Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 799 for “"Cell type"”.
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Genomic analysis of control of cell type
… made up of hundreds of different specialized cell types. All of these cells contain the same genome, but express distinct sets of genes and proteins, which give the cells their specialized functions. Understanding how this process occurs is one of the fundamental goals of biology. Research …
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Cell-type specific cholinergic modulation of the cortex
… evidence showing how specific neuronal and glial cell types can be differentially modulated by acetylcholine (Ach), resulting in dynamic functional interactions during ACh-modulated information processing and cortical plasticity. Chapter 2 identifies somatostatin-expressing neurons as a dominant …
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Cell Type-specific Analysis of Human Interactome and Transcriptome
Cells are the fundamental building block of complex tissues in higher-order organisms. These cells take different forms and shapes to perform a broad range of functions. What makes a cell uniquely eligible to perform a task, however, is not well-understood; neither is the defining characteristic …
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Cell type-specific regulation of the chicken tyrosinase promoter
… coats of vertebrates, is synthesised by two main cell types: melanocytes and retinal pigment epithelial (RPE) cells. These two cell populations. which arise from distinct embryological origins, differ with respect to the rate at which they produce melanin and the ways in which they respond to …
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Single-Cell Language Model for Transcriptomics & Cell Type Annotation
As single-cell transcriptomics datasets continue to grow in size and biological complexity, current models for cell type annotation remain limited in their generalizability and are often evaluated on only a small fraction of the standardized cell types defined in modern ontologies. Current …
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Cell Type-Specific Contributions of FOXP1 to Human Cortical Development
Pages vi-xv are misnumbered as pages v-xiv, pages 89-129 are misnumbered as pages 87-127, and pages 130-174 are misnumbered as pages 124-168.
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Cell-Type Specific Translational Profiling in Huntington's Disease Mouse Models
… neurons (MSNs) are among the most vulnerable cell populations in Huntington's Disease (HD). Within this population, striatopallidal MSNs are more vulnerable than striatonigral MSNs, which may explain the typical progression in HD of chorea to hypokinesis. The biological basis for this …
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Antigen presentation: Influence of Cell Type and Route of Antigen Uptake
<p>Dendritic cells (DCs), which maintain tolerance and orchestrate T cell immune responses, comprise a heterogeneous group of cells. For example, in the steady state, murine spleen contains pre-DC-derived CD8+DEC-205+ and CD8-DCIR2+ conventional DCs. To examine antigen processing and presentation …
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CELL TYPE-SPECIFIC EFFECTS OF OPIOID DEPENDENCE ON CENTRAL AMYGDALA NEURONS
… that the CeA comprises multiple functional cell-types. While decades of research implicate the CeA in opioid withdrawal, the cell type-identity of the affected CeA cells has received little attention. In this dissertation, I profile a major subtype of neurons in the central nucleus of the …
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Cell Type-Specific Roles of FoxP Transcription Factors in Vocalization and Cognition
… with neurophysiological and behavioral phenotypes. Still, much remains unknown about molecular networks in the brain driven by these transcription factors, especially in specific regions and cell types. During my dissertation work, I sought to elucidate FoxP2 and FoxP1 functions in cortical, …
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Cell-Type Specific Requirement for Pyruvate Dehydrogenase in Hematopoiesis and Leukemia Development
Pages i-xii are misnumbered as pages ii-xiii, and page 142 is misnumbered as page 121.
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Cell-type specific CB1 receptor modulation of hippocampal synaptic plasticity and memory
… and learning mainly via the cannabinoid receptor type 1 (CB1)-dependent regulation of neuronal and glial activity. In the hippocampus, bidirectional communication between neurons and astrocytes shapes synaptic plasticity and behavior. CB1 receptors have been shown to be present in the astrocytes …
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Cell-type-specific responses to DNA damage from acute and chronic radiation
… H2AX. Many experiments have been performed with cell lines derived from different origins and donors which, while invaluable for studying specific effects, restrict direct assessment of response variability between different cells, tissues and individuals. This thesis investigates normal tissue …
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Viral and Cell Type Specific Host Factors that Contribute to Paramyxovirus Antiviral Responses
Activation of host cell responses during viral infection can be a critical factor in determining of viral tropism, dissemination, and pathogenesis. The paramyxovirus simian virus 5 (SV5) is able to establish highly productive, persistent infections of cultured epithelial cells with minimal …
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HECAT5 regulates cell proliferation via interaction with M3R in cell type-specific manner
Embryonic stem (ES) cells are derived from pluripotent inner cell mass of the early mammalian embryo. Their self-renewal and pluripotency make them attractive sources for stem cell therapies. For ethical and practical reasons, ES cells have a major threat limiting in potential therapeutic …
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Elucidating the structure-function relationship of the cell-type specific splicing regulator, RBPMS
… in differentiated vascular smooth muscle cells (VSMCs). RBPMS has an N-terminal RNA recognition motif (RRM) that mediates both RNA binding and dimerization, allowing binding to pairs of trinucleotide CAC motifs. The C-terminal tail is predicted to be unstructured, and such regions of other …
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Exploiting Multi-Cell Type Cultures to Elucidate Tumor Cell Features That Impact Macrophage Phenotype
… and women. Lung cancer is divided into non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) which represent 80-85% and 15-20% of cases, respectively. My dissertation project focused on understanding how to model the interactions between lung cancer cells, fibroblasts and immune …
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Deconvoluting Cell-Type Specific 3'UTR Isoform Expression in the Adult and Developing Cerebellum
… regulates these processes uniquely in specific cell types. Using a newly developed technique, termed conditionally-tagged poly(A) binding protein-mediated mRNA 3' end retrieval by crosslinking immunoprecipitation (cTag-PAPERCLIP), we discovered significant differences in alternative …
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ACUTE CELLULAR UPTAKE OF ABNORMAL PRION PROTEIN IS CELL TYPE AND SCRAPIE STRAIN INDEPENDENT
… an infected host largely remains unclear. At the cellular level, the uptake of protease resistant prion protein (PrP-res), which strongly correlates with infectivity and is a valid marker for TSE infection, is one of the earliest events that must occur during TSE infection. Given the difficulty of …
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ACUTE CELLULAR UPTAKE OF ABNORMAL PRION PROTEIN IS CELL TYPE AND SCRAPIE STRAIN INDEPENDENT
… an infected host largely remains unclear. At the cellular level, the uptake of protease resistant prion protein (PrP-res), which strongly correlates with infectivity and is a valid marker for TSE infection, is one of the earliest events that must occur during TSE infection. Given the difficulty of …
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