Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"CellProfiler"”.
-
CellVisualizer : exploring hierarchical, multi-dimensional data with applications to high-throughput microscopy
… by high-throughput microscopy and processed by CellProfiler, an open-source system jointly developed by researchers at MIT CSAIL and the White-head Institute. A typical high-throughput microscopy experiment produces thousands of images, with thousands of objects in each image. CellProfiler then …
-
Life extension of structural components via an improved nondestructive testing methodology
… industrially. An image analysis program called Cellprofiler was used to optimize the threshold correction factor for selected results. The Cellprofiler output was analyzed in conjunction with POD software, and the integration of digitally advanced NDT techniques with image analysis software …
-
Using Heterogeneous Information Sources for Understanding and Predicting Biological Effects of Compounds
… cell morphology information (in the form of CellProfiler features) from a Cell Painting assay and chemical structure information in the form of Extended Connectivity Fingerprints. The comparison revealed that there were targets better predicted by cell morphology information such as the …
-
Making computer vision Methods accessible for cell classification
… can be quantified with spectral analysis. Next, CellProfiler Analyst, an updated software application for interactive machine learning classification and feature analysis is described along with its use for classifying imaging flow cytometry data. Further software related advances include the …
-
Investigation of Microbiome Metabolites and Mitochondrial Function in a model of Non-Alcoholic Fatty Liver Disease
… assessed by BODIPY™ staining and quantified by CellProfiler software. To gain insight into HepaRG mitochondrial respiration, we measured a number of bioenergetic parameters with the Seahorse extracellular flux analyser in control cells and cells exposed to PAA (100 µM and 200 µM) or TMAO (20 µM, …
-
Investigating the Biomechanical and Electrophysiological Responses of Astrocytes to Mechanical Trauma
… Activity Index (AAI), was developed using a CellProfiler-based pipeline. The AAI quantifies fluctuations in total fluorescence over time to assess population-wide calcium activity, providing an alternative when reliable cell-specific segmentation was not feasible. For all other assays, nuclei …
-
Using Cell Painting and Chemical Data for Small-molecule Bioactivity and Toxicity Prediction
… features derived using software such as CellProfiler and to generate hypotheses for experimental validation. In summary, our work demonstrates the potential of combining chemical and biological data for enhanced prediction of drug safety endpoints with practical implications in drug …
-
Phenotypic screening and AI uncovers modulators of YAP and TAZ activity in glioblastoma
… and preclinical stage compounds. Using a bespoke CellProfiler image analysis pipeline and a combination of Hit Selection using a Neural Network classifier (StratoMiner HC), 32 hit compounds were prioritised for testing in secondary screening assays before further evaluation in multiple functional …
-
Effects of galectins and antibodies in HIV infection; Novel Assays
The high variability of the HIV envelope glycoproteins (Env), and their heavy glycan coating, contributes to the limited host immune control. Still, broadly neutralizing antibodies (bnAbs) are found in some chronically infected HIV-infected individuals, which has spurred the research on …