Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 18 of 18 for “"Cell signalling pathways"”.
-
The effects of statins on hypoxia-induced proliferation and cell signalling pathways in pulmonary artery fibroblasts
… of PAFs. Morevoer, it is likely that cell-cell interactions between hypoxia-stimulated PAFs and other vascular cells – particularly smooth muscle cells - initiates and progresses the changes that occur in pulmonary vascular remodelling in the other vessel compartments. Although hypoxic …
-
Exploring the effect of genetic calpain disruption on cell migration, invasion, drug sensitivity, and metastasis in triple negative breast cancer
… Calpains cleave substrates involved in various cell signalling pathways associated with tumourigenesis and metastasis. Based on these established roles for calpain, I aimed to further characterise the effects of calpain knockout on migration, invasion, tumour growth, and paclitaxel-induced …
-
Molecular aspects of the link between obesity, insulin resistance and breast cancer.
… progression and/or breast cancer aetiology. A cell culture system of breast cancer cells and breast epithelial cells was employed to investigate changes in cell proliferation, activation of cell signalling pathways, cell cycle progression and apoptosis after treatment with insulin, leptin, …
-
Phytochemical metabolites and their effects on in vitro and in vivo measures of oxidative stress
… to function as antioxidants and also to regulate cell signalling pathways and induce endogenous protective mechanisms is both an exciting and a complicated area of research. Currently it is known that phytochemicals can act to enhance cell survival in cells that are challenged with a cytotoxic …
-
Transcription and chromatin dynamics in the Notch signalling response
… different genes are expressed in different cell types, often directed by cell signalling pathways and the pre-existing chromatin environment. The highly-conserved Notch signalling pathway is involved in many cell fate decisions during development, activating different target genes in …
-
Examining Altered NF-κB Signalling Following 1,4- Benzoquinone Exposure in HD3 Cells
… species (ROS) production interfering with the signalling pathway involving NF-κB, p38-MAPK and c-Myb. The objectives were to determine if ROS and p38-MAPK mediate benzoquinone (BQ) induced changes in NF-κB activity, and if downstream targets of NF-κB are altered after BQ exposure. HD3 chicken …
-
The cardioprotective mechanisms of dietary flavonoids
Mitotic rat embryonic cardiomyoblast-derived H9c2 cells are widely used as a model cardiomyocyte to study the protective mechanisms of dietary flavonoids, but they lack features of fully differentiated cardiomyocytes. Therefore, this present study aimed to investigate the cytoprotective and …
-
Characterisation of the mechanisms of tumour-induced dysfunction of clonal T cell expansions in multiple myeloma
… myeloma is a cancer involving malignant plasma cells in the bone marrow. Despite advances in therapy, relapse is inevitable due to residual disease and myeloma remains incurable. New therapies are required to remove residual disease and maintain long term survival. Expanded clones of cytotoxic T …
-
The induction of long-term potentiation attenuates kainic acid-induced excitotoxicity
… relationship between synaptic plasticity and the cell-signalling pathways which ultimately determine neuronal fate. Research in our lab has indicated that NR2A-containing NMDARs are essential for LTP induction whereas NR2B-containing NMDARs are crucial for the production of LTD in vitro, and the …
-
Development and application of a high throughput cell based assay to identify novel modulators of ERK1/2 activation and,Functional characterisation of the candidate Radial spokehead like (Rshl1)
… human proteins that influence cancer relevant cellular processes like cell proliferation, signalling, and apoptosis upon over-expression. The focus of my work was 1) The establishment of a high throughput cell based assay to screen for proteins involved in the modulation of cell signalling …
-
Understanding the role of the Notch intracellular domain in transcription hub formation
Throughout metazoan development, cell signalling pathways are used to organise gene expression in different cell types at different times. Notch is a highly conserved pathway whose activity controls the expression of many targets in a context dependent manner. Despite the complexity of response, …
-
Development of coupled enzyme assay and in vitro synthetic biology approach for glycosylation pathway characterization
… metabolism all the way through to intricate cell signalling pathways. They carry out these functions either directly by participating in metabolism and binding or indirectly by altering the structure and nature of their conjugates, for example by being the major posttranslational modifier of …
-
Targeting DNA Repair in Prostate Cancer: Therapeutic Combinations & Disease Models
Targeting prostate cancer cells with DNA repair inhibitors presents an opportunity to improve outcomes in patients with poor prognosis cancers. There are multiple reasons which rationalise targeting DNA repair in prostate cancer, including the enrichment of DNA repair genetic alterations in men …
-
Investigation of key non-coding and coding genes in cutaneous melanomagenesis
… length that are found in both animal and plant cells. miRNAs are involved in the RNA interference (RNAi) machinery to regulate gene expression posttranscriptionally. miRNAs have important roles in cancer: by controlling the expression level of their target genes they can affect cell signalling …
-
Exercise-induced cell signalling responses of human skeletal responses of human skeletal muscle: the effects of reduced carbohydrate availability
… techniques now permit the examination of the cell signalling responses to acute exercise therefore increasing our understanding of how manipulation of the training protocol and nutrient availability may enhance the training stimulus to a given bout of exercise. The primary aim of this thesis …
-
Investigating transcription factor dynamics and chromatin environment during Notch response
During development, a multitude of cell signalling pathways control patterning, cell fate determination and tissue assembly. Notch signalling is one such, highly conserved, pathway in multicellular animals that regulates a large diversity of developmental processes. Its function is crucial for …
-
Mechanisms of glucocorticoid pro-inflammatory effects on CCL20: crosstalk and synergy
… pro-inflammatory genes via its endogenous cell receptor; the glucocorticoid receptor (GR). Emerging evidence, however, suggests that the mechanisms of GR action are more complex than previously assumed, with many reports of pro-inflammatory actions of GCs via the GR. While chronic exposure …
-
Hypoxia-mediated human pulmonary arterial fibroblast proliferation is dependent on p38 mitogen-activated protein kinase activity.
… 2000). Despite the mutation being present in all cells, vascular wall remodelling is only seen in the pulmonary circulation with marked thickening of the intima and neointimal formation, muscularisation of small-generation resistance vessels and thickening of the adventitial layer together with …