Global ETD Search
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Showing 1 to 4 of 4 for “"Cell-cell and cell-matrix adhesion"”.
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Multiscale modelling of cancer invasion: the role of dynamic fibre redistribution and matrix-degrading enzymes in tumour progression
… is a complex process involving the secretion of matrix-degrading enzymes that have the ability to degrade the surrounding extracellular matrix (ECM). Combined with cell proliferation and migration, and changes in cell-cell and cell-matrix adhesion, the tumour is able to spread into the …
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Mathematical modelling of cancer cell invasion of tissue: discrete and continuum approaches to studying the central role of adhesion
Adhesion, which includes cell-to-cell and cell-to-extracellular-matrix adhesion, plays an important role in cancer invasion and metastasis. After undergoing morphological changes malignant and invasive tumour cells, i.e., cancer cells, break away from the primary tumour by loss of cell-cell …
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Isoform-specific Loss of CD44 Interferes with Different Aspects of the Metastatic Process
The cell-cell and cell-matrix adhesion molecule CD44 and its numerous splice variants are involved in a multitude of physiological and pathological processes, including tumour progression. Especially variant CD44 has been implicated in metastasis formation. For long term in vivo experiments on …
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Nonlinear Nonlocal Parabolic-Hyperbolic Coupled Systems for Cancer Cell Movement and Aggregation
Cells adhere to each other and to the extracellular matrix (ECM) through protein molecules on the surface of the cells. The breaking and forming of adhesive bonds, a process critical in cancer invasion and metastasis, can be influenced by the mutation of cancer cells. Several molecules have been …