Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 247 for “"Cell-level"”.
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Quantitative investigation of bacterial chemotaxis at the single-cell level
Living cells sense and respond to constantly changing environmental conditions. Depending on the type of stimuli, the cell may response by altering gene expression pattern, secreting molecules, or migrating to a different environment. Directed movement of cells in response to chemical stimuli is …
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Integrating Cell-level Kinetic Modeling into the Optimization of Cancer Therapeutics
… to modify the functional response of the cell, such as cell growth or cell division. Targeting receptor systems by competitive inhibition is the objective of various protein drugs in development and on the market. Many targeted receptor systems also constitute a degradation mechanism for …
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Regulation of the Anaphase-Promoting Complex Examined at the Single Cell Level
<p>Cell cycle transitions are driven by oscillations of cyclin-cyclin dependent kinase (CDK) activity and associated cyclin degradation, mediated by ubiquitylation by the anaphase-promoting complex (APC). In this work, I analyzed the regulation of the APC by its activator Cdh1 in budding yeast in …
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Quantification of microRNA regulation and its consequences at the single cell level
… have been found to participate in almost every cellular process and their dysregulation is associated with many diseases. miRNAs recognize their targets by base paring to miRNA response elements (MREs), which are predominantly located at 3' untranslated region (3'UTR) of mRNAs. This thesis …
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Biomechanics of the cerebrum at finite strain : a tissue and cell level study/
… of the cerebral cortex at the macroscopic tissue level and at the microscopic cell level. Unconfined uniaxial compression tests were conducted in vitro on cortical samples of porcine brains. The tests consisted of load-unload and relaxation segments to 50% nominal deformation at 0.01 to 10 s-1 …
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A toolset for linking phenotype and gene expression at the single-cell level
The development of single-cell RNA-sequencing has led to a new degree of resolution in the characterization of complex, heterogeneous biological systems. However, existing methods are often limited in their ability to link these whole-transcriptome profiles with complimentary measurements of …
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Gene expression profiling in different stages of development of Arabidopsis thaliana leaftrichomes at the single cell level
Each organ of a multicellular organism is unique at the level of its tissues and cells. Furthermore, responses to environmental stimuli or developmental signals occur differentially at the single cell or tissue level. This underlines the necessity of precise investigation of the “building block of …
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Protein Analysis at the Single Cell Level by Nonlinear Laser Wave-Mixing Spectroscopy for High Throughput Capillary Electrophoresis Applications
… BAGHERIFAR. Protein Analysis at the Single Cell Level by Nonlinear Laser Wave-Mixing Spectroscopy for High Throughput Capillary Electrophoresis Applications. (Under the direction of William G. Tong and Morteza G. Khaledi) Nonlinear degenerate four-wave mixing is presented as an …
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A microfluidic approach for the initiation and investigation of surface-mediated signal transduction processes on a single-cell level
… transduction processes that are induced by cellular interactions, defined events along the signal transduction cascade and subsequent activation steps have to be analyzed and then also correlated with each other. This cannot be achieved by ensemble measurements because averaging biological …
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BIOINFORMATICS ANALYSIS OF FULL-LENGTH RNA NANOPORE SEQUENCING AT SINGLE CELL LEVEL TO STUDY TRANSCRIPTIONAL AND MUTATIONAL PATTERNS IN HUMAN LEUKEMIA
… cancer originating from hematopoietic stem cells, exhibits substantial intra-tumoral heterogeneity impacting disease development, prognosis, and treatment response. However, understanding the interplay between various layers of heterogeneity at the single-cell level remains limited due to …
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A cell level automated approach for quantifying antibody staining in immunohistochemistry images. A structural approach for quantifying antibody staining in colonic cancer spheroid images by integrating image processing and machine learning towards the implementation of computer aided scoring of cancer markers.
… relies on the visual ability and experience level of the pathologist. A novel and comprehensive system for the automated quantification of antibody inside stained cell nuclei in immunohistochemistry images is proposed and demonstrated in this research. The system is based on a cellular level …
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Computational Models of Ex Vivo HIV-1 Dynamics and Fitness Across Scales
When modeling multicellular systems, we are often interested in mapping collective macroscopic behavior to cell level characteristics, and vice versa. One of the difficulties in bridging cell level and macroscopic scales is how to interpret the meaning of model parameters when moving from one scale …
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Development and experimental analysis of a novel hybrid cooling concept for electric vehicle batteries
… batteries is developed and studied at both the cell-level and pack-level experiments. The concept is based on a simple air-cooling duct that utilizes enhanced water vaporization by convection to achieve an effective cooling. A series of hydrophilic fiber channels containing a water coolant is …
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Variable dwell time verification strategies for CDMA acquisition with application to GPS signals
… (tracking). The treatment begins with the cell-level decision-making strategy, where a 'cell' describes a particular estimate of the synchronisation parameters. The optimal sequential probability ratio test, which has largely been ignored for the GPS problem, is shown to outperform the …
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INTEGRATED SINGLE-CELL MUTATION, GENE EXPRESSION AND ISOFORM ANALYSIS TO DECONVOLVE ACUTE MYELOID LEUKEMIA HETEROGENEITY
… cancer arising from the hematopoietic stem cell (HSC). As other tumor types, AMLs are characterized by multiple and interconnected levels of intra-tumor heterogeneity, including genetic (DNA mutations), phenotypic (transcriptional patterns) and ecological (interactions with host …
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Material characterization and axial loading response of pouch lithium ion battery cells for crash safety
… material characterization of lithium ion battery cell components for use in the development of an accurate and practical computational model intended to predict mechanical deformation and related short circuit behavior of Li-ion battery cells and stacks in real world impact scenarios. In an effort …
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Cell physiology based pharmacodynamic modeling of antimicrobial drug combinations
… these models typically lack a representation of cellular processes and cell physiology, the mechanistic integration of drug action is not possible on the cellular level. The cellular mechanisms of drug action, however, are particularly relevant for the prediction, analysis and understanding of …
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Controlling Microbial Adhesion to the Surfaces Using Topographical Cues
… model surfaces is analyzed at single-cell level. The results reveal similarities between the effect of topography on bacteria-surface interactions and vesicle-surface interactions. The results are discussed in the context of controlling bacterial adhesion to surfaces using nanofibrous …
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