Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Cell-penetrating activity"”.
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Functional stability of a nucleic acid-hydrolyzing single chain antibody in various biochemical and biophysical environments
… chain variable fragment (scFv) antibody has cell-penetrating activity, nucleic acid-binding activity, nucleic acid-hydrolyzing activity, and antiviral activity. As a first step toward development of antiviral reagent using 3D8 scFv, functional stability based on DNA-binding and -hydrolyzing …
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Antiviral activity of 3D8 single chain Fv against RNA virus infection
… 3D8 single chain variable fragment (scFv) has cell-penetrating activity by electrostatic interaction with cellular membrane and it localizes in cytosol resulting in cell death by cellular rRNA degradation. These result mean that 3D8 scFv would also have potential activity as an intracellular …
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Effect of disruption of 3D8 complementarity-determining regions on properties of 3D8 antibody
… DNA-binding/-hydrolyzing, heparin-binding and cell-penetrating activities. We generated single CDR-disrupted antibodies in the formats of scFv (sc-H/LCDRi; inactivated-CDR of variable domain of heavy or light chain in scFv format), VH (H-CDRi; inactivated-CDR of variable domain of heavy chain …