Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"Cell-mediated cytotoxicity"”.
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Nonspecific Cell-Mediated Cytotoxicity in the Cat
Using a chromium-51-release microcytotoxicity assay, naturally occurring cytotoxic cells were demonstrated in peripheral blood and spleens of domestic cats. Lymphocytes from blood and spleen were purified over Ficoll-Hypaque and added to uninfected, vaccinia-infected, or herpes-infected adherent …
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Cell-Mediated Cytotoxicity of Jensen Tumor in Sprague-Dawley Rats
<p>An in vitro system for the study of the cell-mediated immune response to Jensen Sarcoma (JS) is described. The tumor grew unrestricted and lead to the demise of 80% of successfully challenged Sprague-Dawley rats (persistors) while 20% of challenged rats (regressors) destroyed the tumor by an …
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Effect of Entinostat On Nk Cell-Mediated Cytotoxicity Against Os Cells and Os Lung Metastsis
… HDAC inhibitor entinostat on the efficacy of NK cell therapy for OS lung metastasis. The Lung is the most common site of OS metastatic spread in OS and pulmonary metastasis is the main cause of mortality. We have previously demonstrated that NK cell therapy has minimal efficacy against OS …
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Intracellular Calcium and Protein Kinase C Regulate Nonspecific Cell-Mediated Cytotoxicity by Mouse Lymphocytes (Calmodulin)
… other stimulus-response couplers in lymphocyte-mediated cytotoxicity was examined through the use of various pharmacological agents. The calcium ionophore A23187 caused a marked increase in nonspecific cytotoxicity by mouse spleen lymphocytes against SV3T3 target cells. Using a standard …
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Dietary Omega-3 Fatty Acids, Cell-Mediated Cytotoxicity and Anti-Tumorigenic Activity in Balb/c Mice
… effects of an increased consumption of 18:3n-3: cell-mediated cytotoxic (CMC) activity and tumor growth. The most likely mechanism by which dietary 18:3n-3 will alter CMC and tumor growth is through changes in eicosanoid production. One study demonstrated that feeding a diet containing 10% by …
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Suppression of NK cell-mediated cytotoxicity and immunoenhancement of CD40 ligand against porcine reproductive and respiratory syndrome virus
… Arterivirus). PRRSV has a restricted host and cell tropism, with porcine alveolar macrophages (PAMs) as important host cells. In 2006, most swine farms in China experienced a “high fever disease of swine” caused by new PRRSV variants, which led to great economic losses to Chinese swine …
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Studies on the mechanism of human natural (NK) cell-mediated cytotoxicity (CMC): the role of lipoxygenation and arachidonic acid metabolites in NK-CMC
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Estrogen Inducible Serpin, Proteinase Inhibitor 9, in Immunosurveillance and Apoptosis
… a great deal of recent interest. In MCF-7 cells, we find that 10 nM genistein induces PI-9 as effectively as saturating E2, and genistein treated MCF-7 cells are resistant to NK cell mediated cytotoxicity. In ERalphaHA cells, the dose response curves for induction of PI-9 by E2 and by …
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Investigating the Impact of K+ Channel Expression on Mechanosurveillance of Disseminated Cancer Cells
Cellular stiffness profoundly impacts cancer metastasis at multiple levels, but mechanisms that regulate cancer cells’ stiffness remain poorly understood. Here, we identified potassium efflux and KCNMB1, an auxiliary subunit of the large conductance potassium efflux (BK) channels, as regulators of …
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Effect of platinum chemotherapy on tumour infiltrating immune cells in metastatic ovarian cancer: Mechanistic insights and therapeutic applications
… to what extent innate Natural Killer (NK) cells contribute. Using two syngeneic models (UPK10 and ID8p53<sup>-/-</sup>) of metastatic ovarian cancer this thesis found that treatment with carboplatin upregulates NK cell activating receptor ligands, induced a pro-inflammatory phenotype and …
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NK Cells and Their Role in Disease and Cancer Treatment
Natural killer (NK) cells are a crucial part of the human immune system. They play an important role in fighting and controlling viral infections as well as killing cells that have transformed into tumors. NK cells are involved in the pathogenesis of a number of diseases and in this thesis we will …
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Il-1Α Blockade Reduces Immune Suppression In The Early Tumor Micro-Environment
… However, a major barrier against effective T cell mediated cytotoxicity is immunosuppression in the tumor micro-environment. It has been described that tumors secrete pro-inflammatory cytokines capable of modulating immune responses that favors the growth of tumor cells. Specifically, IL-1 …
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Cell-mediated immunity in Marek's disease virus-infected chickens genetically selected for high and low levels of plasma corticosterone
… stress, HPC chickens demonstrated a decreased cell-mediated cytotoxicity (CMC) in comparison with LPC chickens. In both steroid lines, CMC decreased with the onset and severity of tumors. The impaired CMI seen in the HPC line corresponded with an increased tumor incidence and a greater …
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Developing Novel Approaches to Improve Response to T Cell Based Cancer Immunotherapy
<p>Recently, T cell based immunotherapies have moved to the forefront of cancer immunotherapy with the success of Adoptive T cell therapy (ACT) and Immune checkpoint blockade.ACT, where patients are treated with tumour infiltrating T cells (TILs), conferred a clinical response rate of ~50%. …
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Synergistic anti-tumor immune response to combination immunotherapy consisting of anti-tumor antibodies, extended half-life Interleukin-2, and other immunomodulatory agents
… have generally focused on either stimulating T-cell immunity or driving antibody-directed effector functions of the innate immune system such as antibody-dependent cell-mediated cytotoxicity (ADCC). However, as our understanding of antitumor immune responses grows, it has become increasingly …
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The Activity of Breast Milk and Monoclonal HIV-specific Antibodies in Mother-to-Child Transmission
… antibodies (nNAbs) capable of antibody dependent cell-mediated cytotoxicity (ADCC) were detected in the BMS from all 19 women. BMS ADCC activity was associated with envelope-specific IgG titers (p = 0.014) and was inversely associated with infant infection risk (p = 0.039). Our data indicate that …
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Study of Natural Killer Cells and Their Therapeutic Role in Pediatric Cancer
<p>NK cells are known to play an important role in the natural defense against viral infections and tumor immune surveillance. Through complex interactions between NK cell receptors and target cell ligands, transformed or unhealthy cells are identified and rapidly eliminated. NK cells have been …
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Augmenting Natural Killer cell antibody binding to enhance ovarian and prostate tumor cell killing via ADCC
… deaths worldwide. Natural killer (NK) cells are cytotoxic lymphocytes that rapidly kill tumor cells via antibody-dependent cell-mediated cytotoxicity (ADCC). ADCC is exclusively mediated by the IgG Fcγ receptor (FcγR) CD16A, and many clinically successful therapeutic monoclonal …
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