Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 191 for “"Cell therapy"”.
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Improving Nk Cell Therapy For Osteosarcoma
… years. Adoptive transfer of Natural Killer (NK) cells holds promise for a new, non-toxic therapy for OS. NK cells are part of the innate immune system and readily kill metastatic and chemotherapy-resistant OS <em>in vitro</em> and in murine models. However, there is little data regarding their …
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B cell therapy in ANCA-associated vasculitis
… includes neutrophil activation by B cell-derived ANCAs, activation of the alternative complement pathway, and dysregulated T cell responses that result in a necrotizing vasculitis of small blood vessels. The central role of B cells is highlighted by the presence of activated B cells …
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PEDOT:PSS Enhanced Electroporation for Cell Therapy Manufacturing
Cellular immunotherapies, such as chimeric antigen receptor (CAR) T cell therapies and macrophage therapies, have shown promising results in treating a wide range of cancers. Advances in these therapies focus on increasingly complex cellular systems to simultaneously optimize immune cell …
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A Biomaterial-based Stem Cell Therapy for Retinal Regeneration
… or regenerate the retina with healthy cells to improve vision. Emerging therapies, in clinical trials, are investigating stem cell-derived photoreceptors injected, in a saline solution, into the subretinal space to replace dying cells caused by retinal degeneration. The principal …
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Protein and cell therapy for lecithin-cholesterol acyltransferase (LCAT) deficiency
… the failure to esterify cholesterol causes many cellular and metabolic disturbances. Here, I describe the purification of recombinant LCAT and assess two approaches to treat LCAT deficiency. Human LCAT cDNA was cloned into a selectable expression vector and used to generate a stably–transfected …
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Mesenchymal stem cell therapy for the treatment of myocardial infarction
Mesenchymal stem cells (MSCs) are currently under investigation as repair agents in the preservation of cardiac function following myocardial infarction (MI). However concerns have emerged regarding the safety of acute intracoronary (IC) MSC delivery specifically related to mortality, …
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Immuno-suppressive hydrogels for stem cell therapy after traumatic brain injury
… pathways. This initial insult activates multiple cellular mechanisms that further propagate the tissue damage causing a secondary injury that exacerbates neurological deficits. This phase, known as the secondary injury, opens a therapeutic window in which neuroprotective treatments that …
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The Application of Mesenchymal Stem Cell therapy on Multiple System Atrophy
… We evaluated the feasibility and safety of therapy with mesenchymal stem cells(MSCs) through consecutively intraarterial and 3 repeated intravenous injections for 3 months and compared the long-term prognosis between tow groups. The MSC-treated patients showed significantly greater …
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Overcoming Diffusion Limitations in Encapsulated Cell Therapy for Type 1 Diabetes
… from alginate, physically shields transplanted cells from rejection by the immune system. However, encapsulated islets completely rely on diffusion for nutrient delivery which can be limited by the encapsulation material, the naturally large size of pancreatic islets, and the fibrosis around the …
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Developing an Inducible Osteoclast System as a Cell Therapy for Ectopic Calcification
… mineral in vivo and we hypothesized that a cell therapy based on inducible osteoclast differentiation could be used as a cell therapy to treat EC and HO. The RANK/RANKL pathway is a critical step in osteoclast differentiation and we created an inducible RANK (iRANK) fusion protein which …
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Development of a novel imaging system for cell therapy in the brain.
… and experimental studies have evaluated stem cells as a potential therapeutic approach for several neurological disorders of the central and peripheral nervous system as well as for traumatic brain and spinal cord injury. The identification of the location, migration and biodistribution of …
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Human neural stem cells: region-specific properties and prospects for cell therapy
Cell replacement by neural transplantation can, in animal models of neurodegenerative diseases, reconstruct damaged brain circuitry. In the clinical situation, the graft material used for cell therapy must, most likely, be of human origin. The human fetal brain is one potential source of neural …
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Enhancing Chimeric Antigen Receptor T cell therapy in Mouse EGFRvIII Heterogeneous Glioblastoma
<p>Chimeric antigen receptor (CAR) T cell therapy for glioblastoma remains challenging due to insufficient CAR T cell abundance and antigen-negative tumor cells evading targeting. Unfortunately, most preclinical studies evaluating CAR T cells in glioblastoma use tumors expressing a single antigen, …
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Aorta-derived mesoangioblasts for cell therapy of cardiomyopathy in Duchenne Muscular Dystrophy
… mesoangioblasts (ADM) are multipotent adult stem cells that differentiate to adipocytes, smooth muscle cells, skeletal myotubes, oligodendrocyte precursors, and cardiomyocytes, indicating that they can be used for regeneration in severe disease in which multiple tissues are affected. Duchenne …
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Allogeneic Double Negative T cell Therapy as a Novel Treatment for AML Patients
… unmet need for a treatment that can target chemotherapy-resistant blasts with low off-tumor toxicity. Approaches to prevent GvHD while maintaining or enhancing graft-versus-leukemia (GvL) are the ‘Holy Grail’ for allo-BMT patients. CD3+ CD4- CD8- double negative T cell (DNT) is an unconventional …
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An analysis of consent with specific regard to stem cell therapy and research
This thesis argues that stem cells cannot be properly regulated when understood in terms of medical treatment only. This is due to the uncertain scope and untested efficacy of stem cell therapy which renders treatment applications tantamount to research involving human subjects. This thesis …
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Dynamics of Endogenous Cardiac Repair and Methods for Enhanced Post-Injury Cell Therapy
… was cited as a primary impediment in bone marrow cell (BMC) infusion clinical trials, Chapter 4 recapitulates these trials in an intact-organ murine model--the isolated perfused heart. Flow cytometry enables objective, sensitive identification of strongly-retained BMC phenotypes. Results show that …
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Immune Mechanisms of Mesenchymal Stem Cell Therapy for Acute Graft versus Host Disease
… was to investigate the role of Mesenchymal stem cells (MSC) in the modulation of immune responses, focusing on suppression and induction of immune tolerance. To date, MSC therapy has proved beneficial for the treatment of inflammatory and autoimmune diseases, such as acute Graft versus Host …
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Enhancing efficacy of oncolytic myxoma virus and adoptive T cell therapy against tumors
Immunotherapy in general and adoptive cell transfer in particular have recently been in the spotlight of cancer research. Recent FDA approval of the first immunotherapeutic drugs and promising results in clinical trials suggest that this therapeutic modality holds great promise in fighting cancers. …
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Multi-Pronged Approach to Understanding the Toxicity Associated with CAR T-Cell Therapy
Chimeric antigen receptor (CAR) T-cell therapy has revolutionised cancer immunotherapy, providing effective treatment for previously untreatable malignancies. Its success, in treat ment of haematological cancers, is now fast-advancing to solid tumours. Though, these efforts are faced with many …
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