Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 22 for “"Cellular Cytotoxicity"”.
-
Age-Dependency of Swine Antibody-Dependent Cellular Cytotoxicity Against Pseudorabies Virus-Infected Cells
… immunity against PRV infections involves both cellular and humoral immune responses. Antibody-dependent cellular cytotoxicity (ADCC) which involves both cell functions and antibodies might prove to be important in protection against PRV. Therefore, the age differences and age development of …
-
Comparing high-throughput methods to measure antibody dependent cellular cytotoxicity during HIV infection
… against HIV are complex and involve both cellular and humoral immunity. Based on the recent finding that the best correlate of protection against the first protective prophylactic RV144 vaccine were HIV-specific antibody responses, including those mediating natural killer (NK) cell …
-
Evaluation of children with haemophagocytic lymphohistiocytosis (HLH) at Red Cross War Memorial Children's Hospital 1991-2010
… production of cytokines, alongside reduced cellular cytotoxicity as a result of reduced or absent NKC function.
-
Humoral immune response to melanoma: discovery and evaluation of anti-melanoma antibodies
… were conducted. Using a live cell imaging cytotoxicity assay, this patient-derived melanoma-specific antibody was observed to kill melanoma cells via antibody-mediated cellular cytotoxicity. Additionally, two engineered monoclonal antibodies recognizing a melanoma associated antigen were …
-
Design, Synthesis And Biological Evaluation Of Small Molecules That Inhibit Hiv-1 Entry And Sensitize Hiv-1 Infected Cells To Immune Responses
… of HIV-1 infected cells to antibody-dependent cellular cytotoxicity (ADCC). The first part of my thesis describes the development of a late-stage derivatization strategy for the synthesis of 1,2,5,7-tetrasubstituted aminoindane small molecule CD4mc and the corresponding biological evaluation. …
-
JAG1 Blockade With oHSV Polarizes Macrophages to Create a Unique Vulnerability for Cetuximab-Mediated Senolysis of Glioma Cells
… chemokines and DAMPs such as IL-1β and extracellular ATP. RNA sequencing of murine macrophages co-cultured with infected human tumor cells showed enrichment of chemotactic and pro-inflammatory pathways as well as increased Fc receptor activation following OncoD-0J1 infection. Single-cell RNA …
-
Functional Modeling of Genes Upregulated in Chronic Myeloid Leukemia
… IL1RAP antibody enabled antibody-dependent cellular cytotoxicity (ADCC) of CD34+CD38- CML cells in vitro. In Article III, the function of IL1RAP in normal hematopoeisis and in CML was investigated. Mice lacking Il1rap displayed lower myeloid steady-state cell counts. Overexpression of IL1RAP …
-
A Novel Syndecan-1 Targeted Therapeutic Antibody Inhibits Macropinocytosis and Induces Anti-Tumor Immunity in Pancreatic Cancer
… salvage as well as induces antibody-dependent cellular cytotoxicity (ADCC) to eliminate PDAC cells. Notably, <em>in vivo</em>, our anti-SDC1 mAb exhibited synergistic anti-tumor effects in combination with first-line chemotherapy, KRAS* inhibitors, and immunotherapies, resulting in robust tumor …
-
Development and Characterization of A Bi-Specific Antibody Targeting Hla-A2/Pr1
… eliminates AML xenografts by antibody-dependent cellular cytotoxicity (ADCC) following repeat dosing. To improve the potency of h8F4, we have developed a bi-specific T cell-engaging antibody that targets PR1/HLA-A2 on leukemia and CD3 on neighboring T cells. Here we demonstrate successful …
-
Host Entry Factors for Human Coronaviruses
… distinct cell surface microdomain from the host cellular receptor. However, viral binding triggers the relocalization of the protease to the same microdomain as the receptor, possibly allowing it to cleave the glycoprotein immediately after receptor binding.</p><p>While proteases are a key host …
-
Chimeric ANTI-CD19 Monoclonal Antibodies for the Treatment of Precursor B Cell Acute Lymphoblastic Leukemia
