Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 56 for “"Cell-Cell Communication"”.
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Multiplexing cell-cell communication
The engineering of advanced multicellular behaviors, such as the programmed growth of biofilms or tissues, requires cells to communicate multiple aspects of physiological information. Unfortunately, few cell-cell communication systems have been developed for synthetic biology. In this work, I …
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Cell-cell communication in three dimensional microenvironments
Cellular behavior is dependent on a variety of extracellular cues required for normal tissue function, wound healing, and activation of the immune system. Removed from their in vivo microenvironment and cultured in vitro, cells lose many environmental cues and that may result in abberant behavior, …
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Mechanisms of Eph/ephrin mediated cell-cell communication
… their membrane associated ephrin ligands mediate cell-cell repulsion to guide migrating cells and axons. A peculiarity of this signaling system is that both receptors and ligands can transduce signals into the cell resulting in a bidirectional signaling mode. An important step of ephrinB ligand …
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Study of cell-cell communication using 3D living cell microarrays
Cellular behavior is not dictated solely from within; it is also guided by a myriad of external cues. If cells are removed from their natural environment, apart from the microenvironment and social context they are accustomed to, it is difficult to study their behavior in any meaningful way. To …
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Computational analysis of cell-cell communication in the tumor microenvironment
Cell-cell communication between malignant, immune, and stromal cells influences many aspects of in vivo tumor biology, including tumorigenesis, tumor progression, and therapeutic resistance. As a result, targeting receptor-ligand interactions, for instance with immune check-point inhibitors, can …
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Using heterogeneous Graph Neural Networks(hGNN) to predict cell-cell communication
… diverse computational methodologies for modeling cellular interactions using single-cell RNA sequencing (scRNA-seq) data. We evaluate the performance of Graph Neural Networks (GNNs) both with and without gene-gene edges, Contrastive Learning, and Variational Autoencoders (VAEs) across multiple …
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Consequences and Limits of Cell-Cell Communication in Airway Immune Responses
… from deadly pneumonia to chronic allergies. Cell-cell communication is an important aspect of how airway immune responses are coordinated, yet it is not fully known which airway cell types send intercellular signals, under what circumstances, and what the consequences of those intercellular …
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Genomically encoded logic gates and cell-cell communication devices for the implementation of a cryptographic hashing algorithm in living cells
Cell-cell communicaon can be harnessed to distribute tasks across different cells. Applied to biocomputaon, communicaon enables cell populaons to carry out operaons too complex to be performed in a single cell. Doing so in a predictable manner requires well characterized genec parts that can signal …
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Communication at the Cellular Level: Discovery and Application
Cell-cell communication is essential to the functioning of all multicellular organisms, and understanding these critical processes can help solve current biomedical problems. As a demonstration of the utility of this approach, existing knowledge of the interactions between B cells and T cells in …
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The Role of Gap Junctions in Congenital Diseases of the Heart
… several protein kinases that regulate myocardial cell-cell coupling. We hypothesized that mutations altering sites critical to this regulation would lead to functional or developmental abnormalities of the heart.</p> <p><strong>Methods.</strong> <em>Connexin43</em> DNA from 25 normal subjects and …
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Feedback Regulation of Human Hematopoietic Stem Cell Fate
Hematopoietic stem cell (HSC) fate decisions at least in part determine cellular composition of the hematopoietic system. It is known that differentiated blood cells produce ligands that act on HSCs to influence HSC fate. However, fundamentals underlying the feedback regulation of HSC fate are …
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Uncertainty and Generality of Transfer Learning Models in Predicting Signaling History
Proper cell-cell communication is essential for multicellular development, from embryogenesis to stem cell differentiation. To map these networks, we developed IRIS (Intracellular Response to Infer Signaling state), a semi-supervised deep learning method that fits conditional variational …
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SYSTEMS BIOLOGY APPROACHES TO DECIPHERING COMPLEX IMMUNE RESPONSES
… to comprehensively interrogate how major cell types involved in the immune system respond to immune stimuli. We created a dictionary of single-cell transcriptomic profiles of individual responses to 86 cytokines and 5 vaccine adjuvants in over 20 cell populations, representing one of the …
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Quorum Signaling and Biofilm Antibiotic Resistance Phenotypes of Nontypeable Haemophilus influenzae Clinical Isolates
… antibiotic resistance and possible roles for cell-cell communication may lead to new therapeutic options. While many fascinating findings come from studies using NTHi lab strains, the results from any one strain do not necessarily represent the entire population.
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Nutritional modeling of bacterial infections : physiology and metabolism of Pseudomonas aeruginosa during growth in cystic fibrosis sputum
… can grow to high densities in vivo (>10⁹ cells/ml lung sputum), and exacerbations associated with P. aeruginosa high density in vivo growth are primary contributors to CF morbidity and mortality. Surprisingly little is known about the catabolic processes that underlie P. aeruginosa in vivo …
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Diseased Thyrocytes Have Aberrant Communication and TNF Receptor Secretion
… to the disease process. We hypothesized that cell-cell communication is disrupted by lymphocytic infiltration and advancing fibrosis and this disruption results in altered target cell responses to immune components produced at the site of inflammation, including Tumor Necrosis …
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C-terminal lysines modulate Connexin32 turnover and its ability to suppress growth of Neuro-2a cell cultures
… of channel assembly, trafficking to the cell surface, and disassembly also contribute to the regulation of cell-cell communication. In addition to their function in GJ, connexins also regulate a variety of physiological processes by forming hemichannels that are involved in paracrine …
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Mechanistic studies on the role of extracellular vesicles in the tumor microenvironment
The transition from normal into malignant cells with acquired uncontrolled growth is a process where cancer cells viciously develop adaptive strategies to overcome microenvironmental and metabolic stress. Hypoxia, or deficient oxygen supply, is a common feature of the expanding tumor which alters …
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A Complex Systems Approach to Understanding Cells as Systems and Agents
… Boolean network (BN) models to investigate cells, the fundamental units of life, as both systems of intracellular components and the agents that interact within cellular populations. Specifically, I simulate cell-like agents composed of networks with binary-valued nodes. Agents can interact …
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