Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"Cell surface Biotinylation."”.
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Holin-dependent secretion of a large clostridial cytotoxin by C. perfringens
… and inactivate small GTPases in host mammalian cells, shutting down cell-signaling and eventually leading to cell death. Intriguingly, LCTs all lack any conventional signal peptide, rendering them incapable of being translocated by the Sec- or Tat-secretion system. However, according to recent …
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Dynamic subcellular proteomics identifies novel regulators of adipocyte insulin action
… of the glucose transporter GLUT4 from an intracellular compartment to the plasma membrane. However, our knowledge of spatial changes in response to insulin signalling is incomplete. In this thesis we used two orthologous proteomic methods to identify novel insulin-responsive protein …
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Novel Role of ErbB-2 in Inhibition of Jagged-1-Mediated Trans-Activation of Notch in Breast Cancer
… monoclonal antibody is directed against the extracellular domain of ErbB-2 and lapatinib, a dual EGFR/ErbB-2 tyrosine kinase inhibitor. Unfortunately, anti-ErbB-2 therapy resistance remains a major problem in metastatic breast cancer. Our data suggested that gene amplification or overexpression of …
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The mechanisms of aquaporin expression and translocation in cerebral pathologies
… membranes and are essential for maintaining cellular integrity. In humans, the AQP family consists of 13 established members (AQP0-12). AQPs 1, 3, 4, 5, 8, and 9 are collectively known as "cerebral AQPs" as they are known to be present in the mammalian brain. AQPs are distributed throughout a …
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The characterisation of the cell surface of Staphylococcus aureus in the search for new therapeutic targets
… including endocarditis, osteomyelitis, cellulitis, toxic shock syndrome, and necrotising pneumonia. S. aureus is a leading cause of hospital-acquired infections and has rapidly acquired resistance to multiple antimicrobials. As such, it was deemed a serious threat by the Centers for …