Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 72 for “"Cell-cell adhesion"”.
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Reexamining actin polymerization in maintaining cadherin mediated cell-cell adhesion
Inhibiting actin polymerization disrupts the cell-cell junction showing that continuous actin polymerization is required for maintaining tissue cohesion. The actin cytoskeleton maintains cell-cell cohesion by converting weak homophilic bonds between the cadherin cell adhesion molecules into strong …
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Examining the Role and Regulation of Cell-Cell Adhesion in Aggressive Prostate Cancer
… of prostate cancer aggressiveness. The loss of cell-cell adhesion is frequently associated with the progression of prostate cancer to a metastatic state. While both adherens junctions and desmosomes are involved in establishing and maintaining this adhesion, previous studies of cell-cell …
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Regulation and Targeting of Fyn in Human Cutaneous Squamous Cell Carcinoma
… in murine epidermis and is associated with cell-cell adhesion turnover and migration. Introduction of active H-Ras(G12V) into the HaCaT human keratinocyte cell line resulted in upregulation of FYN mRNA (200-fold) and protein, but did not increase the expression of other SFKs. We identified …
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Regulation of apoptosis and desmosomes by RhoE
… skin. The epidermis is comprised of a number of cell types, the most abundant of which are keratinocytes. Normal function of the epidermis requires that keratinocyte proliferation, differentiation, and apoptosis be precisely regulated and a failure to regulate these processes is a feature of many …
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Crystallographic Studies of Cation-Glucuronic Acid Interactions: Structures of Calcium-Bromide Glucuronate and Sodium Glucuronate.
… storage, calcification, and calcium-dependent cell-cell adhesion. In 1957, Farber, Schubert and Schuster investigated the binding of sodium, potassium, and calcium cations to chondroitin sulfate polyanions.
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MODELLING CELL POPULATION GROWTH
… by the characteristics of the tissue’s extracellular matrix and constituent cells, including, but not limited to, cell membrane stiffness, cell cytoskeleton mechanical properties, and the intensity and distribution of focal adhesions over the cell membrane. To compute and study the mechanical …
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Novel Non-Repulsive Outcomes From Ephrin-B Reverse Signaling
… signaling has long been established as one of cell-cell repulsion, elicited through a localized breakdown of the actin cytoskeleton. In contrast to this dogma, I have found that ephrin-B reverse signaling is instead necessary for mediating cell-cell adhesion events during several critical …
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Engineering biomaterial surfaces with N-cadherin
… is a key protein that is responsible for cellular adhesion to neighboring cells in mesenchymal tissues. It plays a significant role in neural development, regeneration, and pathological processes. Recently, efforts were increasingly made to better understand biological function of …
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Characterization of the Effects of bFGF and GSK3β Inhibitors on Embryoid Bodies Derived from Human Pluripotent Stem Cells
… common first step in many human pluripotent stem cell (hPSC) differentiation protocols. Previous work suggests that EBs are sensitive to growth factor withdrawal if they are derived from hPSCs maintained in feeder independent media such as mTeSR1. To promote cell survival, EBs generated from …
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Cell culture platforms with cell-cell adhesive ligands for biomedical applications
Cell behavior is regulated by a number of different mechanical and chemical cues within the extracellular microenvironment, including the surrounding matrix and neighboring cells. Although biomaterials have been engineered to present several adhesion molecules that mimic cell-extracellular matrix …
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Function and Regulation of the Cell Fate Determinant Numb in Polarized Epithelial Cells
Cell polarity is fundamental to numerous cellular processes including migration, molecular transport, and cell division. The establishment and organization of polarity is crucial to the maintenance of cellular homeostasis in mammalian systems. Deregulation of cell polarity is observed in disease …
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Purinergic Signaling Regulates Filopodia-Induced Zippering
… of the adenosine receptor A2B (A2BR) induces cell-cell adhesion to promote barrier function. This barrier function is known to be important in maintaining homeostasis during hypoxia, trauma, and sepsis. Loss of this epithelial barrier function provides a considerable advantage for carcinoma …
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Mathematical modelling of cancer cell invasion of tissue: discrete and continuum approaches to studying the central role of adhesion
Adhesion, which includes cell-to-cell and cell-to-extracellular-matrix adhesion, plays an important role in cancer invasion and metastasis. After undergoing morphological changes malignant and invasive tumour cells, i.e., cancer cells, break away from the primary tumour by loss of cell-cell …
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Isoform-specific Loss of CD44 Interferes with Different Aspects of the Metastatic Process
The cell-cell and cell-matrix adhesion molecule CD44 and its numerous splice variants are involved in a multitude of physiological and pathological processes, including tumour progression. Especially variant CD44 has been implicated in metastasis formation. For long term in vivo experiments on …
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Development and application of a high throughput cell based assay to identify apoptosis inducing proteins, and functional characterization of the candidate Vacuole Membrane Protein 1 (Vmp1)
… upon overexpression. To achieve this, a cell-based high throughput assay was developed. The assay is based on the detection of activated caspase-3 in cells overexpressing proteins tagged C- and N-terminally with YFP. Apoptotic cells were detected by staining with a specific antibody …
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Effects of three-dimensional culture conditions on skeletal muscle myoblasts
… this model to investigate mechanisms of myoblast adhesion, fusion, and differentiation. C2C12 cells were examined as pre-aggregated single cells and multicellular aggregates in the Rotary Cell Culture System (RCCS). At the time intervals tested, RCCS cultured cells maintained viability and did not …
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The Localization of β-catenin During Xenopus Kidney Development: A Look into β-catenin's Role in Kidney Development
<p>Wnt signaling is a conserved cell communication system that drives embryonic development. Wnt pathways regulate a variety of developmental processes, including cell migration, proliferation, and fate determination. Dysregulation of Wnt signaling can lead to developmental disorders and diseases. …
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Regulation of Cell Adhesion By The Ferm Proteins, Ptpn14 and Merlin
<p>Cell-cell adhesion is critical for the control of tissue organization and homeostasis. A family of proteins that regulate cell-cell adhesions is the FERM (<strong>4</strong>.1 protein, <strong>E</strong>zrin, <strong>R</strong>adixin, <strong>M</strong>oesin) domain-containing proteins.One FERM …
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The Role of Daam1 In Kidney Development
… mesodermally derived aggregates of progenitor cells. The nephric progenitors organize into nephric tubules lined with hair-like sensory projections called cilia. Many diseases of the kidney are characterized by abnormal nephron morphology with current treatment aimed at symptom control. To …
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