Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"Cell-matrix interactions"”.
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Vasculogenic Scaffolds: How Cell-Cell and Cell-Matrix Interactions Regulate Vascular Differentiation and Morphogenesis
… is to investigate the vasculogenic potential of cells seeded on two different scaffolds, a commercially available collagen cell carrier (CCC) and the vitelline membrane (VM) from a chick egg. Two cell types with vasculogenic potential were used in this study, human umbilical vein endothelial …
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Fabrication of tissue engineering scaffolds with spatial control over architecture and cell-matrix interactions in 3D
… a well-defined three-dimensional arrangement of cells. Spatial control of scaffold elements may be used to encourage the organization of cells into conformations resembling those of native tissue. Patterned scaffolds can be used to explore the healing process and then to design scaffolds with …
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Cell-matrix interactions : collagen-GAG scaffold fabrication, characterization, and measurement of cell migratory and contractile behavior via confocal microscopy
… collagen scaffolds are an analog of the extracellular matrix and are used for many tissue engineering applications. While material and microstructural properties significantly affect overall scaffold bioactivity, the specific influence of construct mechanical properties, composition, and pore …
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Physicomechanical Response of Ionic Polyurethanes on Endothelial Cells
… composition and by regulating inter-segmental interactions. We aim to use ionic PUs as representative vascular graft material to analyze the response of human endothelial cells and correlate it to cell-matrix interactions. We propose to use polycaprolactone-based ionic PU and design a composite …
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Microengineered responsive platforms for spatial and geometrical control of multicellular organizations
Living systems are composed of complex multicellular organizations containing various cell types spatially distributed in defined microenvironments. The intricate cell-cell and cell-matrix interactions in these microenvironments regulate the cell fate, differentiation of the cells, and functions of …
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Microrna-200 Regulates Ecm-Dependent Β1-Integrin/Fak Signaling and Cancer Cell Invasion
… have shown that the miR-200/Zeb1 axis regulates cell-cell and cell-matrix interactions, but it has also been demonstrated that cell-intrinsic changes are insufficient to drive cancer cell invasion, leading us to focus on specific cell-matrix interactions required to activate tumor cell invasion …
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Probing the role of cell-cell interactions in hepatic ensembles
… is scarce. Alternatives such as engineered cell-based therapies aim to restore tissue-specific functions of solid organs, but leave much to be desired. Key challenges hindering the translation of cell-based therapies relate to (1) cell sourcing, (2) graft scale-up, and (3) vascularization, …
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Impact of the Tumor ECM Niche On AML Drug Sensitivity: A Comparative Screening Study
… and drug resistance are strongly shaped by interactions between leukemic cells and the extracellular matrix (ECM) within the bone marrow niche. These ECM-driven signals promote cell survival and reduce therapeutic sensitivity, contributing to treatment failure and relapse. Traditional …
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Assessment of collagen based polymer scaffolds for tissue engineering
… both in vivo and in vitro engineering of complex cellular systems, with significant progress being prevented by a lack of biological knowledge concerning cell-matrix interactions, cell-cell interactions, and matrix-cytokine interactions. Despite this lack of knowledge, collagen based polymers …
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Glycosaminoglycan biosynthesis controls C. elegans vulval morphogenesis and is required for the first cell division during embryogenesis
… is critical to the development of multicellular organisms. Morphogenesis is also a complex process that requires the coordination of many events, including cell division, cytoskeletal reorganization, cell-cell and cell-matrix interactions. To investigate a driving mechanism of …
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Roles of Heparan sulfate in mesendoderm differentiation of human embryonic stem cells
Human embryonic stem cells (hESCs) are remarkable for their ability to self-renew indefinitely and differentiate into any cell type in the human body. The differentiation of hESCs is regulated by intrinsic and extrinsic signals in the stem cell niche. Heparan sulfate proteoglycans (HSPGs) are found …
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PHENOTYPIC AND MOLECULAR CHARACTERIZATION OF A NOVEL P63ALPHA;KO MOUSE MODEL
… of epidermal gene expression and is crucial for cell proliferation, cell adhesion and stratification. Here we describe a new p63α-/- mouse model in which we delete exon 13 leading to the expression of the p63β isoform. Newborn p63α-/- mice die soon after birth and are characterised by cleft …
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Nephrotic Syndrome and Glomerular Basement Membrane: Genetic Defect of the Laminin α5 Chain
… regulation of actin cytoskeleton dynamics and cell-matrix interactions. <br></br><br></br> The laminin α5 chain is a 404 kDa protein essential for embryonic development and, in association with laminin β2 and laminin γ1, it is a major component of the glomerular basement membrane. Mutations in …
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A microfabricated 3D tissue engineered "Liver on a Chip" : information content assays for in vitro drug metabolism studies
… bed includes signaling mechanisms mediated by cell-cell and cell-matrix interactions, soluble factors, and mechanical forces. This thesis focuses on the design, fabrication, modeling and characterization of a microfabricated bioreactor system that attempts to mimic the in vivo microenvironment …
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Mechanics and transport characterization of bioengineered tissue microenvironment platforms
… heterogeneous mechanical and biophysical cues. Cellular components are surrounded by extracellular matrix and interstitial fluid, while transport of nutrients and biochemical factors is achieved via the vasculature. Each constituent of the tissue microenvironment can play a significant role in …
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The interaction of angiocidin and tissue transglutaminase
… source of these environmental signals is the interactions between the cell and the extracellular matrix (ECM). Cell adhesion molecules are found on the surface of all cells and play a role in cell-cell and cell-extracellular matrix interactions. Tissue transglutaminase is ubiquitously …
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Multi-Omics Analysis of 3D SKOV3 Ovarian Cancer Model Cell line Cultured on Novel Silicon-Titanium Diboride Micropatterned Substrate
… effective screening approaches. Advanced cell culture platforms have emerged as key interdisciplinary field in tissue engineering and regenerative medicine. In cancer research, modeling the in vivo tumor remains a challenge. The conventional 2D culture platforms are still widely used for …
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Adhesion-GPCRs in cancer progression and metastasis
… (GPCRs), are characterized by an extended extracellular region linked to a seven-pass transmembrane moiety via GPCR proteolytic site (GPS)-containing stalk region known as GAIN domain. The name adhesion refers to the presence of functional domains in the extracellular region that commonly …
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Freezing-induced deformation of biomaterials in cryomedicine
… temperature treatments of biological proteins, cells and tissues for cryopreservation, materials processing and cryotherapy. Lack of proper understanding of cryodamage that occurs during these applications remains to be the primary bottleneck for development of successful tissue cryopreservation …
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