Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Cell-substrate interactions"”.
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Effect of Cell-Substrate Interactions on Epithelial Cell Mechanics
Cell-substrate interactions play a key role in the regulation of epithelial cell mechanics. Through a series of studies, we demonstrate how substrate interactions impact both the response to an oncogene and the cellular contractility and organization of a monolayer. We first examine the effects of …
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Biomolecularly and mechanically instructive materials for guiding cell-substrate interactions
… advance our understanding and ability to guide cell fate and function. Benzophenone (BP) photolithography is uniquely suited to generating chemically and mechanically tailored materials because of its molecularly general and spatially modulated characteristics. Here, we describe the application …
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Nanoscale and microscale approaches for engineering the in vitro cellular microenvironment
… and microfabrication approaches to manipulate cell microenvironment in culture. To control cell migration and to restrict cell or colony size, cells and proteins were patterned by using molding or printing methods. Poly(ethylene glycol)-based molecules and polysaccharides were used to control …
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Development of a direct photochemical method for the generation of biomolecular interfaces for applications in leukocyte biology
… photochemical method for creating biointerface substrates presenting single- and multi-component biomolecular patterns and gradients. In our approach, the generation of a light density gradient across a photoactive benzophenone monolayer on glass results in covalent attachment of solution-phase …
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Biomimetica per l'ingegneria tissutale dell'osso
… be represented by tissue engineering that use cells (and/or their products) and innovative biomaterials to perform bone substitutes biologically active as an alternative to artificial devices. In the last years, there was a wide improvement in biology on stem cells potential research and in …
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Structural Stiffness Gradient along a Single Nanofiber and Associated Single Cell Response
Cell-substrate interactions are important to study for development of accurate in vitro research platforms. Recently it has been demonstrated that physical microenvironment of cells directly affects cellular motility and cytoskeletal arrangement. Specifically, previous studies have explored the …
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Biomimetic Surface Coatings from Modular Amphiphilic Proteins
… of biofunctional scaffolds to precisely regulate cell behavior and tissue growth is of significance in regenerative medicine. Protein-based biomaterials are attractive candidates for functionalization of scaffold surfaces since the ability to precisely control protein sequence and structure allows …
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An investigation into the characteristics and potential therapeutic application of human neural progenitor cell-derived astrocytes in experimental spinal cord injury
… axon-growth promoting (e.g. migration of Schwann cells into the lesion site and the local presentation of growth promoting factors and extracellular matrix proteins) and axonal growth inhibitory/repulsive molecules (e.g. myelin-associated proteins, the presence of a physical barrier presented by …
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Effect of low temperature on Sauvignon blanc fermentation by Saccharomyces cerevisiae
… Flo1p may increase Vmax through FLO8-independent cell-substrate interactions induced during stressful conditions such as fermentation.
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Non-Covalent Interactions in the Design and Performance of Macromolecules for Biological Technologies
Supramolecular, or non-covalent, interactions remain a hallmark of biological systems, dictating biologic activity from the structure of DNA to protein folding and cell-substrate interactions. Harnessing the power of supramolecular interactions commonly experienced in biological systems provides …
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The influence of nanotopographical structures on osteoblast adhesion formation and the functional response of mesenchymal stem cell populations
… of these devices in an attempt to regulate cellular adhesion, a process fundamental in the initiation of osteoinduction and osteogenesis. Advances in fabrication techniques have evolved the field of surface modification and, in particular, nanotechnology has allowed the development of …
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Identification of Cell Biomechanical Signatures Using Three Dimensional Isotropic Microstructures
… biology (BioMEMS) enables precise control of the cellular microenvironments and offers high throughput systems. The focus of this research was to develop three dimensional (3-D) isotropic microstructures for comprehensive analysis on cell-substrate interactions. The aim was to investigate whether …
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Synthesis and Microscopic Characterizations of Virus Nanoparticle-Based Composite Materials
… methods have been studied to fabricate extracellular matrix (ECM) mimic substrates, which are well known to support for cellular adhesion, growth, and differentiation. The fibrous network of ECM structures can be mimetic by an electrospinning method. Using this technique, the functionalized …
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Investigation of cell-based therapies employing microcapsules and microspheres: encapsulation and controlled release
Microencapsulation of therapeutic cells has emerged as a major modality to treat a wide range of diseases through protecting the encapsulated cells. However, in spite of numerous refinements in cell encapsulation during the past decades, the strategy still has not met the requirements for practical …
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Emergent behavior of cells on microfabricated soft polymeric substrates
In recent years, cell based bio-actuators like cardiomyocytes and skeletal muscle cells have emerged as popular choices for powering biological machines consisting of soft polymeric scaffolds at the micro and macro scales. This is owing to their unique ability to generate spontaneous, synchronous …