Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 93 for “"Cell-Penetrating"”.
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Cell penetrating peptide for ocular drug delivery
… and the vasculature of the eye, leading to cell death, vascular permeability and vision loss. Cx43 HC block has proven to be effective in inhibiting the inflammatory cascade in various in vitro and in vivo ocular models. Gap19 is an intracellularly acting connexin mimetic peptide, said to be …
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Novel cell-penetrating peptide-based vectors for siRNA delivery
… charge of siRNA creates a hurdle for intracellular delivery that has thus far limited its development as a therapeutic. Cell penetrating peptides (CPPs), such as the Antennapedia homeodomain (AntpHD) and its third helix, Penetratin, are well characterised cationic motifs used previously to …
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Smart Cell-Penetrating Peptides. Strategies to regulate cellular uptake
Contains fulltext : 157591.pdf (Publisher’s version ) (Open Access)
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USING A NOVEL CELL- PENETRATING PEPTIDE TECHNOLOGY TO INDUCE PLURIPOTENCY
<p>Somatic stem cells have been used as a regenerative medicine tool to treat diseases like leukemia for decades, but they are limited in their ability to self-renew and differentiate. A better alternative, induced pluripotent stem cells (iPSCs), has the ability to generate cells from all three …
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Amphiphilic Cell-Penetrating Hybrid Cyclic-Linear Peptides as a Drug Delivery System
… their ability to deliver, fluorescence-labeled cell-impermeable negatively charged phosphopeptide (F′-GpYEEI), and fluorescent labeled anti-HIV drugs (F′-FTC and F′-d4T). The results indicated that the presence of positively charged arginine residues on the ring and hydrophobic tryptophan …
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Characterization of cell-penetrating peptide/nucleic acid nanocomplexes and their cell-entry mechanisms
… neist on rakku sisenevate peptiidide (RSP; i.k. cell-penetrating peptide, CPP) kasutamine. RSP-d on lühikesed, enamasti katioonsed ja/või amfipaatsed aminohappelised järjestused, mis on võimelised läbima plasmamembraani ning transportima rakkudesse erinevaid bioaktiivseid molekule. Selleks, et …
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High-Throughput Cell Penetration Assay for the Discovery of Cell Penetrating Cyclic Peptides
Cell-penetrating cyclic peptides (CPPs) are a promising tool in the delivery of therapeutic drugs to cells1 and can act as therapeutics themselves. These therapeutic agents are aimed at the treatment of diseases such as HIV, cancer, and multidrug-resistant bacterial diseases. Their large surface …
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Delivering Signal-Altering Bacterial Effector Proteins to Mammalian Cells Using Cell-Penetrating Peptide Technology
… of antimicrobial peptides, the modulation of the cell cycle and cell survival. Some Gram-negative bacteria have evolved needle-like structures called Type III Secretion Systems (T3SS) that secrete signal-altering molecules into the host cell to interrupt signaling pathways that would otherwise …
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Simultaneous Delivery of CRISPR/Cas Complexes and Donor DNA Using Cell-Penetrating Peptide-Adaptors
… with RNA to the nuclei of living eukaryotic cells using a novel cell-penetrating peptide (CPP)-adaptor system. Since the discovery of CPPs in the 1980s, researchers have used CPPs to deliver biomolecules such as proteins and nucleic acids into cells (the delivered biomolecules are called …
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Novel Cell Penetrating Peptides Effect Endosomal Escape and Deliver Protein Cargos into Living Cells
… that are rapidly internalized by mammalian cells have been discovered or designed. Cell-penetrating peptides (CPPs) are capable of mediating penetration of the plasma membrane, allowing delivery of macromolecular cargoes to the cell interior. We have developed a novel CPP-adaptor protein …
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Hybrid Cyclic-Linear Cell-Penetrating Peptides Containing Alternative Positive and Hydrophobic Residues as Molecular Transporters
<p>The cell membrane properties create a significant obstacle in intracellular delivery of cell-impermeable and negatively charged molecules. Amphiphilic cyclic peptides containing alternative arginine and tryptophan such as [WR]<sub>5</sub> have been shown to enhance the transport of cargo …
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More ins than outs for tumour cell targeting: Combining molecular imaging probes and cell-penetrating peptides
Contains fulltext : 241556.pdf (Publisher’s version ) (Open Access)
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Transcending the Cell Fate Stereotype: Cell Penetrating Peptide Technology helps Induce Pluripotency in Multiple Cell Types
<p>Induced pluripotent stem cells (iPSCs) are one of the most promising new technologies in the field of regenerative medicine. iPSCs can be generated directly from a patient’s own fibroblast cells then converted into any cell type, thus overcoming challenges associated with embryonic stem cells …
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A New Approach to Drug Delivery: Non- Peptidic, High Load Macrocyclic Alternatives to Cell Penetrating Peptides
… functionalising calixarenes. The phenomenon of cell penetration is of interest where a molecule has an intracellular target, for example gene therapy, delivery of cytotoxic agents or cellular imaging. Chapter 2 introduces the mechanisms of cell uptake and the design and applications of cell …
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Cyclic and Linear Peptides Containing Tryptophan and Arginine Residues as Cell-Penetrating Peptides and Antifungal Agents
… examined as potential molecular transporters and cell-penetrating peptides (CPPs), and their efficiency in delivering cell-impermeable compounds was compared with [WR]5. The peptides showed no significant cytotoxicity in different cell lines (MDA-MB-231, SK-OV-3, and HEK-293) at a concentration of …
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Amphiphilic Cyclic Cell-Penetrating Peptides Containing Tryptophan and Arginine as Anticancer Agents and Drug Delivery System
<p>Amphiphilic cyclic cell-penetrating peptides composed of an increasing number of alternative tryptophan (W) and arginine (R) were synthesized and evaluated as a molecular transporter and for their ability to deliver doxorubicin (Dox) and large molecular weight molecules, such as siRNA and …
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