… effective at mediating antibody dependent cellular cytotoxicity (ADCC) with mouse effector cells. The anti-tumor activities of all three MAbs were identical in SCID mice xenografted with human B cell tumors. However, the chimeric tetravalent MAb has a higher binding affinity and a longer …
-
The Role of Vav-1, Vav-2 and Lsc in NK T cell development and NK cell cytotoxicity
… required for natural and antibody dependent cellular cytotoxicity (ADCC) of human NK cells. In this study, I show that Vav-1 is also expressed in murine NK cells. Vav-1-/- mice had normal numbers of splenic NK cells, and these displayed a similar expression profile of NK cell receptors as …
-
Excessive iron accumulation mediated oxidative stress and β-cell dysfunction via perturbations of insulin secretion in MIN6 cells
… of T2DM. Reactive oxygen species (ROS) mediated cellular oxidative damage has been implicated in cellular dysfunction in various organs and disease states. Exposure to high level of glucose during hyperglycaemia has been co-related to ROS generation and oxidative stress in β-cells. In the initial …
-
Importance of specific NK cell subsets for antitumor immunity in HPV+ cancers
… an NK receptor important for Antibody Dependent Cellular Cytotoxicity (ADCC). In HPV+ head and neck patients, post-SOC, the circulating pre-mNK cells exhibited significant increases in GrnzB and CD16, indicating elevated cytotoxic potential after treatment. In cervical cancer patients, we …
-
Preparation and characterization of multifunctional chitosan microparticles for lung delivery
… retained in the chitosan microparticles. The cellular uptake studies display similar cellular uptake behavior for drug solutions treatments and gemcitabine iron oxide microparticle treatments. However the cellular cytotoxicity observed was higher in the gemcitabine iron oxide microparticle …
-
DESIGN, SYNTHESIS, AND OPTIMIZATION OF SMALL-MOLECULE CD4 MIMETICS AS HIV-1 ENTRY INHIBITORS AND SYNTHETIC EFFORTS TOWARD THE TOTAL SYNTHESIS OF NAHUOIC ACID Cii
… sensitizing infected cells to antibody-dependent cellular cytotoxicity (ADCC). This work describes the rational design, synthesis, and evaluation of novel CD4mc analogs aimed at improving antiviral potency, breadth, and physicochemical properties. Quaternary analogs were synthesized to enable …
-
Discerning the Mechanism of Gamma Delta T Cell-Mediated Damage in Multiple Sclerosis: the Potential Role of Antibodies in Disease Pathogenesis
… shown to exert cytolysis via antibody-dependent cellular cytotoxicity (ADCC). We postulated that if there were also relevant and detectable antibodies in MS patients that might engage these FcR-bearing γδ T-cells then this might be a purported mechanism of neuro-axonal injury. A search for …
-
Methods in Total Synthesis: Development of a 2nd-Generation Synthesis of CJF-III-288, and Synthetic Efforts Towards the Total Synthesis of Sequoiamonascin A
… HIV+ plasma mediated antibody-dependent cellular cytotoxicity (ADCC). These results justified the development of a more efficient synthesis of CJF-III-288 to access larger quantities of the compound to assess CJF-III-288’s ability to sensitize HIV-1 infected cells to ADCC in animal …
-
Human macrophage model for selective evaluation of CD8⁺ and γδ⁺ cytotoxic T cell function in tuberculosis
… Mycobacterium tuberculosis, control intracellular mycobacterial growth, and present mycobacterial antigens to human HLA class I-matched cytotoxic T lymphocytes (CTLs). Differentiation of U937 cells usmg IFN-γ, 1,25-(OH)₂ vitamin D₃, or PMA significantly enhanced their ability to …
-
The impact of neutralizing antibody and ADCC responses on HIV-1 envelope evolution in early infection
… vaccine studies suggest antibody-dependent cellular cytotoxicity (ADCC) responses, which target virus-infected cells, may also be protective. This thesis uses deep sequencing, together with immune assays, to characterise HIV-1 Envelope evolution associated with both nAb and ADCC responses in …
Page 1 of 2