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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 32 for “"Cell-cycle checkpoint"”.

  1. Quantitative Analysis of a Cell Cycle Checkpoint in Xenopus laevis Cell-Free Egg Extracts

    Auckland, IanVirginia Tech2005

    In somatic cells, checkpoint pathways trigger cell cycle arrest in response to unreplicated or damaged DNA by inhibiting the activity of cyclin-dependent kinases (Cdks). In the Xenopus laevis embryo, checkpoints are not operational until the midblastula transition (MBT). Studies in cell-free egg …

    vt Repository record

  2. Role of Fanconi anemia type C (FANCC) and its cooperation with tumor suppressor P53 in cell cycle checkpoint control, apoptosis, and tumorigenesis

    Freie, Brian W.2003

    iupui Repository record

  3. The Role of Chk2 and Wee1 Protein Kinases during the Early Embryonic Development of Xenopus laevis

    Wroble, Brian NoelVirginia Tech2005

    In somatic cells, when DNA is damaged or incompletely replicated, checkpoint pathways arrest the cell cycle prior to M or S phases by inhibiting cyclin-dependent kinases (Cdks). In Xenopus laevis, embryonic cellular divisions (2-12) consist of rapid cleavage cycles in which gap phases, checkpoint …

    vt Repository record

  4. Tyrosine 370 Phosphorylation of Atm Positively Regulates Dna Damage Response

    Lee, Hong-Jen2015

    … irradiation (IR)-induced foci formation, cell cycle checkpoint, and apoptosis. However, how upstream signaling regulates ATM is not completely understood. Here, we show that upon IR stimulation, ATM associates with and is phosphorylated by epidermal growth factor receptor (EGFR) at Y370 at …

    uthsc Repository record

  5. Cell cycle checkpoints and checkpoint kinases in the apicomplexan parasites Plasmodium and Toxoplasma

    Johnson, MoniqueUniversity of Cambridge2024

    … issue. DNA repair mechanisms and particularly cell cycle checkpoint mechanisms in *P. falciparum* are not well characterised. A greater understanding of these is required, especially as artemisinin- resistant parasites have a dormancy phenotype that resembles a cell cycle checkpoint. …

    cambridge Repository record

  6. In-depth bioinformatics analysis of the phosphoproteome of triple negative breast cancer treated with a tumor selective NQO1 bioactivatable drug

    Roy, Gitanjali2021

    … in the proteome of triple negative breast cancer cells in response to a novel bioactivated anti-cancer agent IB-DNQ (isobutyl-deoxyniboquinone). NQO1 or NADPH:quinone oxidoreductase-1 is a detoxifying enzyme overexpressed in many solid tumors and low expression in normal cells. IB-DNQ is …

    iupui Repository record

  7. JAG1 Blockade With oHSV Polarizes Macrophages to Create a Unique Vulnerability for Cetuximab-Mediated Senolysis of Glioma Cells

    Rivera Caraballo, Kimberly Ann, <p>https://orcid.org/0000-0001-9275-7286</p>2027

    … CAN-3110. Since JAG1 is expressed on both glioma cells and tumor-associated macrophages (TAMs), and its expression correlated with a worse prognosis, we engineered a JAG1-antagonizing oHSV (OncoD-0J1) and interrogated its impact on the tumor and myeloid TME. OncoD-0J1 antagonized JAG1-mediated …

    uthsc Repository record

  8. GCN2 eIF2 Kinase Promotes Prostate Cancer by Maintaining Amino Acid Homeostasis

    Cordova E., Ricardo A.2024

    … and metabolism that drive prostate tumor cell proliferation. Inhibition of GCN2 results in lowered expression of AA transporters, leading to severe depletion of intracellular AA and reduced proliferation in PCa. We identified purine biosynthesis as a key metabolic pathway dependent on …

    iupui Repository record

  9. Artemis Interacts With The Cul4A Ubiquitin E3 Ligase Complex and Regulates The Cell Cycle Progression

    Yan, Yiyi2011

    … ATM and ATR in response to a variety of cellular stresses. Artemis has important roles in V(D)J recombination, DNA double strand breaks repair and damage-induced cell-cycle checkpoint regulation. The detailed mechanism by which Artemis mediates its functions in these cellular pathways …

    uthsc Repository record

  10. Cell Cycle Progression Effects of Albumin

    Uddin, SharmeenThe Graduate School and University Center of The City University of New York2020

