Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Cell traction"”.
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Development of a novel cell traction force transducer based on cholesteryl ester liquid crystals. Characterisation, quantification and evaluation of a cholesteryl ester liquid crystal based single cell force transducer system.
In biomechano-transducing, cellular generated tension can be measured by soft substrates based on polymers but these techniques are limited either by spatial resolution or ability to detect localised cell traction forces (CTF) due to their non-linear viscous behaviour under shear rates. A newly …
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Cellular decision making at the nanoscale
The well-established dependence of cell traction forces on the compliance of supporting matrices has been attributed to levels of force exerted on components in focal contacts. Here, use of novel, force-limited nanoscale tension gauges revealed that both force and substrate deformations govern cell …
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Applications of Traction Force Microscopy in Measuring Adhesion Molecule Dependent Cell Contractility
… controlled elastic modulus substrates for single cell traction force microscopy studies. The first section describes the use of EDC/NHS chemistry to convalently link microbeads to the hydrogel matrix for the purpose of performing long-term traction force studies (7 days). The final study uses the …
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INVESTIGATING THE ROLE OF LIPID DROPLETS AS INTRACELLULAR MECHANICAL STRESSORS IN NON-ALCOHOLIC FATTY LIVER DISEASE
… markedly) is the major risk factor for hepatocellular carcinoma (HCC). Stiffness is correlated with cancer development and patient prognosis, and is used clinically in disease surveillance. However, patients with non-alcoholic fatty liver disease (NAFLD) and lipid-droplet-filled hepatocytes …
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Dendritic Cell Migration and Traction Force Generation in Engineered Microenvironments
Dendritic cells (DCs) are potent initiators of the adaptive immune response. Their trafficking from sites of inflammation to lymphoid tissue is essential to their function. Exactly how dendritic cells integrate multiple chemotactic cues to organize an accurate migratory path is not fully …
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Triggerable ligand presentation using caged-RGD
Cells rely on time-dependent binding and activation by the ECM to initiate downstream signal transduction. It is unknown whether adhesion to a ligand is required throughout various cell processes, or only during a specified time period ("temporal threshold”). Current approaches to ligand …
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Microfabrication Approaches for Understanding the Role of Vascular Mechanics in Progressive Diseases
… amyloid beta treatment on vascular smooth muscle cell functional contractility using a single-cell traction force microscopy technique and developed a thin-walled arterial model for growth and remodeling response to mechanical perturbations. We found that amyloid beta induces a reduction in …
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Cells and force transduction
… at cadherin complexes is not restricted to cell-cell junctions but is also propagated globally via the mediation of its respective RTK binding partner. These results suggest that homophilic ligation in trans- and cadherin association with cognate receptor tyrosine kinase in cis comprises a …
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Engineered hydrogels for tracking cell signaling from the outside-in
… therapies involves the conversion of somatic cells back into an embryonic stem cell (ES)-like state, termed induced pluripotent stem cells (iPS). iPS cells have the same potential for differentiation as ES cells and hold immense promise for tissue engineering, regenerative medicine, and …
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Mechanoprobe fabrication and development for mechanobiology
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-08-01
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Cancer metastasis and elasticity of microenvironment
… the parent tumor. During metastasis, malignant cells detach from the parent tumor, and spread through circulatory system to invade new tissues. Due to the intrinsic difficulties of predicting and monitoring in vivo metastasis, the physical-chemical mechanisms and parameters within the cellular …