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Showing 1 to 20 of 51 for “"Cell-penetrating peptides"”.
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Smart Cell-Penetrating Peptides. Strategies to regulate cellular uptake
Contains fulltext : 157591.pdf (Publisher’s version ) (Open Access)
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Novel Cell Penetrating Peptides Effect Endosomal Escape and Deliver Protein Cargos into Living Cells
<p>Over the last decade a number of peptides that are rapidly internalized by mammalian cells have been discovered or designed. Cell-penetrating peptides (CPPs) are capable of mediating penetration of the plasma membrane, allowing delivery of macromolecular cargoes to the cell interior. We have …
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Hybrid Cyclic-Linear Cell-Penetrating Peptides Containing Alternative Positive and Hydrophobic Residues as Molecular Transporters
<p>The cell membrane properties create a significant obstacle in intracellular delivery of cell-impermeable and negatively charged molecules. Amphiphilic cyclic peptides containing alternative arginine and tryptophan such as [WR]<sub>5</sub> have been shown to enhance the transport of cargo …
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More ins than outs for tumour cell targeting: Combining molecular imaging probes and cell-penetrating peptides
Contains fulltext : 241556.pdf (Publisher’s version ) (Open Access)
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A New Approach to Drug Delivery: Non- Peptidic, High Load Macrocyclic Alternatives to Cell Penetrating Peptides
… functionalising calixarenes. The phenomenon of cell penetration is of interest where a molecule has an intracellular target, for example gene therapy, delivery of cytotoxic agents or cellular imaging. Chapter 2 introduces the mechanisms of cell uptake and the design and applications of cell …
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Cyclic and Linear Peptides Containing Tryptophan and Arginine Residues as Cell-Penetrating Peptides and Antifungal Agents
… a novel group of linear and cyclic amphiphilic peptides containing different sequences of arginine (R) and tryptophan (W) residues. The peptides included a class of cyclic peptides, [R3W3]2, [R3WRW]2, [RWW]4, [WRR]4, [RWRW3]2, and the corresponding linear peptides, (R3WRW)2, (RWW)4, (WRR)4, …
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Amphiphilic Cyclic Cell-Penetrating Peptides Containing Tryptophan and Arginine as Anticancer Agents and Drug Delivery System
<p>Amphiphilic cyclic cell-penetrating peptides composed of an increasing number of alternative tryptophan (W) and arginine (R) were synthesized and evaluated as a molecular transporter and for their ability to deliver doxorubicin (Dox) and large molecular weight molecules, such as siRNA and …
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Synthesis, Characterization, and Evaluation of Amphiphilic Cell-Penetrating Peptides as siRNA Delivery Tools for Cancer Therapy
… the last two decades, it has been found that cell-penetrating peptide (CPP)-based delivery systems show enhanced uptake of siRNA. This dissertation aimed to investigate fatty acyl cell-penetrating peptides (CPPs) as siRNA delivery tools. We hypothesized that conjugation of hydrophobic …
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Amphiphilic Cell-Penetrating Peptides Containing Natural and Unnatural Amino Acids as Drug Delivery Tools and Antimicrobial Agents
<p>Cell-penetrating peptides containing arginine as positively charged residues and tryptophan or diphenylalanine as hydrophobic residues were synthesized. The synthesis was accomplished through the Fmoc solid-phase peptide synthesis in the presence of HBTU and DIPEA. The side-chain protected …
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Structural Transitions in Self-Assembled Lipid Systems Driven by Induced Curvature: From Cell -Penetrating Peptides to Programmable Vesicles
… examined the interactions of other arginine rich cell-penetrating peptides, including Antp and oligoarginine, with model cell membranes, and find that the transduction activity correlates with induction of negative Gaussian curvature. The negative Gaussian membrane curvature is broadly enabling …
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Structural transitions in self-assembled lipid systems driven by induced curvature: from cell-penetrating peptides to programmable vesicles
Arginine rich cell-penetrating peptides are short cationic peptides capable of traversing the plasma membranes of eukaryotic cells. While successful intracellular delivery of many biologically active macromolecules has been accomplished using these peptides, their mechanisms of cell entry are still …
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The journey of cell-penetrating peptides into cells - Studies on interactions with components of the plasma membrane and their impact on internalization
Contains fulltext : 140172.pdf (Publisher’s version ) (Open Access)
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Design and Sythesis of Conjugages of Amphiphilic Cell-Penetrating Peptides Containing Anticancer Drug and Ligand for Extra Cellular Matrix Biomarker to Provide Efficient Tumor-Targeting
… of anticancer drugs with cancer- targeting peptides using established biomarkers of cancer such as the integrin receptor and extra-domain of fibronectin (EDB-FN) at the extracellular matrix. In the first studies, a series of targeting peptides targeting EDB-FN were synthesized and conjugated …
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Charge and membrane curvature induced transitions in biomolecular systems: from actin bundles to cell-penetrating peptides to Bcl-2 cell death regulation in the mitochondria
Item reinstated by Sarah Shreeves (sshreeve@illinois.edu) on 2014-02-01T11:00:26Z Item was in collections: Graduate Theses and Dissertations at Illinois (ID: 204) Dissertations and Theses - Physics (ID: 445) No. of bitstreams: 2 Lai_GheeHwee.pdf: 9845710 bytes, checksum: …
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Pharmacologically Replicating Metabolic Protective Mechanisms of Hypothermia in Cardiac Arrest
… toxicity of small molecule inhibitors, two cell-penetrating peptides were developed—TAT-PTEN9c and TAT-PHLPP9c. In the present study, we investigate how hypothermia influences myocardial signaling and metabolism in the setting of ischemia/reperfusion, and then attempt to pharmacologically …
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Design, Synthesis And Characterization Of Lipidated Pna-Peptide Conjugates As Potentialtherapeutic And Diagnostic Reagents
… lipids or phospholipid molecules and hydrophilic cell penetrating peptides to the N and C terminus of PNAs, and studied their physical and biological properties. After solid-phase automated synthesis, PNA-CPPs: TAT/Arg9) were coupled with lipids or phospholipids before cleavage from the support …
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