Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 24 for “"Cell-Cell interaction"”.
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Identifying the mechanism critical for proliferation, apoptosis, and cell-cell interaction in the development of mouse adrenals and gonads
… Steroidogenic factor 1 (SF1)-positive precursor cells. SF1 not only defines the steroidogenic lineages in these organs, but also controls their differentiation. In this thesis project, I used Sf1/Cre transgenic mice to generate different types of knockout models to study the development of …
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Identifcation and stablization of a novel 3D hepatocyte monolayer for hepatocyte-based applications
… indicate its monolayer morphology as well as 3D cell characteristics, which make it a promising novel hepatocyte culture model to improve the conventional 2D hepatocyte monolayer culture. Mechanistic studies revealed that the dynamic morphogenesis is mainly regulated by the balance between …
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Cell migration and alignment on mechanically controlled environment
… effect of mechanically controlled environment on cell migration and alignment in vitro. Understanding such behaviors are necessary to study wound healing of life, metastatic of cancer cells, tissue engineering, and regenerative medicines. First study is a cell migration behavior on stiffness …
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TimiGP: A Computational Framework to Determine the Tumor Immune Microenvironment Associated with Prognosis and Immunotherapy Response
… to address this challenge. Leveraging single-cell RNA-seq (scRNA-seq) and bulk gene expression data alongside clinical information, TimiGP constructs a cell-cell interaction network that elucidates the relationship between immune cell function and relevant clinical outcomes, such as prognosis …
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An individual-based GPU simulation framework for collective bacterial dynamics in swarms and biofilms
… of complex bacterial communities at single-cell resolution are now possible. Guided by these rich experimental data sets, we develop minimal individual-based models to uncover the governing forces driving the dynamics in microbial systems. Our model incorporates the biophysical processes of …
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Cadherin recognition and specificity
Cadherins are calcium dependent cell adhesion molecules. The interaction between cadherin molecules is important in establishing cell polarity, tissue identity and tissue boundary. This study focused on the mechanism of cadherin mediated cell-cell interaction and binding specificity. First, the …
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Computational methods for dissecting multicellular mechanisms of complex diseases
Single-cell genomics technologies have enabled unbiased characterization of cell types and cellular states. However, the high-dimensional nature of this data necessitates computational and statistical methods to uncover the biological processes that shape it. In my thesis research, I developed …
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Rapid design and simulation of functional digital materials
… I propagate the same abstract geometric "cell" representation of parts from the design workflow into simulation and path planning. I develop a dynamic model for simulating anisotropic, multimaterial assemblies of cells with embedded mechanical and electronic functionality based on local …
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Intravital Imaging of Dynamic Behaviors of Leukocytes in UVB-induced Skin Inflammation
… diminishes surface densities of Langerhans cells (LCs) in the epidermis of the skin. Other leukocytes, such as neutrophils and macrophages, are recruited to the irradiated sites due to chemo-attracting factors released from the altered microenvironment. However, there is little evidence …
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A Bottom-Up Assembly Of Vascularized Bioartificial Constructs Using Ecm Based Microscale Modules
… is to fabricate a 3D construct that can promote cell-cell interaction, extra cellular matrix (ECM) deposition and tissue level organization. Accomplishing these prerequisites with the currently available conventional scaffolds and fabrication techniques still remains a challenge. To reproduce the …
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Agent-based modelling of cell-cell interactions for in vitro vascular formation and cancer cell growth
… an emergent pattern in interacting endothelial cells. A cancer tumour is a different but related complex system that contains various types of cells, some of which having cancer-inducing mutations. To understand the formation of a vascular structure or a cancer tumour, it is important to …
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Cell-cell and cell-medium interactions in the growth of mouse embryonic stem cells
Embryonic stem cells serve as powerful models for the study of development and disease and hold enormous potential for future therapeutics. Due to the potential for embryonic stem cells (ESCs) to provide a variety of tissues for use in regenerative medicine, there has been great interest in the …
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Role of CD44 in Immune Functions and Endothelial Cell Injury
… to the antigen-specific receptors, the T and B cells also express a variety of adhesion molecules, which are known to participate in cell-cell interaction, migration, homing and signal transduction. CD44 is a widely distributed cell surface glycoprotein whose principal ligand has been identified …
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KUPFFER CELLS¿ MITOCHONDRIAL PLASTICITY AFFECTS SYSTEMIC IMMUNO-METABOLISM
BACKGROUND: Kupffer cells (KCs) are hepatic resident macrophages that are essential for liver physiology and contribute to the development of metabolic-associated fatty liver disease (MAFLD). Due to their high plasticity, KCs can maintain immunotolerance and mediate cell-cell interaction within the …
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Sequence-structure-function relationships of glycosyltransferases in families GT43, GT47, and GT64
Extracellular carbohydrates are an essential aspect of biology, playing central roles in cell-cell interaction, cell shape, and infectious disease. In eukaryotes, extracellular glycans and glyco-conjugates are synthesised or matured by glycosyltransferase enzymes in the Golgi apparatus. Most …
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Homeostatic mechanics for a synthetic cell: predictions on substrate anisotropies and cell-cell interactions
… one or more biological processes, which in cells are known to be highly coupled. This added complexity limits the control over the biocompatibility and biofunctionality of the designed tissues. Amongst the many degrees of freedom in question, substrate topological and mechanical properties, …
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Leveraging Microtechnology to Study Multicellular Microvascular Systems and Macromolecular Interaction
… a dynamic and coordinated fashion. The complex interactions of subsystems (in micro-scale) lead to the formation of emergent properties (in macro-scale); these are properties that are not visible if individual subsystems are studied. The inherent high-throughput characteristics of …
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Deciphering Features of Protective or Maladaptive Cellular Immunity in the Airways Following Primary and Repeated Pathogen Exposure
… from homeostatic conditions. The airway’s cellular constituents – epithelial, stromal, and immune cells – maintain local and global homeostasis by facilitating gas exchange and providing a barrier against noxious environmental agents (e.g., xenobiotics, allergens, toxins, and microbes). …
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Effects of micro- and nano-scale surface geometry on behaviors of live cells and liquid droplets
… surface geometry also affects biological cells by altering their mechanical environment. In the case of cell mechanics we generally lack even a flawed model for describing the observed behavior, so we seek to identify parameters that might simplify these cellular systems. One method that …
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Controlling Microbial Colonization and Biofilm Formation Using Topographical Cues
… topography, especially local curvature, on cell–surface and cell–cell interactions during the evolution of biofilms. I investigated the adhesion, colonization, and biofilm formation of the opportunistic human pathogen Pseudomonas aeruginosa on a solid coated in close-packed spheres of …
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