps differentiation pathways. When applied to pancreatic ductal adenocarcinoma (PDAC), distinct, conserved neighborhoods within the tissue, including diverse immune and cancer clusters. By estimating a differentiation path from epithelial to …
-
Living Together: A Capability Approach to Spatially Segregated Areas of Bogota
… of fragmentation are evolving towards a more ‘cellular’ differentiation between rich and poor –urban segregation which changes in terms of scale: from macro (neighbourhoods) to micro scales (blocks, streets). Urban segregation has been associated as a barrier for disadvantaged communities, …
-
Towards Identifying Cis and Trans Regulators of Expression of Xylem Cysteine Protease 1 (XCP1) in Arabidopsis
… elements. Understanding tracheary element differentiation and maturation is of scientific and commercial importance as it may lead to broad understanding of cellular differentiation processes as well as ways to increase both the quality and quantity of wood produced by economically …
Page 1 of 5