Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"Cell trafficking"”.
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Characterizing Roles of Host Cell Trafficking Factors in HIV Assembly and Release
… virus type-1 (HIV-1) infects and destroys immune cells (e.g. CD4+ T cells), leading to acquired immunodeficiency syndrome (AIDS). Antiretroviral therapy (ART) can suppress HIV-1 replication, but there is still no vaccine or cure. Here, we have addressed open questions about two key steps of the …
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Quantifying the role of lymphatics in lipid transport and lymphatic filariasis using novel engineering approaches
… roles in maintaining fluid homeostasis, immune cell trafficking and lipid transport from the small intestine to the venous circulation. Lymphatic vessels are the main functional organ responsible for the diverse transport roles the system plays. Unlike the blood vasculature, the lymphatic system …
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A blood exchange method to study circulation kinetics of tumor cells in the blood
Blood is an essential compartment for tumor cell trafficking. In solid epithelial-derived tumors, blood serves as the major vehicle for metastasis, whose principal cell is the circulating tumor cell (CTC). These cells originate from the primary tumor and are shed at low concentrations into the …
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Design, synthesis, and evaluation of release kinetics of novel LFA-1 and TLR-4 inhibitor prodrugs for localized immunomodulation.
… LFA-1 inhibitor compounds, which inhibit early T-cell trafficking of the adaptive immune system, and the development and evaluation of release kinetics of novel prodrugs of one of these novel LFA-1 inhibitors with poor leaving group ability under physiological conditions. Evaluation of the …
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The role of NK cells in selectin-dependent tumor suppression
… adhesion molecules that are critical for immune cell trafficking. In our laboratory, mice lacking all combinations of selectins have been generated. Previous work from our laboratory has demonstrated that, in the absence of selectins, human tumors transplanted subcutaneously into Rag2'- mice grow …
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Upper-respiratory infection triggers experimental autoimmune encephalomyelitis onset in autoimmune prone t-cell receptor transgenic mice
… to cause glial activation, promote immune cell trafficking to the CNS and trigger pathology in an autoimmune-prone T cell receptor transgenic mouse line. To test this hypothesis we infected 2D2 mice and monitored for symptoms of inflammatory demyelination (EAE). Clinical and histological …
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The multiple migratory mechanisms of systemically infused mesenchymal stem cells to sites of inflammation
Systemically infused mesenchymal stem cells (MSC) are being explored for their immunomodulatory therapeutic potential in multiple inflammatory pathologies. This therapeutic potential has been associated with the ability of MSC to accumulate at sites of inflammation following infusion. However, …
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The roles of human cytomegalovirus US27 gene product during virus infection
… involves extensive manipulation of host cellular functions and immune responses. HCMV encodes four genes for putative G protein-coupled receptors (GPCRs): US27, US28, UL33, and UL78. The US28 gene product is a functional chemokine receptor that exhibits a variety of signaling outcomes. In …
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Role of N-terminal residues of CCL19 and CCL21 in binding and activation of CCR7
… are chemotactic cytokines, which mediate cell trafficking and play a key role in mobilisation of leukocytes. More recently, chemokines and their cognate receptors have been described as key players in different aspects of cancer biology contributing to proliferation, angiogenesis and …
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Characterization of human IgA-inducing protein
… progress in characterizing the role of dendritic cells (DCs) in the activation and modulation of B cells. DC-secreted chemokines can induce B cell trafficking to the lymph nodes. DC-produced survival factors such as BAFF and APRIL have been shown to be essential for B cell maturation, but have …
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Antibody-functionalized nanoporous surfaces enable high throughput specific cell capture
Adhesion-based cell capture on surfaces in microfluidic devices forms the basis of numerous biomedical diagnostics and in vitro assays. Solid surface microfluidic platforms have been widely explored for biomedical diagnostics since samples can be precisely and reproducibly manipulated under …
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DEFINING THE FUNCTION OF RICE FLORIGENIC PROTEINS DURING THE REPRODUCTIVE TRANSITION AND INFLORESCENCE DEVELOPMENT
… co-localizing with a protein implicated in cell-to-cell trafficking. These findings increase our understanding of FT-L1’s complex role in inflorescence development and flower fertility.
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Role and Regulation of Sphingosine 1-Phosphate In Erythrocyte
… sphingolipid produced in every mammalian cell. It plays a variety of important roles both in and outside of cells. S1P is highly enriched in mature erythrocytes because of the high enzymatic activity of the S1P-generating enzyme Sphingosine Kinase 1 (Sphk1) and the absence of S1P degrading …
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Upstream Migration Under Shear Flow: Force Generation and Molecular Regulation
… behavior implicated in hematopoietic stem cell trafficking and immune cell surveillance. Despite the centrality of mechanical force to this process, the forces upstream-migrating cells generate at the cell-substrate interface have not been directly measured during sustained upstream …
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A three-dimensional agent-based model of glioblastoma with applications towards in vitro and in vivo therapy simulation
… these subtypes lead to downstream differences in cell migration speed and immune system activation status. Despite these behavioral differences, glioblastomas are treated using a uniform standard of care regardless of tumor subtype. To identify subtype-dependent features influencing tumor …
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Characterization of endothelial cells of lymphatic vessels
Endothelial cells form the inner lining of blood and lymphatic vessels. In mice only tumours of the blood vessel endothelium (haemangiomas) have been thus far reported. In the first part of this thesis is described a highly reproducible method for the induction of benign tumours of the lymphatic …
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PEDOT:PSS Enhanced Electroporation for Cell Therapy Manufacturing
Cellular immunotherapies, such as chimeric antigen receptor (CAR) T cell therapies and macrophage therapies, have shown promising results in treating a wide range of cancers. Advances in these therapies focus on increasingly complex cellular systems to simultaneously optimize immune cell …
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Characterizing RNA translocation in the parasitic weed Cuscuta pentagona
… organ known as the haustorium. Direct cell-to-cell symplastic connections between two different organisms are rare, and the translocation mechanisms and fate of these RNAs in the parasite is not understood. To characterize this phenomenon, mobile Arabidopsis and tomato mRNAs were …
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Plasma membrane calcium ATPase 4 (PMCA4) and inflammation of the aortic endothelium
… response relies on the well-coordinated trafficking of leukocytes from the circulation to sites of tissue injury. The endothelial expression of cell adhesion molecules, namely the selectin family, mediates the initial adhesive interactions between leukocytes and the endothelium. Immune …
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