    <p>Progression through G<sub>1</sub> phase of the cell cycle is controlled largely by growth factors in early G<sub>1</sub> and by nutrients in late G<sub>1</sub> indicating sufficient raw material for cell division. We previously mapped a late G<sub>1</sub> cell cycle checkpoint for lipids …

    cuny-grad Repository record

  11. CCAAT/Enhancer Binding Protein Alpha in UVB Responses in Human and Mouse Skin and Mouse Skin Tumorigenesis

    Thompson, Elizabeth Ellen Anderson2010

    … induced by DNA damage and has a role in the G1 checkpoint. Here we demonstrate C/EBP alpha is induced in the epidermis of the human subjects exposed to UVB. To begin to determine the in vivo physiological significance of the up-regulation of C/EBP alpha by UVB, we generated an epidermal specific …

    ncsu Repository record

  12. In vivo and in vitro studies of immunodeficiency in Ataxia-telangiectasia

    Carney, Ellen F.University of Birmingham2011

    … in the ATM gene which has a central role in the cellular response to DNA double strand breaks, cell cycle checkpoint control and initiation of the intrinsic pathway of apoptosis. Ataxiatelangiectasia is classified as an immunodeficient disorder with patients commonly showing lymphopenia and …

    birmingham Repository record

  13. Alteration of differentiation and growth of normal human epidermal keratinocytes by benzo[a]pyrene and arsenic

    Perez, Damon Scott, author, Campain, Julie, advisor, Yang, Raymond Shih-hsien, 1940-, advisor, Legare, Marie E., committee member, Fox, Michael, committee member, Ranu, Rajinder S., committee memberColorado State University. Libraries2005

    … in the malignant transformation process in human cells. Initially, the cytotoxicity of four petroleum-derived hydrocarbons [benzo[a]pyrene (BaP), carbazole, dibenzothiophene, and isoquinoline] was investigated using the MTT assay; however, the research direction changed to focusing on examining …

    colostate Repository record

  14. Medulloblastoma: New animal models, preclinical drug testing, and characterising immune infiltrates

    George, Courtney M.Edith Cowan University, Research Online, Perth, Western Australia2022

    … that combines conventional chemotherapies with a cell cycle checkpoint kinase inhibitor, and (3) investigating the effects of clinically used chemotherapies on immune cell populations in the brains of medulloblastoma-bearing mice. Currently, the limited availability of preclinical mouse models …

    edithcowan Repository record

  15. Functions of Human DNA2 and its Protein Partners in DNA End Resection

    Pinto, Cosimo2017

    … have essential roles in DNA metabolism. In human cells DNA2 was implicated in the completion of DNA replication and the repair of DNA double- strand breaks via the homologous recombination pathway. In addition, DNA2 was shown to be important for telomeric and mitochondrial DNA maintenance as well …

    zurich

  16. Functional Analysis of the Human SMC5/6 Complex in Homologous Recombination and Telomere Maintenance

    Potts, Patrick Ryan2010

    … of MMS21 by RNA interference (RNAi) sensitizes cells toward DNA damageinduced apoptosis. This hypersensitization of MMS21-RNAi cells is not due to a defect in DNA damage-induced cell cycle checkpoint, but rather in the kinetics of DNA damage repair. Since the yeast SMC5/6 complex has been …

    utswmed Repository record

  17. The DNA damage response to ATR inhibition

    Lloyd, RebeccaUniversity of Cambridge2021

    … DNA damage response and coordinates DNA repair, cell cycle checkpoint engagement, and DNA replication to ensure genome stability. To achieve this, ATR signalling often cooperates with, or antagonises, other DNA repair pathways, including many known and predicted interplays with the related kinase …

    cambridge Repository record

  18. Role of Chk1 and Chk2 in mitotic checkpoint control in vertebrate cells

    Oehler, VerenaUniversity of Glasgow2008

    … to genotoxic stress and mediate multiple cell cycle checkpoint mechanisms that ensure genomic integrity. The establishment of mitotic checkpoint delay in response to DNA damage or incompletely replicated DNA is conventionally thought to be accomplished through inhibition of the …

    glasgow Repository record

  19. Understanding the activation mechanism of the Chk1 kinase

    Zhang, YueUniversity of Cambridge2019

    … of duplicated chromosomes into two daughter cells are essential to ensure genome integrity and cell survival. Genome integrity is constantly threatened by endogenous and exogenous sources of DNA damage. Consequently, eukaryotic cells have evolved the DNA damage response (DDR), a signalling …

    cambridge Repository record

  20. Phopsphorylation and Ubiquitin Modification At Dna Damage Sites In Response to Double-Strand Breaks

    Paul, Atanu, <p>http://www.orcid.org/0000-0003-2241-5066</p>2019

    … of cancer development. To overcome this, cells have evolved a sophisticated sensory network called the DNA damage response (DDR) comprised of a large number of distinct protein complexes categorized as sensor, mediator, transducer and effector proteins that amplify the DNA damage signal …

    uthsc Repository record

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