Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Cell surface glycoprotein"”.
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Biochemical characterisation of a novel vaccine candidate against Trypanosoma vivax, the cell surface glycoprotein IFX
… antibody recognition of a recently discovered cell surface glycoprotein and vaccine candidate, Invariant Flagellum Antigen from Trypanosoma vivax (IFX) from the kinetoplastid parasite Trypanosoma vivax. African trypanosomes are unicellular protozoan parasites and pathogens from the family …
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Immunotherapy of Folate Receptor Expressing Cancers
The folate receptor (FR) is a GPI anchored cell surface glycoprotein that functions to facilitate folic acid uptake and mediate signal transduction. With the introduction of multiple folate-targeted drugs into the clinic, the question has arisen regarding how frequently a patient can be dosed with …
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Purification and Characterization of an Anti-Basigin Monoclonal Antibody: Application to the Study of Human Uterine Cells and Tissues
… poorly understood (S. Zhang et al., 2013). The cell surface glycoprotein basigin-2 is necessary for embryo implantation in the mouse and plays a role in several cellular functions, including cell communication and extracellular matrix remodeling (Chen et al., 2009; K. Li & Nowak, 2020). <em>In …
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Targeting the tight junction : immunotherapy of colon cancer
A33 is a cell surface glycoprotein of colon epithelium with a long clinical history as a target in antibody-based cancer therapy. Despite being present in normal colon, radio-labeled antibodies against A33 are selectively retained by tumors at long time points. Accordingly, we have studied the …
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pH MODULATION OF FIBRIL DISSOCIATION AND COPPER BINDING PROPERTIES OF THE PRION PROTEIN
<p>The cellular form of prion protein (PrP<sup>C</sup>) is a cell-surface glycoprotein attached to lipid rafts via its glycosylphosphatidylinositol anchor. Conversion of PrP<sup>C</sup> to its "scrapie" conformer (PrP<sup>Sc</sup>, the fibrillar form) constitutes the key event of the etiology of …
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pH MODULATION OF FIBRIL DISSOCIATION AND COPPER BINDING PROPERTIES OF THE PRION PROTEIN
<p>The cellular form of prion protein (PrP<sup>C</sup>) is a cell-surface glycoprotein attached to lipid rafts via its glycosylphosphatidylinositol anchor. Conversion of PrP<sup>C</sup> to its "scrapie" conformer (PrP<sup>Sc</sup>, the fibrillar form) constitutes the key event of the etiology of …
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Role of CD44 in Immune Functions and Endothelial Cell Injury
… to the antigen-specific receptors, the T and B cells also express a variety of adhesion molecules, which are known to participate in cell-cell interaction, migration, homing and signal transduction. CD44 is a widely distributed cell surface glycoprotein whose principal ligand has been identified …
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Using chemical biology as a tool to probe the mechanism of the HDL receptor
… receptor, class B, type I (SR-BI), is a cell surface glycoprotein that controls HDL structure and metabolism by mediating cellular selective uptake of lipids from HDL. The mechanism underlying SR-BI-mediated lipid transfer involves a two-step process (binding followed by lipid transport) …
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Structure of the Chicken Neuron-Glia Cell Adhesion Molecule, Ng-CAM: Origin of the Polypeptides and Relation to the Ig Superfamily
<p>The neuron-glia cell adhesion molecule, Ng-CAM, is a cell-surface glycoprotein expressed on neurons and Schwann cells in the chicken nervous system. It is expressed as a group of related components of ~200 kD, 135 kD, and 80 kD, which are detected at particular sites during development. Ng-CAM …
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Stressed Astrocytes: Insights on the Pathology of Alexander Disease
… astrocytes, and develop several forms of cell stress. However, how stressed astrocytes cause the loss of myelin in this disease is unknown. In this work I have conducted a largely immunohistological investigation of AxD patient tissue, model mice, and primary astrocytes cultured from the …